Current directions in tau research: Highlights from Tau 2020

Radiosynthesis, In Vitro and In Vivo Evaluation of [18F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies

(2021) Anton Lindberg et al.   ACS Chemical Neuroscience

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

(2021) Justin S. Sanchez et al.   Science Translational Medicine

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Elisabeth H. Thijssen et al.   NATURE MEDICINE

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

(2020) Renaud La Joie et al.   Science Translational Medicine

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

(2020) Nicolai Franzmeier et al.   Nature Communications

Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy

(2020) William G. Mantyh et al.   JAMA Neurology

Tau PET Imaging with [18F]PM-PBB3 in Frontotemporal Dementia with MAPT Mutation

(2020) Ya Su et al.   JOURNAL OF ALZHEIMERS DISEASE

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

(2020) Mihalis S. Kariolis et al.   Science Translational Medicine

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

(2020) Julie C. Ullman et al.   Science Translational Medicine

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

(2020) Nicolas R. Barthélemy et al.   Alzheimers Research & Therapy

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

(2020) Adam S. Fleisher et al.   JAMA Neurology

Imaging Tau Pathology—The Next Step

(2020) William J. Jagust   JAMA Neurology

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

(2020) Antoine Leuzy et al.   JAMA Neurology

18F-MK-6240 PET for early and late detection of neurofibrillary tangles

(2020) Tharick A Pascoal et al.   BRAIN

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers

(2020) Edmarie Guzmán-Vélez et al.   NEUROLOGY

Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy

(2020) Matthias Brendel et al.   JAMA Neurology

Sensitivity–Specificity of Tau and Amyloid β Positron Emission Tomography in Frontotemporal Lobar Degeneration

(2020) Alma Ghirelli et al.   ANNALS OF NEUROLOGY

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum

(2020) Alexis Moscoso et al.   BRAIN

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2019) Bahareh Eftekharzadeh et al.   NEURON

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

(2019) Francesco Paonessa et al.   Cell Reports

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes

(2019) Richard M. Tsai et al.   Alzheimers Research & Therapy

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

(2019) Marie Albert et al.   BRAIN

18F-Flortaucipir in TDP-43 associated frontotemporal dementia

(2019) R. Smith et al.   Scientific Reports

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

(2019) Sandra Sanabria Bohórquez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

(2019) Heiko Kroth et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Tau-positron emission tomography correlates with neuropathology findings

(2019) Val J. Lowe et al.   Alzheimers & Dementia

Dietary salt promotes cognitive impairment through tau phosphorylation

(2019) Giuseppe Faraco et al.   NATURE

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome

(2019) Richard M. Tsai et al.   JAMA Neurology

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

(2019) Celeste M. Karch et al.   Stem Cell Reports

[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series

(2019) Marta Marquié et al.   Acta Neuropathologica Communications

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology

(2019) Kaj Blennow et al.   BRAIN

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

PET imaging of tau protein targets: a methodology perspective

(2018) Cristina Lois et al.   Brain Imaging and Behavior

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

(2018) Silvana Konermann et al.   CELL

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy

(2018) A. Borreca et al.   MOLECULAR NEUROBIOLOGY

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

(2018) Wenyan Sun et al.   NATURE NEUROSCIENCE

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

A role for tau in learning, memory and synaptic plasticity

(2018) Fabrizio Biundo et al.   Scientific Reports

Tau Activates Transposable Elements in Alzheimer’s Disease

(2018) Caiwei Guo et al.   Cell Reports

Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease

(2018) Yakeel T. Quiroz et al.   JAMA Neurology

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

(2018) Jean-Philippe Courade et al.   ACTA NEUROPATHOLOGICA

Tau Protein Dysfunction after Brain Ischemia

(2018) Ryszard Pluta et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia

(2018) Jack Brelstaff et al.   Cell Reports

The involvement of tau in nucleolar transcription and the stress response

(2018) Mahmoud B. Maina et al.   Acta Neuropathologica Communications

Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

(2018) Garrett L. Cornelison et al.   AGING CELL

Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges

(2018) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

(2017) Michael C. Donohue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preclinical Evaluation of18F-RO6958948,11C-RO6931643, and11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

(2017) Michael Honer et al.   JOURNAL OF NUCLEAR MEDICINE

Current Understanding of Neurodegenerative Diseases Associated With the Protein Tau

(2017) Keith A. Josephs   MAYO CLINIC PROCEEDINGS

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

(2017) Jennifer L. Whitwell et al.   MOVEMENT DISORDERS

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

A clinicopathological approach to the diagnosis of dementia

(2017) Fanny M. Elahi et al.   Nature Reviews Neurology

18 F-AV-1451 binds to motor-related subcortical gray and white matter in corticobasal syndrome

(2017) Hanna Cho et al.   NEUROLOGY

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both

(2017) Janet Woodcock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

(2017) Elias Bou Samra et al.   Nature Communications

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

(2017) Sarah K. Kaufman et al.   Acta Neuropathologica Communications

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

(2016) Ruben Smith et al.   ACTA NEUROPATHOLOGICA

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

(2016) Corey T. McMillan et al.   ACTA NEUROPATHOLOGICA

Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment

(2016) Sofia Lopes et al.   AGING CELL

Hyperphosphorylation determines both the spread and the morphology of tau pathology

(2016) Wen Hu et al.   Alzheimers & Dementia

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy

(2016) Timothy Rittman et al.   NEUROBIOLOGY OF AGING

Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies

(2016) Benjamin Combs et al.   NEUROBIOLOGY OF DISEASE

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Imaging biomarkers in tauopathies

(2016) Melanie Dani et al.   PARKINSONISM & RELATED DISORDERS

Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement

(2016) Seung-Hye Lee et al.   Cell Reports

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

(2016) Zeyni Mansuroglu et al.   Scientific Reports

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

(2015) Muneaki Takahashi et al.   ACTA NEUROPATHOLOGICA

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Neuropathology of tauopathies: principles and practice

(2015) G. G. Kovacs   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain

(2015) Shuko Takeda et al.   Nature Communications

Passive Immunization in JNPL3 Transgenic Mice Using an Array of Phospho-Tau Specific Antibodies

(2015) Cristina d’Abramo et al.   PLoS One

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA

(2013) Sarah L. DeVos et al.   Neurotherapeutics

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Differential Diagnosis in Alzheimer’s Disease and Dementia with Lewy Bodies via VMAT2 and Amyloid Imaging

(2012) Victor L. Villemagne et al.   Neurodegenerative Diseases

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Activity Dependent Degeneration Explains Hub Vulnerability in Alzheimer's Disease

(2012) Willem de Haan et al.   PLoS Computational Biology

A neuroprotective role for the DNA damage checkpoint in tauopathy

(2011) Vikram Khurana et al.   AGING CELL

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rat tau proteome consists of six tau isoforms: implication for animal models of human tauopathies

(2009) Jozef Hanes et al.   JOURNAL OF NEUROCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Tau isoform regulation is region- and cell-specific in mouse brain

(2008) Pamela McMillan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

(2007) Tara M. Caffrey et al.   NEUROBIOLOGY OF AGING