BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b

(2018) Changchen Xiao et al.   CIRCULATION RESEARCH

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis

(2018) Wenjun Deng et al.   Cell Reports

Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder

(2018) Marisa W. Friederich et al.   Nature Communications

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

(2018) Jung-Hoon Pyun et al.   Nature Communications

Cardiac nuclear receptors: architects of mitochondrial structure and function

(2017) Rick B. Vega et al.   JOURNAL OF CLINICAL INVESTIGATION

Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease

(2017) Faisal J. Alibhai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

(2017) Petr G. Vikhorev et al.   Scientific Reports

Mitochondrial fission and fusion

(2016) H. Lee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Pentose Phosphate Pathway Regulates the Circadian Clock

(2016) Guillaume Rey et al.   Cell Metabolism

Mitochondrial Function, Biology, and Role in Disease

(2016) Elizabeth Murphy et al.   CIRCULATION RESEARCH

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Circadian misalignment increases cardiovascular disease risk factors in humans

(2016) Christopher J. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

(2015) Moshi Song et al.   Cell Metabolism

Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal

(2015) R. E. Kreipke et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3

(2014) Meghan B. Azad et al.   Autophagy

Circadian disruption in the pathogenesis of metabolic syndrome

(2014) E. Maury et al.   DIABETES & METABOLISM

Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

(2014) Martin E. Young et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Potential Role of BNIP3 in Cardiac Remodeling, Myocardial Stiffness, and Endoplasmic Reticulum

(2013) Antoine H. Chaanine et al.   Circulation-Heart Failure

A mitochondrial bioenergetic etiology of disease

(2013) Douglas C. Wallace   JOURNAL OF CLINICAL INVESTIGATION

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Aging signaling pathways and circadian clock-dependent metabolic derangements

(2013) Maria Florencia Tevy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Development of dilated cardiomyopathy in Bmal1-deficient mice

(2012) Mellani Lefta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Circadian clock and vascular disease

(2010) Norihiko Takeda et al.   HYPERTENSION RESEARCH

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Metabolic Syndrome and Cardiovascular Risk

(2010) Salvatore Mottillo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome-Wide Profiling of the Core Clock Protein BMAL1 Targets Reveals a Strict Relationship with Metabolism

(2010) F. Hatanaka et al.   MOLECULAR AND CELLULAR BIOLOGY

Light-at-night, circadian disruption and breast cancer: assessment of existing evidence

(2009) R. G Stevens   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Circadian oscillation of nucleotide excision repair in mammalian brain

(2009) Tae-Hong Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamin A/C mutation analysis in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy

(2008) Sharie B. Parks et al.   AMERICAN HEART JOURNAL

Diurnal variations in myocardial metabolism

(2008) M. S. Bray et al.   CARDIOVASCULAR RESEARCH

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

(2007) Molly S. Bray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY