Induction of microRNA hsa-let-7d-5p, and repression of HMGA2, contribute protection against lipid accumulation in macrophage ‘foam’ cells

Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation

(2020) Camila Yattah et al.   NEUROCHEMICAL RESEARCH

Analysis of Let-7 Family miRNA in Plasma as Potential Predictive Biomarkers of Diagnosis for Papillary Thyroid Cancer

(2020) Ewelina Perdas et al.   Diagnostics

Evaluation of an HMGA2 variant for pleiotropic effects on height and metabolic traits in ponies

(2019) Elaine M. Norton et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

(2019) Li Zhang et al.   Cell Death & Disease

MicroRNA Let-7d-3p Contributes to Cardiac Protection via Targeting HMGA2

(2019) Lee Wong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lin28a expression protects against streptozotocin‐induced β‐cell destruction and prevents diabetes in mice

(2019) Yonghun Sung et al.   CELL BIOCHEMISTRY AND FUNCTION

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

(2019) Jiangbing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL‐treated human vascular smooth muscle cells

(2019) Huifeng Pi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state

(2019) Sapir Hadadi-Bechor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques

(2019) Panagiotis Fotakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo

(2019) Meirav Segal et al.   Molecular Therapy-Nucleic Acids

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

(2018) Robin N Beaumont et al.   HUMAN MOLECULAR GENETICS

MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways

(2018) Osamu Baba et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-150 suppresses triple-negative breast cancer metastasis through targeting HMGA2

(2018) Wentao Tang et al.   OncoTargets and Therapy

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

(2018) Cynthia L. Hsu et al.   Nature Communications

Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

(2018) Luca Parisi et al.   Journal of Immunology Research

Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism

(2018) Keren E. Shapira et al.   MOLECULAR BIOLOGY OF THE CELL

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Downregulated microRNA-224 aggravates vulnerable atherosclerotic plaques and vascular remodeling in acute coronary syndrome through activation of the TGF-β/Smad pathway

(2018) Hai-Ming Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Liver X receptors link lipid metabolism and inflammation

(2017) Ira G. Schulman   FEBS LETTERS

Treatment of cardiovascular pathology with epigenetically active agents: Focus on natural and synthetic inhibitors of DNA methylation and histone deacetylation

(2017) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

(2017) Mercy R. PrabhuDas et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of foam cell formation in atherosclerosis

(2017) Dimitry A. Chistiakov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury

(2017) Huimin Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression of hsa-let-7b-5p, hsa-let-7f-5p, and hsa-miR-222-3p and their putative targets HMGA2 and CDKN1B in typical and atypical carcinoid tumors of the lung

(2017) Pietro Di Fazio et al.   TUMOR BIOLOGY

Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL

(2017) Xue Wang et al.   Oncotarget

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

(2017) Rodney Elwood Infante et al.   eLife

MicroRNAs in lipid metabolism and atherosclerosis

(2016) Hector Giral et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

microRNA-150 inhibits the formation of macrophage foam cells through targeting adiponectin receptor 2

(2016) Jing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ

(2016) Yang Xi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA methylation in cystathionine-γ-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice

(2016) Hua-Ping Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular cholesterol transport proteins: roles in health and disease

(2016) U. Soffientini et al.   CLINICAL SCIENCE

Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells

(2016) Zhan Shi et al.   JOURNAL OF BIOSCIENCES

SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation

(2016) Nathan L. Price et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction

(2016) K Shan et al.   Cell Death & Disease

Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva

(2016) Antonio Agostini et al.   Oncotarget

Liver X receptors at the intersection of lipid metabolism and atherogenesis

(2015) Stephen D. Lee et al.   ATHEROSCLEROSIS

miRNA let-7 expression is regulated by glucose and TNF-  by a remote upstream promoter

(2015) M. Katayama et al.   BIOCHEMICAL JOURNAL

The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis

(2015) Siroon Bekkering et al.   CLINICAL THERAPEUTICS

Nonivamide Enhances miRNA let-7d Expression and Decreases Adipogenesis PPARγ Expression in 3T3-L1 Cells

(2015) Barbara Rohm et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammatory cytokines induce specific time- and concentration-dependent MicroRNA release by chondrocytes, synoviocytes, and meniscus cells

(2015) Amaris A. Genemaras et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Macrophage Differentiation from Monocytes Is Influenced by the Lipid Oxidation Degree of Low Density Lipoprotein

(2015) Jin-Won Seo et al.   MEDIATORS OF INFLAMMATION

The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells

(2015) Shaneabbas Raza et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Association Analysis of Genetic Variants with Type 2 Diabetes in a Mongolian Population in China

(2015) Haihua Bai et al.   Journal of Diabetes Research

Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype

(2014) Janice M. W. Taylor et al.   CLINICAL SCIENCE

let-7 Enhances Osteogenesis and Bone Formation While Repressing Adipogenesis of Human Stromal/Mesenchymal Stem Cells by Regulating HMGA2

(2014) Jianfeng Wei et al.   STEM CELLS AND DEVELOPMENT

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

MicroRNA-33a Mediates the Regulation of High Mobility Group AT-Hook 2 Gene (HMGA2) by Thyroid Transcription Factor 1 (TTF-1/NKX2–1)

(2013) Shawn J. Rice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidized LDL Induces Alternative Macrophage Phenotype through Activation of CD36 and PAFR

(2013) Francisco J. Rios et al.   MEDIATORS OF INFLAMMATION

Does TP53 mutation promote ovarian cancer metastasis to omentum by regulating lipid metabolism?

(2013) Jing Hu et al.   MEDICAL HYPOTHESES

Evidence That an HMGA1 Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Population

(2013) Clive R. Pullinger et al.   Metabolic Syndrome and Related Disorders

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

(2013) Dominic De Nardo et al.   NATURE IMMUNOLOGY

Permanent activation of HMGA2 in lipomas mimics its temporal physiological activation linked to the gain of adipose tissue

(2013) Helge W. Thies et al.   Obesity

TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: A dominant role for Smad-2

(2012) Daryn R. Michael et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA let-7a Inhibits the Proliferation and Invasion of Nonsmall Cell Lung Cancer Cell Line 95D by Regulating K-Ras and HMGA2 Gene Expression

(2012) Yan-ying Wang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines

(2012) Pietro Di Fazio et al.   EXPERIMENTAL CELL RESEARCH

Alteration of lipids and the transcription of lipid-related genes in myelodysplastic syndromes via a TP53-related pathway

(2012) Martin H. Ellis et al.   EXPERIMENTAL HEMATOLOGY

Altered MicroRNA Expression Profile in Human Pituitary GH Adenomas: Down-Regulation of miRNA Targeting HMGA1, HMGA2, and E2F1

(2012) Daniela D'Angelo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Atorvastatin suppresses inflammatory response induced by oxLDL through inhibition of ERK phosphorylation, IκBα degradation, and COX-2 expression in murine macrophages

(2011) Qin Shao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Native Low-Density Lipoprotein Uptake by Macrophage Colony-Stimulating Factor–Differentiated Human Macrophages Is Mediated by Macropinocytosis and Micropinocytosis

(2010) Joshua J. Anzinger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized LDL enhances pro-inflammatory responses of alternatively activated M2 macrophages: A crucial role for Krüppel-like factor 2

(2010) L.J.H. van Tits et al.   ATHEROSCLEROSIS

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

Mechanisms of LDL oxidation

(2010) Hiroshi Yoshida et al.   CLINICA CHIMICA ACTA

7-Ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages

(2010) Zhenyu Huang et al.   LIFE SCIENCES

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses

(2009) Laurent Yvan-Charvet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation

(2009) Alexandra Kadl et al.   ARTHRITIS AND RHEUMATISM

Ink4a/Arf Regulation by let-7b and Hmga2: A Genetic Pathway Governing Stem Cell Aging

(2008) Alexandros Tzatsos et al.   Cell Stem Cell

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein

(2008) Yun Soo Bae et al.   CIRCULATION RESEARCH

Cholesteryl Ester Hydroperoxides Are Biologically Active Components of Minimally Oxidized Low Density Lipoprotein

(2008) Richard Harkewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY