Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Maximizing antibody production in a targeted integration host by optimization of subunit gene dosage and position
Authors
Keywords
-
Journal
BIOTECHNOLOGY PROGRESS
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-01-22
DOI
10.1002/btpr.2967
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review
- (2018) Jean-Marc Bielser et al. BIOTECHNOLOGY ADVANCES
- Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis
- (2018) Sofie A. O'Brien et al. Biotechnology Journal
- A multi-landing pad DNA integration platform for mammalian cell engineering
- (2018) Leonid Gaidukov et al. NUCLEIC ACIDS RESEARCH
- Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis
- (2018) Sofie A. O'Brien et al. Biotechnology Journal
- Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells
- (2016) Michael Dillon et al. mAbs
- A method for specifically targeting two independent genomic integration sites for co-expression of genes in CHO cells
- (2016) Bahar Baser et al. METHODS
- Recombinase-mediated cassette exchange (RMCE) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line
- (2015) Lin Zhang et al. BIOTECHNOLOGY PROGRESS
- Engineering selection stringency on expression vector for the production of recombinant human alpha1-antitrypsin using Chinese Hamster ovary cells
- (2015) Christine Lin Chin et al. BMC BIOTECHNOLOGY
- Efficient folding/assembly in Chinese hamster ovary cells is critical for high quality (low aggregate content) of secreted trastuzumab as well as for high production: Stepwise multivariate regression analyses
- (2014) Yoichi Ishii et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies
- (2013) Yongping Crawford et al. BIOTECHNOLOGY PROGRESS
- Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality
- (2013) Prachi Bhoskar et al. BIOTECHNOLOGY PROGRESS
- Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability
- (2013) Steven C.L. Ho et al. JOURNAL OF BIOTECHNOLOGY
- Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system
- (2011) Yoshinori Kawabe et al. CYTOTECHNOLOGY
- Cell line-specific control of recombinant monoclonal antibody production by CHO cells
- (2010) Peter M. O'Callaghan et al. BIOTECHNOLOGY AND BIOENGINEERING
- Multiplexing RMCE: Versatile Extensions of the Flp-Recombinase-Mediated Cassette-Exchange Technology
- (2010) Soeren Turan et al. JOURNAL OF MOLECULAR BIOLOGY
- Utilization of Site-Specific Recombination for Generating Therapeutic Protein Producing Cell Lines
- (2010) Margie Campbell et al. MOLECULAR BIOTECHNOLOGY
- An accumulative site-specific gene integration system using cre recombinase-mediated cassette exchange
- (2009) Yujiro Kameyama et al. BIOTECHNOLOGY AND BIOENGINEERING
- Recombinant protein expression by targeting pre-selected chromosomal loci
- (2009) Kristina Nehlsen et al. BMC BIOTECHNOLOGY
- How antibodies fold
- (2009) Matthias J. Feige et al. TRENDS IN BIOCHEMICAL SCIENCES
- A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
- (2008) Janet Chusainow et al. BIOTECHNOLOGY AND BIOENGINEERING
- A clone screening method using mRNA levels to determine specific productivity and product quality for monoclonal antibodies
- (2008) Christina J. Lee et al. BIOTECHNOLOGY AND BIOENGINEERING
- On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells
- (2005) Stefan Schlatter et al. BIOTECHNOLOGY PROGRESS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now