Circadian Control of Mitochondria in Reactive Oxygen Species Homeostasis

Mechanism of circadian regulation of the NRF2/ARE pathway in renal ischemia‑reperfusion

(2021) Qian Sun et al.   Experimental and Therapeutic Medicine

Two‐meal caloric restriction induces 12‐hour rhythms and improves glucose homeostasis

(2021) Nikkhil Velingkaar et al.   FASEB JOURNAL

Reduced caloric intake and periodic fasting independently contribute to metabolic effects of caloric restriction

(2020) Nikkhil Velingkaar et al.   AGING CELL

Circadian regulation of mitochondrial uncoupling and lifespan

(2020) Matt Ulgherait et al.   Nature Communications

BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

(2020) Ermin Li et al.   Protein & Cell

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

(2020) Bhavana Chhunchha et al.   Cells

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plant Glutathione Transferases and Light

(2019) Ágnes Gallé et al.   Frontiers in Plant Science

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

(2019) Ben J. Greenwell et al.   Cell Reports

Defining the Independence of the Liver Circadian Clock

(2019) Kevin B. Koronowski et al.   CELL

Heat shock induces the cellular antioxidant defenses peroxiredoxin, glutathione and glucose 6-phosphate dehydrogenase through Nrf2

(2019) Marceline Tchouagué et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks

(2019) Jian-Fei Pei et al.   NATURE CELL BIOLOGY

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

(2019) Kazunari Nohara et al.   Nature Communications

Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway

(2019) Guohua Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial uncoupling, ROS generation and cardioprotection

(2018) Susana Cadenas   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

(2018) Karen Schmitt et al.   Cell Metabolism

ROS and RNS signalling: adaptive redox switches through oxidative/nitrosative protein modifications

(2018) N. T. Moldogazieva et al.   FREE RADICAL RESEARCH

Circadian rhythms in mitochondrial respiration

(2018) Paul de Goede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo

(2018) Ryan S. Wible et al.   MOLECULAR PHARMACOLOGY

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

(2018) Ryan S Wible et al.   eLife

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

(2018) In-geun Ryoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diurnal changes in tomato glutathione transferase activity and expression

(2018) Ágnes Gallé et al.   ACTA BIOLOGICA HUNGARICA

Calorie restriction reprograms diurnal rhythms in protein translation to regulate metabolism

(2018) Kuldeep Makwana et al.   FASEB JOURNAL

Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

(2017) Amol Chaudhari et al.   MOLECULAR BIOLOGY OF THE CELL

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Cellular Timekeeping: It’s Redox o’Clock

(2017) Nikolay B. Milev et al.   Cold Spring Harbor Perspectives in Biology

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

(2017) Jingxin Liu et al.   Cell Death & Disease

Calorie restriction effects on circadian rhythms in gene expression are sex dependent

(2017) Artem A. Astafev et al.   Scientific Reports

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

(2017) Daniel Mauvoisin et al.   Cell Reports

Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay

(2016) Rosella Scrima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Pentose Phosphate Pathway Regulates the Circadian Clock

(2016) Guillaume Rey et al.   Cell Metabolism

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

(2016) Lisha Zhou et al.   EMBO REPORTS

GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats

(2016) Bo Hu et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression

(2016) Katarzyna Goljanek-Whysall et al.   MAMMALIAN GENOME

Gamma-Glutamylcysteine Ethyl Ester Protects against Cyclophosphamide-Induced Liver Injury and Hematologic Alterations via Upregulation of PPARγand Attenuation of Oxidative Stress, Inflammation, and Apoptosis

(2016) Sultan Alqahtani et al.   Oxidative Medicine and Cellular Longevity

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

(2016) Adi Neufeld-Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

(2016) Dirk van Moorsel et al.   Molecular Metabolism

The circadian clock gene period extends healthspan in aging Drosophila melanogaster

(2016) Natraj Krishnan et al.   Aging-US

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis

(2014) V. Pekovic-Vaughan et al.   GENES & DEVELOPMENT

The p66Shc Adaptor Protein Controls Oxidative Stress Response in Early Bovine Embryos

(2014) Dean H. Betts et al.   PLoS One

The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice

(2014) Akira Kohsaka et al.   PLoS One

Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues

(2014) Valerio Mori et al.   PLoS One

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Circadian aspects of energy metabolism and aging

(2013) Oren Froy   AGEING RESEARCH REVIEWS

Transcriptional Control of Antioxidant Defense by the Circadian Clock

(2013) Sonal A. Patel et al.   ANTIOXIDANTS & REDOX SIGNALING

Skin, Reactive Oxygen Species, and Circadian Clocks

(2013) Mary A. Ndiaye et al.   ANTIOXIDANTS & REDOX SIGNALING

New insights into the function and regulation of mitochondrial fission

(2013) Hidenori Otera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation

(2013) Kasturi Mitra   BIOESSAYS

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics

(2013) Marcel V Alavi et al.   Molecular Neurodegeneration

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

(2013) Zachary Gerhart-Hines et al.   NATURE

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals

(2013) Teruya Tamaru et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress

(2013) Y Cheng et al.   Cell Death & Disease

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Role of the circadian clock gene Per2 in adaptation to cold temperature

(2013) Sylvie Chappuis et al.   Molecular Metabolism

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

(2012) Laura M. Beaver et al.   PLoS One

Mitochondrial Dynamics and Apoptosis--the ER Connection

(2012) S. Hoppins et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

Daily oscillation of glutathione redox cycle is dampened in the nutritional vitamin A deficiency

(2011) Ivana Tamara Ponce et al.   BIOLOGICAL RHYTHM RESEARCH

Circadian clock protein BMAL1 regulates cellular senescence in vivo

(2011) Rohini V. Khapre et al.   CELL CYCLE

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

(2011) Jian Zhao et al.   EMBO JOURNAL

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

(2011) Tiffany Greco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

(2011) Ryan J. Mailloux et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuins at a glance

(2011) T. Nakagawa et al.   JOURNAL OF CELL SCIENCE

Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina

(2011) Cathy Chia-Yu Huang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

(2011) William C. Hallows et al.   MOLECULAR CELL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

(2011) Guillaume Rey et al.   PLOS BIOLOGY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue

(2010) Andrea Dlasková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2 and Regulates Ketone Body Production

(2010) Tadahiro Shimazu et al.   Cell Metabolism

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria

(2010) Laurence J. Toime et al.   FREE RADICAL BIOLOGY AND MEDICINE

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function

(2010) J. L. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates

(2009) Matthew D. Bruss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Glutathione, a Key Survival Antioxidant

(2009) Montserrat Marí et al.   ANTIOXIDANTS & REDOX SIGNALING

“Clocks” in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging

(2009) Shin-ichiro Imai   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders

(2008) Jian Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

Circadian regulation of response to oxidative stress in Drosophila melanogaster

(2008) Natraj Krishnan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control

(2008) Yasukazu Nakahata et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA