Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

YAP regulates cell mechanics by controlling focal adhesion assembly

(2017) Giorgia Nardone et al.   Nature Communications

Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

(2017) Qin Bian et al.   Bone Research

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration

(2017) Stephen M. Richardson et al.   Scientific Reports

MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

(2016) Tackhoon Kim et al.   EMBO JOURNAL

Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics

(2016) Sindhu Row et al.   JOURNAL OF CELL SCIENCE

SRF Co-factors Control the Balance between Cell Proliferation and Contractility

(2016) Francesco Gualdrini et al.   MOLECULAR CELL

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions

(2016) Priscilla Y Hwang et al.   Scientific Reports

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting

(2015) Makarand V. Risbud et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells

(2014) Nobuyuki Fujita et al.   FASEB JOURNAL

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

The Role Of Extracellular Matrix Elasticity and Composition In Regulating the Nucleus Pulposus Cell Phenotype in the Intervertebral Disc: A Narrative Review

(2014) Priscilla Y. Hwang et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Wnt Signaling Activates Shh Signaling in Early Postnatal Intervertebral Discs, and Re-Activates Shh Signaling in Old Discs in the Mouse

(2014) Tamara Winkler et al.   PLoS One

Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration

(2013) Aubrey T. Francisco et al.   Acta Biomaterialia

Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration

(2013) Aubrey T. Francisco et al.   BIOMATERIALS

The Hippo Effector Yorkie Controls Normal Tissue Growth by Antagonizing Scalloped-Mediated Default Repression

(2013) Laura M. Koontz et al.   DEVELOPMENTAL CELL

The State of US Health, 1990-2010

(2013) Christopher J. L. Murray   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis

(2013) Kathryn Ellis et al.   JOURNAL OF CELL BIOLOGY

Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc

(2013) D. T. Bridgen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

(2013) N. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis of intervertebral disc degeneration

(2013) Christopher K. Kepler et al.   Spine Journal

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Transcription factor regulation by mechanical stress

(2012) Melissa G. Mendez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins

(2012) Laura Leitner et al.   JOURNAL OF CELL SCIENCE

Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc

(2012) Liufang Jing et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular Matrix Ligand and Stiffness Modulate Immature Nucleus Pulposus Cell-Cell Interactions

(2011) Christopher L. Gilchrist et al.   PLoS One

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

(2011) K.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Mechanics: Dissecting the Physical Responses of Cells to Force

(2009) Brenton D. Hoffman et al.   Annual Review of Biomedical Engineering

Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs

(2009) Christine Lyn Le Maitre et al.   ARTHRITIS AND RHEUMATISM

Expression of Laminin Isoforms, Receptors, and Binding Proteins Unique to Nucleus Pulposus Cells of Immature Intervertebral Disc

(2009) Jun Chen et al.   CONNECTIVE TISSUE RESEARCH

Expression and Role of Connective Tissue Growth Factor in Painful Disc Fibrosis and Degeneration

(2009) Baogan Peng et al.   SPINE