PET imaging of tau protein targets: a methodology perspective

Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia

(2017) Young Kyoung Jang et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

(2017) Michael C. Donohue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Correlations of18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease

(2017) Ryuichi Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of18F-RO6958948,11C-RO6931643, and11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

(2017) Michael Honer et al.   JOURNAL OF NUCLEAR MEDICINE

MAO-B Inhibitors Do Not Block In Vivo Flortaucipir([18F]-AV-1451) Binding

(2017) Allan K. Hansen et al.   MOLECULAR IMAGING AND BIOLOGY

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

Applications of tau PET imaging

(2017) Nobuyuki Okamura et al.   Nature Reviews Neurology

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

(2017) Anne Maass et al.   NEUROIMAGE

Development of [11C]/[3H]THK-5351 – A potential novel carbon-11 tau imaging PET radioligand

(2017) Vladimir Stepanov et al.   NUCLEAR MEDICINE AND BIOLOGY

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

(2017) Laetitia Lemoine et al.   Alzheimers Research & Therapy

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

(2017) Kok Pin Ng et al.   Alzheimers Research & Therapy

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

EVALUATION OF TAU BURDEN IN A CROSS-SECTIONAL COHORT OF ALZHEIMER’S DISEASE SUBJECTS USING [18F]GTP1 (GENENTECH TAU PROBE 1)

(2016) Sandra Sanabria Bohorquez et al.   Alzheimers & Dementia

In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

(2016) Hanna Cho et al.   ANNALS OF NEUROLOGY

[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than “off-target” binding

(2016) Milos D. Ikonomovic et al.   ANNALS OF NEUROLOGY

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Alzheimer's disease: The amyloid hypothesis on trial

(2016) Judith R. Harrison et al.   BRITISH JOURNAL OF PSYCHIATRY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

(2016) Abbas M. Walji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reference Tissue–Based Kinetic Evaluation of 18 F-AV-1451 for Tau Imaging

(2016) Suzanne L. Baker et al.   JOURNAL OF NUCLEAR MEDICINE

Modeling Strategies for Quantification of In Vivo 18 F-AV-1451 Binding in Patients with Tau Pathology

(2016) Andreas Hahn et al.   JOURNAL OF NUCLEAR MEDICINE

Kinetic Modeling of the Tau PET Tracer 18 F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

(2016) Olivier Barret et al.   JOURNAL OF NUCLEAR MEDICINE

Kinetics of the Tau PET Tracer 18F-AV-1451 (T807) in Subjects with Normal Cognitive Function, Mild Cognitive Impairment, and Alzheimer Disease

(2016) S. Shcherbinin et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Comparison of Tau Radioligands 18 F-THK-5351 and 18 F-THK-5317

(2016) Tobey J. Betthauser et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer’s Disease Patients Measured Using [18F] THK-5351

(2016) Samuel N. Lockhart et al.   PLoS One

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Understanding the topology of 18F-AV-1451 (also known as T807) PET tau images in Alzheimer’s disease

(2015) Michael D. Devous et al.   Alzheimers & Dementia

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

(2015) Dean F. Wong et al.   Alzheimers & Dementia

T807, a reported selective tau tracer, binds with nanomolar affinity to monoamine oxidase a

(2015) Céline Vermeiren et al.   Alzheimers & Dementia

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Tau imaging in neurodegenerative diseases

(2015) M. Dani et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Quantitative imaging of protein targets in the human brain with PET

(2015) Roger N Gunn et al.   PHYSICS IN MEDICINE AND BIOLOGY

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

IN VIVO TAU IMAGING WITH 18F-THK5105 AND 18F-THK5117

(2014) Victor Villemange et al.   Alzheimers & Dementia

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET

(2014) Nobuyuki Okamura et al.   BRAIN

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

(2013) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]PBB3—a new PET ligand that identifies tau pathology in the brains of patients with AD

(2013) Heather Wood   Nature Reviews Neurology

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Characterisation of [ 18 F]-THK523, a novel in vivo tau imaging ligand

(2010) Michelle T. Fodero-Tavoletti et al.   Alzheimers & Dementia

Revisiting an Old Issue: The Discrepancy Between Tissue Ratio-Derived Binding Parameters and Kinetic Modeling-Derived Parameters After a Bolus of the Serotonin Transporter Radioligand 123I-ADAM

(2008) M. Slifstein   JOURNAL OF NUCLEAR MEDICINE

Tau exon 10 alternative splicing and tauopathies

(2008) Fei Liu et al.   Molecular Neurodegeneration