Human islet T cells are highly reactive to preproinsulin in type 1 diabetes

One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

(2021) Teresa Rodriguez-Calvo et al.   DIABETES

Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors

(2021) Laurie G. Landry et al.   Frontiers in Endocrinology

Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System

(2020) Sarah E. Mann et al.   Frontiers in Immunology

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

(2020) Eddie A. James et al.   DIABETES

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes

(2020) Tatjana Nikolic et al.   Lancet Diabetes & Endocrinology

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes

(2020) Christine Bender et al.   Science Advances

The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

(2019) Anthony W. Purcell et al.   DIABETES

Hybrid Insulin Peptides are Autoantigens in Type 1 Diabetes

(2019) R.L. Baker et al.   DIABETES

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes

(2019) Laura A. Claessens et al.   DIABETOLOGIA

Changing the landscape for type 1 diabetes: the first step to prevention

(2019) Colin M Dayan et al.   LANCET

Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

(2019) Alice E. Wiedeman et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway

(2019) Stuart P. Weisberg et al.   Cell Reports

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

(2018) Lorraine Yeo et al.   JOURNAL OF CLINICAL INVESTIGATION

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes

(2018) Marcela Brissova et al.   Cell Reports

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

The challenge of modulating β-cell autoimmunity in type 1 diabetes

(2018) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

(2018) Bart O Roep et al.   Lancet Diabetes & Endocrinology

Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes

(2017) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

(2017) Mohammad Alhadj Ali et al.   Science Translational Medicine

Characterization of resident lymphocytes in human pancreatic islets

(2016) M. Radenkovic et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

(2016) Sarah J. Richardson et al.   DIABETOLOGIA

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes

(2015) Ezio Bonifacio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

(2014) Vimukthi Pathiraja et al.   DIABETES

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings

(2013) Alberto Pugliese et al.   PEDIATRIC DIABETES

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

HLA-B7-Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes

(2012) M. Scotto et al.   DIABETES

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Zinc transporter (ZnT)8186–194 is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients

(2012) M. Scotto et al.   DIABETOLOGIA

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

HLA Class I and Genetic Susceptibility to Type 1 Diabetes: Results From the Type 1 Diabetes Genetics Consortium

(2010) J. A. Noble et al.   DIABETES

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Genetics of Type 1A Diabetes

(2009) Patrick Concannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET