LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures

Robust and Comprehensive Targeted Metabolomics Method for Quantification of 50 Different Primary, Secondary, and Sulfated Bile Acids in Multiple Biological Species (Human, Monkey, Rabbit, Dog, and Rat) and Matrices (Plasma and Urine) Using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Analysis

(2021) Dewakar Sangaraju et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position

(2020) Joe Carver et al.   BIOTECHNOLOGY PROGRESS

Regulation of Metabolic Homeostasis in Cell Culture Bioprocesses

(2020) Conor M. O'Brien et al.   TRENDS IN BIOTECHNOLOGY

Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Based Bioprocesses

(2020) Nicholas Alden et al.   Metabolites

A rapid derivatization based LC–MS/MS method for quantitation of short chain fatty acids in human plasma and urine

(2019) Allan Jaochico et al.   Bioanalysis

Metabolic engineering of Chinese hamster ovary cells towards reduced biosynthesis and accumulation of novel growth inhibitors in fed-batch cultures

(2019) Bhanu Chandra Mulukutla et al.   METABOLIC ENGINEERING

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

High resolution full scan liquid chromatography mass spectrometry comprehensive screening in sports antidoping urine analysis

(2018) Wadha Abushareeda et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

Biopharmaceutical benchmarks 2018

(2018) Gary Walsh   NATURE BIOTECHNOLOGY

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics

(2015) Tomas Cajka et al.   ANALYTICAL CHEMISTRY

Derivatization of the tricarboxylic acid intermediates with O-benzylhydroxylamine for liquid chromatography–tandem mass spectrometry detection

(2014) Bo Tan et al.   ANALYTICAL BIOCHEMISTRY

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

(2013) Nuno Carinhas et al.   BIOTECHNOLOGY AND BIOENGINEERING

An 'omics approach towards CHO cell engineering

(2013) Payel Datta et al.   BIOTECHNOLOGY AND BIOENGINEERING

The emerging CHO systems biology era: harnessing the ‘omics revolution for biotechnology

(2013) Helene Faustrup Kildegaard et al.   CURRENT OPINION IN BIOTECHNOLOGY

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

(2012) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modern analytical techniques in metabolomics analysis

(2011) Aihua Zhang et al.   ANALYST

Mammalian cell protein expression for biopharmaceutical production

(2011) Jianwei Zhu   BIOTECHNOLOGY ADVANCES

Chinese hamster genome database: An online resource for the CHO community at www.CHOgenome.org

(2011) Stephanie Hammond et al.   BIOTECHNOLOGY AND BIOENGINEERING

LC-MS-based metabolomics

(2011) Bin Zhou et al.   Molecular BioSystems

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

High-Throughput and Multiplexed LC/MS/MRM Method for Targeted Metabolomics

(2010) Ru Wei et al.   ANALYTICAL CHEMISTRY

Engineering mammalian cells in bioprocessing – current achievements and future perspectives

(2010) Yiping Lim et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells

(2010) Takeshi Omasa et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media

(2010) William P.K. Chong et al.   JOURNAL OF BIOTECHNOLOGY

Dynamic model of CHO cell metabolism

(2010) Ryan P. Nolan et al.   METABOLIC ENGINEERING