Engineering mammalian cells in bioprocessing – current achievements and future perspectives

Expression of BHRF1 improves survival of murine hybridoma cultures in batch and continuous modes

(2009) Sandra Juanola et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

(2009) Haimanti Dorai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of Bcl-xLoverexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

(2009) Yeon-Gu Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

(2009) Brian S. Majors et al.   BIOTECHNOLOGY PROGRESS

Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells

(2009) Sebastian C. Y. Ku et al.   BIOTECHNOLOGY PROGRESS

Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33°C and 37°C

(2009) Yeon-Gu Kim et al.   BIOTECHNOLOGY PROGRESS

Identification and expression analysis of miRNAs during batch culture of HEK-293 cells

(2009) Thong-Chuan Koh et al.   JOURNAL OF BIOTECHNOLOGY

Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production

(2009) Yih Yean Lee et al.   JOURNAL OF BIOTECHNOLOGY

Increasing the sialylation of therapeutic glycoproteins: The potential of the sialic acid biosynthetic pathway

(2009) Kaya Bork et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells

(2008) Yeon Tae Jeong et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

(2008) Ren-Wang Peng et al.   BIOTECHNOLOGY AND BIOENGINEERING

Feast or famine: autophagy control and engineering in eukaryotic cell culture

(2008) Matthew P Zustiak et al.   CURRENT OPINION IN BIOTECHNOLOGY

An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

(2008) E BECKER et al.   JOURNAL OF BIOTECHNOLOGY

Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells

(2008) Sun Ok Hwang et al.   JOURNAL OF BIOTECHNOLOGY

Transcriptional Profiling of Gene Expression Changes in a PACE-Transfected CHO DUKX Cell Line Secreting High Levels of rhBMP-2

(2008) Padraig Doolan et al.   MOLECULAR BIOTECHNOLOGY

Production of Recombinant Human Factor VIII in Different Cell Lines and the Effect of Human XBP1 Co-Expression

(2008) Mariana Campos-da-Paz et al.   MOLECULAR BIOTECHNOLOGY

The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system

(2008) Helena L.A. Vieira et al.   PROTEIN EXPRESSION AND PURIFICATION

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

MicroRNAs as targets for engineering of CHO cell factories

(2008) Dethardt Müller et al.   TRENDS IN BIOTECHNOLOGY

Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression

(2007) Tomoshi Ohya et al.   BIOTECHNOLOGY AND BIOENGINEERING

Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture

(2007) Sun Ok Hwang et al.   BIOTECHNOLOGY AND BIOENGINEERING

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Cell Proliferation and Apoptosis in CHO-K1 Cells by the Coexpression of c-Myc and Bcl-2

(2005) Vasiliki Ifandi et al.   BIOTECHNOLOGY PROGRESS

Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line

(2005) Nicole Borth et al.   BIOTECHNOLOGY PROGRESS