Immuno‐Engineered Nanodecoys for the Multi‐Target Anti‐Inflammatory Treatment of Autoimmune Diseases

Engineered Cytokines for Cancer and Autoimmune Disease Immunotherapy

(2021) Biaggio Uricoli et al.   Advanced Healthcare Materials

Pollen-Mimetic Metal–Organic Frameworks with Tunable Spike-Like Nanostructures That Promote Cell Interactions to Improve Antigen-Specific Humoral Immunity

(2021) Po-Ming Chen et al.   ACS Nano

Capturing Cytokines with Advanced Materials: A Potential Strategy to Tackle COVID‐19 Cytokine Storm

(2021) Qian‐Fang Meng et al.   ADVANCED MATERIALS

Structural Transformative Antioxidants for Dual‐Responsive Anti‐Inflammatory Delivery and Photoacoustic Inflammation Imaging

(2021) Caiyan Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Induction of Regulatory T Cells Via CTLA‐4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse

(2021) Gil‐Ran Kim et al.   Advanced Science

Inflammation‐Instructed Hierarchical Delivery of IL‐4/miR‐21 Orchestrates Osteoimmune Microenvironment toward the Treatment of Rheumatoid Arthritis

(2021) Yekun Deng et al.   ADVANCED FUNCTIONAL MATERIALS

An Engineered Pseudo‐Macrophage for Rapid Treatment of Bacteria‐Infected Osteomyelitis via Microwave‐Excited Anti‐Infection and Immunoregulation

(2021) Jieni Fu et al.   ADVANCED MATERIALS

Immunomodulatory nanosystems for treating inflammatory diseases

(2021) Nadim Ahamad et al.   BIOMATERIALS

Intra-articular use of radium dichloride ([223Ra] RaCl2) showed relevant anti-inflammatory response on experimental arthritis model

(2021) Luana Barbosa Corrêa et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment

(2021) Guangsheng Du et al.   JOURNAL OF CONTROLLED RELEASE

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

(2021) Shiqi Hu et al.   Nano Today

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19

(2021) Zhenhua Li et al.   Nature Nanotechnology

Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis

(2021) Qiangzhe Zhang et al.   Nature Communications

Human islet T cells are highly reactive to preproinsulin in type 1 diabetes

(2021) Amanda M. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis

(2021) Yang Zhou et al.   Science Advances

Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis

(2020) Yusuke Takeuchi et al.   IMMUNOLOGICAL REVIEWS

Engineered PD‐L1‐Expressing Platelets Reverse New‐Onset Type 1 Diabetes

(2020) Xudong Zhang et al.   ADVANCED MATERIALS

A Biomimetic Nanoparticle to “Lure and Kill” Phospholipase A2

(2020) Qiangzhe Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

(2020) Lars Fugger et al.   CELL

A Simple and Effective Flow Cytometry-Based Method for Identification and Quantification of Tissue Infiltrated Leukocyte Subpopulations in a Mouse Model of Peripheral Arterial Disease

(2020) Konda Kumaraswami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRAIL-expressing cell membrane nanovesicles as an anti-inflammatory platform for rheumatoid arthritis therapy

(2020) Yesi Shi et al.   JOURNAL OF CONTROLLED RELEASE

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

(2020) Brian Diskin et al.   NATURE IMMUNOLOGY

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

(2020) Cheng Gao et al.   Nature Communications

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

(2020) Wen‐Long Liu et al.   ADVANCED FUNCTIONAL MATERIALS

Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.

(2020) Dimas Abdirama et al.   KIDNEY INTERNATIONAL

Autoimmune and inflammatory diseases following COVID-19

(2020) Caroline Galeotti et al.   Nature Reviews Rheumatology

A highly potent lymphatic system–targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus

(2020) Raghu Ganugula et al.   Science Advances

Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

(2020) Lang Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

(2020) Qi Peng et al.   Nature Communications

Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

(2019) Xin Xu et al.   Nano Research

A new class of biological materials: Cell membrane-derived hydrogel scaffolds

(2019) Zhiyuan Fan et al.   BIOMATERIALS

Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells

(2019) Wen‐Long Liu et al.   ADVANCED MATERIALS

Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections

(2019) Chi Zhang et al.   ADVANCED MATERIALS

SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes

(2019) Seung Jin Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model

(2019) Ping Song et al.   MOLECULAR THERAPY

Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis

(2019) Gabriela Kania et al.   Nature Reviews Rheumatology

Engineering Cell Membrane‐Based Nanotherapeutics to Target Inflammation

(2019) Huize Yan et al.   Advanced Science

Inhibition of Pathogen Adhesion by Bacterial Outer Membrane-Coated Nanoparticles

(2019) Yue Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

(2019) Chenwen Li et al.   Advanced Science

Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Diseases Caused by TTC7A Deficiency

(2019) Sasha Jardine et al.   GASTROENTEROLOGY

Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies

(2019) Kiyomitsu Katsumata et al.   Science Advances

Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

(2018) Zhiyuan Fan et al.   Nano Research

Approaches and advances in the genetic causes of autoimmune disease and their implications

(2018) Jamie R. J. Inshaw et al.   NATURE IMMUNOLOGY

Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiota

(2018) Ce Tang et al.   NATURE IMMUNOLOGY

T-Cell-Mimicking Nanoparticles Can Neutralize HIV Infectivity

(2018) Xiaoli Wei et al.   ADVANCED MATERIALS

In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2S donor on the colorectal surface to treat inflammatory bowel diseases

(2018) Wei-Chih Lin et al.   BIOMATERIALS

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

(2018) Ruixiang Li et al.   NANO LETTERS

Cell‐Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen‐Presenting Cells for T Cell Activation

(2018) Brynn R. Olden et al.   Advanced Healthcare Materials

Autoreactive T cells in type 1 diabetes

(2017) Alberto Pugliese   JOURNAL OF CLINICAL INVESTIGATION

BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

(2017) Kalung Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

(2017) Soracha Thamphiwatana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

(2017) Nirit Mor-Vaknin et al.   Nature Communications

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins

(2016) Xi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease

(2016) Qixiong Zhang et al.   BIOMATERIALS

NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1Novelty and Significance

(2016) Yuhong Luo et al.   CIRCULATION RESEARCH

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration

(2016) Drew L. Sellers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

(2016) Hendrik B. Sager et al.   Science Translational Medicine

A Facile Approach to Functionalize Cell Membrane-Coated Nanoparticles

(2016) Hao Zhou et al.   Theranostics

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

(2016) Yuichi Maeda et al.   Arthritis & Rheumatology

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways

(2015) Cuiping Liu et al.   ARTHRITIS RESEARCH & THERAPY

Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period

(2014) Paul Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Clearance of pathological antibodies using biomimetic nanoparticles

(2014) Jonathan A. Copp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation-Induced Drug Release by using a pH-Responsive Gas-Generating Hollow-Microsphere System for the Treatment of Osteomyelitis

(2014) Ming-Fan Chung et al.   Advanced Healthcare Materials

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

Emerging cell and cytokine targets in rheumatoid arthritis

(2013) Gerd R. Burmester et al.   Nature Reviews Rheumatology

IL10 Released by a New Inflammation-regulated Lentiviral System Efficiently Attenuates Zymosan-induced Arthritis

(2012) Guillermo Garaulet et al.   MOLECULAR THERAPY

Activation of p38 Mitogen-Activated Protein Kinase Is Inhibited by Hyaluronan via Intercellular Adhesion Molecule-1 in Articular Chondrocytes Stimulated With Type II Collagen Peptide

(2011) Tadashi Yasuda   JOURNAL OF PHARMACOLOGICAL SCIENCES

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

(2010) Stewart Leung et al.   Cellular & Molecular Immunology

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Calcineurin Inhibitor Nephrotoxicity

(2009) M. Naesens et al.   Clinical Journal of the American Society of Nephrology

Targeted depletion of lymphotoxin-α–expressing TH1 and TH17 cells inhibits autoimmune disease

(2009) Eugene Y Chiang et al.   NATURE MEDICINE