Article
Medicine, Research & Experimental
Fatemeh Yazarlou, Sepideh Kadkhoda, Soudeh Ghafouri-Fard
Summary: Let-7 is a family of miRNA that plays a crucial role in various hematological malignancies by influencing the expression of oncogenic pathways. The expression of these miRNAs varies between different hematological malignancies, highlighting their importance in disease treatment and prognosis. This review summarizes the data on biogenesis, genomic locations, targets, and regulatory networks of Let-7 in the context of hematological malignancies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Jiahui Song, Haining Lv, Beibei Liu, Mingjun Hao, Hugh S. Taylor, Xuchen Zhang, Da Li, Yingqun Huang
Summary: The study reveals the important role of let-7 in liver fibrosis progression. It inhibits the production of TGF-I31 and expression of FAS, thereby reducing hepatocyte apoptosis and liver fibrosis. The findings highlight the potential use of let-7 and its derivatives as therapeutic agents for liver fibrosis.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Maximillian S. Westphal, Eunjee Lee, Eric E. Schadt, Giselle S. Sholler, Jun Zhu
Summary: This study categorized medulloblastoma into molecular subgroups and found different survival rates among them. By analyzing the expression of molecular markers MYCN and let-7, one subgroup was further divided and it was found that high MYCN expression and high let-7 activity are associated with worse overall survival. These findings provide critical information for personalized treatment options for medulloblastoma.
Review
Biochemistry & Molecular Biology
Ya Wang, Juanjuan Zhao, Shipeng Chen, Dongmei Li, Jing Yang, Xu Zhao, Ming Qin, Mengmeng Guo, Chao Chen, Zhixu He, Ya Zhou, Lin Xu
Summary: Abnormal regulation and expression of microRNA, especially let-7, are closely related to the aging process and aging-related diseases. Let-7 plays a crucial role in development and is elevated in aging tissues, participating in multiple pathways that regulate aging. Recent studies also suggest that let-7 may be involved in aging by regulating immune function.
Article
Entomology
Yu Fu, Yi Wang, Qunxia Huang, Chenyue Zhao, Xinmei Li, Yunchao Kan, Dandan Li
Summary: This study found that lncRNA lncR17454 in silkworm is involved in the metamorphosis process through the let-7 miRNA cluster and the ecdysone signaling pathway, providing new clues for lepidopteran pest control.
JOURNAL OF INSECT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chun Li, Bohyung Yoon, Giovanni Stefani, Frank J. Slack
Summary: This study reveals a novel role for lipid kinase PPK-1/PIP5K1A in regulating miRNA levels. PPK-1/PIP5K1A is able to control the levels of let-7 miRNA in C. elegans and human cells. It interacts with nuclear export protein XPO5 to block the binding of XPO5 to pre-let-7 miRNA, thus regulating the levels of mature miRNA.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Joshua Miguel C. Danac, Reynaldo L. Garcia
Summary: Circular RNAs play important roles in disease processes. Studies have shown that circPVT1 is involved in cancer progression, and its knockdown can reduce the survival and migration abilities of cancer cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Seong Heon Kim, Bi-Oh Park, Kidae Kim, Byoung Chul Park, Sung Goo Park, Jeong-Hoon Kim, Sunhong Kim
Summary: This study revealed that Sjogren Syndrome antigen B (SSB) protein interacts with LIN28A and LIN28B in the nucleus, regulating the LIN28-let-7 axis and impacting developmental timing control.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Veterinary Sciences
Alexandra Kehl, Mario Valkai, Anna-Lena van de Weyer, Maria Brockmann, Katja Steiger, Benjamin Schusser, Heike Aupperle-Lellbach
Summary: Carcinomas and lymphomas are common intestinal tumors in dogs. Non-invasive biomarkers like microRNAs could help distinguish them from intestinal inflammation. This study measured the expression of specific microRNAs in different types of intestinal tumors and tissues, and observed significant changes in microRNA expression patterns. However, further research is needed to understand the role of different microRNAs in various types of tissue and cancer.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Guanguan Qiu, Jiajie Fan, Guoping Zheng, Jiangping He, Fangping Lin, Menghua Ge, Lanfang Huang, Jiangmei Wang, Jie Xia, Ruoqiong Huang, Qiang Shu, Jianguo Xu
Summary: This study reveals the potential role of plasma EV-miRNAs in the pathogenesis of sepsis and demonstrates the diagnostic value of combining miR-483-3p and let-7d-3p as biomarkers for early sepsis diagnosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Jose Pedro Sequeira, Vera Constancio, Sofia Salta, Joao Lobo, Daniela Barros-Silva, Carina Carvalho-Maia, Jessica Rodrigues, Isaac Braga, Rui Henrique, Carmen Jeronimo
Summary: Early detection of renal cell carcinoma (RCC) is crucial, and using circulating microRNAs for early, minimally invasive detection and diagnosis is feasible.
Article
Oncology
Hanmin Wang, Evgeny Chirshev, Nozomi Hojo, Tise Suzuki, Antonella Bertucci, Michael Pierce, Christopher Perry, Ruining Wang, Jeffrey Zink, Carlotta A. Glackin, Yevgeniya J. Ioffe, Juli J. Unternaehrer
Summary: The study investigated the mechanism of epithelial-mesenchymal transition (EMT)-induced stemness in cancer cells, revealing the crucial role of the SNAI1/let-7 axis in stemness pathways. The results provide a rationale for future research on targeting this axis for cancer stem cell-specific therapies.
Article
Biochemistry & Molecular Biology
Gabriela Diaz-Pina, Karla Rubio, Rosa M. Ordonez-Razo, Guillermo Barreto, Eduardo Montes, Carina Becerril, Alfonso Salgado, Hector Cabrera-Fuentes, Arnoldo Aquino-Galvez, Angeles Carlos-Reyes, Victor Ruiz
Summary: The study suggests that ADAR1 isoforms and Let-7d may have a synergistic role in the development of IPF, indicating that regulating both molecules could be a potential therapeutic approach for IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Abeer Al-Abdallah, Iman Jahanbani, Rola H. Ali, Nabeel Al-Brahim, Jeena Prasanth, Bashayer Al-Shammary, Maie Al-Bader
Summary: This study aimed to investigate the expression, function and spatial dynamics of epidermal growth factor receptor (EGFR) in papillary thyroid cancer (PTC) and non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in relation to specific miRNA alterations. The results showed that in PTC, EGFR mRNA level is decreased due to upregulation of miR-146b-5p, while in NIFTP, EGFR transcription is increased associated with downregulation of miR-7-5p. Further research is needed to understand the intracellular trafficking defects responsible for the specific EGFR dynamics in PTC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Liqun Wang, Tingli Liu, Guoliang Chen, Yanping Li, Shaohua Zhang, Li Mao, Panhong Liang, Majid Fasihi Harandi, Taoshan Li, Xuenong Luo
Summary: The study reveals that miR-let-7-5p released by Taenia pisiformis cysticercus plays a critical role in activating M2 macrophages, inducing M2 macrophage polarization by targeting C/EBP delta.
Article
Multidisciplinary Sciences
Konrad Walczak, Robert Stawski, Ewelina Perdas, Olga Brzezinska, Piotr Kosielski, Szymon Galczynski, Tomasz Budlewski, Gianluca Padula, Dariusz Nowak
Summary: The study compared the increase in cf DNA after exercise in men with T1DM and healthy controls, finding that there was no significant difference in exercise-induced increment in cf n-DNA between the two groups. However, in the control group, this variable correlated with run distance, Delta neutrophils, Delta creatinine, and Delta creatine kinase.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Robert Stawski, Konrad Walczak, Ewelina Perdas, Anna Prymont-Przyminska, Anna Zwolinska, Piotr Kosielski, Tomasz Budlewski, Gianluca Padula, Hanna Jerczynska, Dariusz Nowak
Summary: Histones and PAD4 levels increase in response to strenuous exercise, but there is no significant correlation between citrullinated histone and aggregation of cell-free nDNA. Positive correlations have been observed between cf nDNA with aggregation and PAD4, lactate with aggregation, and lactate with citrullinated histone.
Review
Biology
Robert Stawski, Emilia Stec-Martyna, Adam Chmielecki, Dariusz Nowak, Ewelina Perdas
Summary: Cell-free DNA is commonly found in healthy individuals but increases after physical activity, in patients with trauma, sepsis, and cancer. Current trends in cfDNA applications from clinical trials include oncology, prenatal diagnostics, and organ transplantation. The diagnostic value and accuracy of cfDNA remain controversial, requiring further evaluation before becoming a standard in clinical practice.
Meeting Abstract
Hematology
Agnieszka Wierzbowska, Agnieszka Pluta, Anna Czyz, Marta Antonina Libura, Sebastian Giebel, Magdalena Czemerska, Piotr Stelmach, Michal Soin, Anna Kopinska, Krzysztof Wozniczka, Grzegorz Helbig, Marta Sobas, Tomasz Wrobel, Andrzej Szczepaniak, Lidia Gil, Karol Wojcik, Malgorzata Razny, Magdalena Dutka, Maria Bieniaszewska, Janusz Halka, Tomasz Gromek, Marek Hus, Elzbieta Patkowska, Jolanta Wozniak, Edyta Cichocka, Agata Obara, Agnieszka Kopacz, Katarzyna Dulik, Jerzy Holowiecki, Damian Mikulski, Ewelina Perdas, Wojciech Fendler, Nicole M. Cruz, Nuria Mencia-Trinchant, Pinkal Desai, Sangmin Lee, Michael B. Samuel, Justin D. Kaner, Ellen Ritchie, Monica L. Guzman, Gail J. Roboz
Meeting Abstract
Hematology
Damian Mikulski, Izabela Drozdz, Ewelina Perdas, Konrad Stawiski, Mateusz Nowicki, Malgorzata Misiewicz, Piotr Strzalka, Agnieszka Wierzbowska, Wojciech Fendler
Review
Virology
Robert Stawski, Dariusz Nowak, Ewelina Perdas
Summary: WHO has declared COVID-19 as a global public health emergency. The elderly, pregnant women, and individuals with associated co-morbidities are the most susceptible population groups to infection. Cell-free DNA appears to be a valuable marker for COVID-19 risk assessment, as well as for measuring the complications and underlying health risk factors associated with the disease.
Article
Medicine, General & Internal
Damian Mikulski, Pawel Robak, Ewelina Perdas, Edyta Weglowska, Aleksandra Losiewicz, Izabela Drozdz, Dariusz Jarych, Malgorzata Misiewicz, Janusz Szemraj, Wojciech Fendler, Tadeusz Robak
Summary: Multiple myeloma is a disease characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. Cytokines, such as IL-13 and IL-4, play an important role in the growth and survival of multiple myeloma. This study found that pretreatment levels of IL-13 and IL-4 are predictors of better progression-free survival and overall survival, while IL-1Ra levels negatively impact overall survival in patients treated with bortezomib-based chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Adam Chmielecki, Krzysztof Bortnik, Szymon Galczynski, Gianluca Padula, Hanna Jerczynska, Robert Stawski, Dariusz Nowak
Summary: Strenuous exercise can temporarily increase spontaneous oxidant production by circulating phagocytes, while decreasing their response to fMLP. This suggests that exercise can activate mechanisms leading to increased antioxidant activity in regularly training individuals.
Article
Cardiac & Cardiovascular Systems
Aleksandra Stasiak, Piotr Kedziora, Beata Kierzkowska, Katarzyna Niewiadomska-Jarosik, Ewelina Perdas, Elzbieta Smolewska
Summary: Pediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS) is a serious complication in pediatric patients. This study retrospectively analyzed demographic data, clinical course, laboratory tests, and cardiovascular system assessment of 51 patients with PIMS-TS. Results showed that changes in the cardiovascular system in PIMS-TS are diverse, and most patients require close cardiac supervision and long-term follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiolek
Summary: This study assessed the effects of fatty acid amide hydrolase inhibitor URB597 in an animal model of orofacial pain caused by tooth pulp stimulation. The results showed that URB597, by inhibiting the metabolism of endocannabinoids and reducing gene expression levels, effectively prevented orofacial pain, providing a promising therapeutic target for its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ewelina Perdas, Karolina Gadzalska, Ihor Hrytsiuk, Maciej Borowiec, Wojciech Fendler, Wojciech Mlynarski
Summary: Neonatal diabetes mellitus with congenital hypothyroidism (NDH) syndrome is a rare disease caused by mutations in the GLIS3 gene. This study reports a new case of NDH syndrome and identifies two novel mutations in the GLIS3 gene. The findings provide important insights into the clinical phenotype, treatment approaches, and outcome of infants with GLIS3 mutations.
PEDIATRIC DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Aneta Otocka-Kmiecik, Monika Orlowska-Majdak, Robert Stawski, Urszula Szkudlarek, Gianluca Padula, Szymon Galczynski, Dariusz Nowak
Summary: Exercise can increase plasma antioxidant capacity by stimulating antioxidant enzymes. This study measured the effect of acute exercise on ARE activity of the PON1 enzyme and found that ARE activity remained stable during exercise but decreased after exercise when standardized for PON1 concentration. The ratio of ARE/PON1c returned to baseline levels during rest after each exercise session. Individuals with lower pre-exercise ARE activity may experience a higher inflammatory response to vigorous exercise.
Article
Biochemistry & Molecular Biology
Marek Zubrzycki, Maria Zubrzycka, Grzegorz Wysiadecki, Janusz Szemraj, Hanna Jerczynska, Mariusz Stasiolek
Summary: The endocannabinoid system plays a role in pain processing, and this study aimed to investigate its effects in the orofacial area. The results showed that endocannabinoid AEA can modulate neural structures and may have different regulatory mechanisms than 2-AG in orofacial pain.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
