Mechanisms of foam cell formation in atherosclerosis

Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation

(2016) Rafaela F. da Silva et al.   ATHEROSCLEROSIS

microRNAs in lipoprotein metabolism and cardiometabolic disorders

(2016) Noemi Rotllan et al.   ATHEROSCLEROSIS

HDL mimetic CER-001 targets atherosclerotic plaques in patients

(2016) Kang He Zheng et al.   ATHEROSCLEROSIS

Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells

(2016) Emma M. Corr et al.   ATHEROSCLEROSIS

microRNA-150 inhibits the formation of macrophage foam cells through targeting adiponectin receptor 2

(2016) Jing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiR-486 regulates cholesterol efflux by targeting HAT1

(2016) Dan Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-134 actives lipoprotein lipase-mediated lipid accumulation and inflammatory response by targeting angiopoietin-like 4 in THP-1 macrophages

(2016) Gang Lan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway

(2016) Duo Gong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miRNA-133a attenuates lipid accumulation via TR4-CD36 pathway in macrophages

(2016) Xiao-Ping Peng et al.   BIOCHIMIE

So Much Cholesterol

(2016) Joshua A. Dubland et al.   CURRENT OPINION IN LIPIDOLOGY

Links between atherosclerotic and periodontal disease

(2016) Dimitry A. Chistiakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

High-Density Lipoprotein Mimetics: a Therapeutic Tool for Atherosclerotic Diseases

(2016) Masahiro Ikenaga et al.   Journal of Atherosclerosis and Thrombosis

Potential Anti-Atherosclerotic Properties of Astaxanthin

(2016) Yoshimi Kishimoto et al.   Marine Drugs

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway

(2016) Hai-Jian Sun et al.   Scientific Reports

The effect of an apolipoprotein A-I–containing high-density lipoprotein–mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia

(2015) G. Kees Hovingh et al.   AMERICAN HEART JOURNAL

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression via LOX-1/Ca2+/PKC-β signal in human umbilical vein endothelial cells

(2015) Yuan-Bin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Class A1 scavenger receptors in cardiovascular diseases

(2015) Jingjing Ben et al.   BRITISH JOURNAL OF PHARMACOLOGY

Scavenger receptors and non-coding RNAs: relevance in atherogenesis

(2015) Yao Dai et al.   CARDIOVASCULAR RESEARCH

Cross-talk between LOX-1 and PCSK9 in vascular tissues

(2015) Zufeng Ding et al.   CARDIOVASCULAR RESEARCH

High-Density Lipoprotein-Targeted Therapy and Apolipoprotein A-I Mimetic Peptides

(2015) Yoshinari Uehara et al.   CIRCULATION JOURNAL

Endothelial and smooth muscle cell transformation in atherosclerosis

(2015) Ka Hou Lao et al.   CURRENT OPINION IN LIPIDOLOGY

Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL

(2015) Patrick M. Hutchins et al.   CURRENT OPINION IN LIPIDOLOGY

Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease

(2015) Elisa Araldi et al.   Current Vascular Pharmacology

MicroRNA-101 overexpression by IL-6 and TNF-α inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression

(2015) Nan Zhang et al.   EXPERIMENTAL CELL RESEARCH

Macrophage phenotypic plasticity in atherosclerosis: The associated features and the peculiarities of the expression of inflammatory genes

(2015) Dimitry A. Chistiakov et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

miR-223 Inhibits Lipid Deposition and Inflammation by Suppressing Toll-Like Receptor 4 Signaling in Macrophages

(2015) Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macrophage-mediated cholesterol handling in atherosclerosis

(2015) Dimitry A. Chistiakov et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glucagon-Like Receptor 1 Agonists and DPP-4 Inhibitors: Potential Therapies for the Treatment of Stroke

(2015) Vladimer Darsalia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

(2015) Ruud S. Kootte et al.   JOURNAL OF LIPID RESEARCH

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Endothelial Barrier and Its Abnormalities in Cardiovascular Disease

(2015) Dimitry A. Chistiakov et al.   Frontiers in Physiology

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation

(2015) Claudine Tardy et al.   PLoS One

Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation

(2015) Patrice N. Mimche et al.   PLoS One

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

(2014) Marta Yanina Pepino et al.   Annual Review of Nutrition

Coenzyme Q10 Promotes Macrophage Cholesterol Efflux by Regulation of the Activator Protein-1/miR-378/ATP-Binding Cassette Transporter G1–Signaling Pathway

(2014) Dongliang Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells

(2014) Guo-jun Zhao et al.   ATHEROSCLEROSIS

MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages

(2014) Min Zhang et al.   ATHEROSCLEROSIS

MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1

(2014) Yun-Cheng Lv et al.   ATHEROSCLEROSIS

Lipoprotein lipase: From gene to atherosclerosis

(2014) Yuan Li et al.   ATHEROSCLEROSIS

Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization

(2014) Dmitry Namgaladze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

(2014) Ping-Ping He et al.   BIOCHIMIE

Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis

(2014) Fu-Ju Tian et al.   CARDIOVASCULAR RESEARCH

Macrophage Phenotypes and Their Modulation in Atherosclerosis

(2014) Federica De Paoli et al.   CIRCULATION JOURNAL

Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial

(2014) J.-C. Tardif et al.   EUROPEAN HEART JOURNAL

Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages

(2014) Kent Sakai et al.   JOURNAL OF LIPID RESEARCH

miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease

(2014) Jun Feng et al.   Lipids in Health and Disease

An Agomir of miR-144-3p Accelerates Plaque Formation through Impairing Reverse Cholesterol Transport and Promoting Pro-Inflammatory Cytokine Production

(2014) Yan-Wei Hu et al.   PLoS One

MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation

(2013) J. Xu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice

(2013) Claudine Tardy et al.   ATHEROSCLEROSIS

Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage

(2013) Xian-Hui Wang et al.   CELLULAR SIGNALLING

Foam cells in atherosclerosis

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein α

(2013) Jing Ge et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CXCL5 limits macrophage foam cell formation in atherosclerosis

(2013) Anthony Rousselle et al.   JOURNAL OF CLINICAL INVESTIGATION

LOX-1, OxLDL, and Atherosclerosis

(2013) Angela Pirillo et al.   MEDIATORS OF INFLAMMATION

Preventive Effect of Dipeptidyl Peptidase-4 Inhibitor on Atherosclerosis Is Mainly Attributable to Incretin's Actions in Nondiabetic and Diabetic Apolipoprotein E-Null Mice

(2013) Michishige Terasaki et al.   PLoS One

Early steps in reverse cholesterol transport

(2013) Shobha Ghosh   Current Opinion in Endocrinology Diabetes and Obesity

PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway

(2012) Shi-Lin Tang et al.   ATHEROSCLEROSIS

Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages

(2012) Hee-jin Jun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Extra-virgin olive oil consumption improves the capacity of HDL to mediate cholesterol efflux and increases ABCA1 and ABCG1 expression in human macrophages

(2012) Olfa Helal et al.   BRITISH JOURNAL OF NUTRITION

Interleukin-18 and Interleukin-12 Together Downregulate ATP-Binding Cassette Transporter A1 Expression Through the Interleukin-18R/Nuclear Factor-^|^kappa;B Signaling Pathway in THP-1 Macrophage-Derived Foam Cells

(2012) Xiao-Hua Yu et al.   CIRCULATION JOURNAL

Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b

(2012) Dongliang Wang et al.   CIRCULATION RESEARCH

Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction

(2012) Misato Hashizume et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARγ and adenosine

(2012) Iryna Voloshyna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis

(2012) Dan Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL

(2012) Yong Yang et al.   JOURNAL OF LIPID RESEARCH

Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice

(2012) Xiao-Yan Dai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis

(2012) Jing-Feng Zhao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages

(2012) Sergio Granados-Principal et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin up-regulates expressions of peroxisome proliferator-activated receptor γ, liver X receptor α, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line

(2012) Seung-Min Lee et al.   NUTRITION RESEARCH

The Antibody Targeting the E314 Peptide of Human Kv1.3 Pore Region Serves as a Novel, Potent and Specific Channel Blocker

(2012) Xiao-Fang Yang et al.   PLoS One

CD36 Inhibitors Reduce Postprandial Hypertriglyceridemia and Protect against Diabetic Dyslipidemia and Atherosclerosis

(2012) Alain Geloen et al.   PLoS One

Highly Upregulated Expression of CD36 and MSR1 in Circulating Monocytes of Patients with Acute Coronary Syndromes

(2012) Michal Piechota et al.   PROTEIN JOURNAL

Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo

(2011) Masatsune Ogura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis

(2011) Illiana Meurs et al.   ATHEROSCLEROSIS

Oxidized LDL, LOX-1 and Atherosclerosis

(2011) Sona Mitra et al.   CARDIOVASCULAR DRUGS AND THERAPY

MicroRNAs in Cardiometabolic Disease

(2011) S. Hani Najafi-Shoushtari   Current Atherosclerosis Reports

Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice

(2011) M. Nagashima et al.   DIABETOLOGIA

Hydrogen sulfide inhibits macrophage-derived foam cell formation

(2011) Zhan-Zhi Zhao et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Role of Neutral Cholesterol Ester Hydrolysis in Macrophage Foam Cells

(2011) Motohiro Sekiya et al.   Journal of Atherosclerosis and Thrombosis

Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population

(2011) A. Handberg et al.   JOURNAL OF INTERNAL MEDICINE

Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages

(2011) Chai Siah Ku et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages

(2011) Ines Kämmerer et al.   Lipids in Health and Disease

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors

(2010) P. I. Makinen et al.   CARDIOVASCULAR RESEARCH

The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages

(2010) Masaki Igarashi et al.   CIRCULATION RESEARCH

Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages

(2010) Harumi Uto-Kondo et al.   CIRCULATION RESEARCH

Tanshinone IIA attenuates atherosclerosis in ApoE−/− mice through down-regulation of scavenger receptor expression

(2010) Fu-Tian Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Soluble CD36 (sCD36) Clusters with Markers of Insulin Resistance, and High sCD36 Is Associated with Increased Type 2 Diabetes Risk

(2010) A. Handberg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MARCO, a macrophage scavenger receptor highly expressed in rodents, mediates dalcetrapib-induced uptake of lipids by rat and mouse macrophages

(2010) Anne Perez et al.   TOXICOLOGY IN VITRO

Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages

(2009) Shigeki Hongo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ghrelin inhibits foam cell formation via simultaneously down-regulating the expression of acyl-coenzyme A:cholesterol acyltransferase 1 and up-regulating adenosine triphosphate-binding cassette transporter A1

(2009) Bei Cheng et al.   CARDIOVASCULAR PATHOLOGY

Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

(2009) Motohiro Sekiya et al.   Cell Metabolism

LOX-1

(2009) Sayoko Ogura et al.   CIRCULATION JOURNAL

Dietary Compound Quercitrin Dampens VEGF Induction and PPARγ Activation in Oxidized LDL-Exposed Murine Macrophages: Association with Scavenger Receptor CD36

(2009) Jung-Suk Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

(2009) David F. Schaeffer et al.   JOURNAL OF LIPID RESEARCH

Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence

(2009) Masaki Igarashi et al.   JOURNAL OF LIPID RESEARCH

Testing the inflammatory hypothesis of atherothrombosis: scientific rationale for the cardiovascular inflammation reduction trial (CIRT)

(2009) PAUL M. RIDKER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prominent Lectin-Like Oxidized Low Density Lipoprotein (LDL) Receptor-1 (LOX-1) Expression in Atherosclerotic Lesions Is Associated with Tissue Factor Expression and Apoptosis in Hypercholesterolemic Rabbits

(2008) Yuji Kuge et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

CD36 mRNA EXPRESSION IS INCREASED IN CD14+MONOCYTES OF PATIENTS WITH CORONARY HEART DISEASE

(2008) D Teupser et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages

(2008) Hiroaki Okazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance

(2008) Jose-Manuel Fernández-Real et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY