Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis

Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism

(2018) Cristina Municio et al.   ANNALS OF THE RHEUMATIC DISEASES

Changes in macrophage transcriptome associate with systemic sclerosis and mediateGSDMAcontribution to disease risk

(2018) Aida Moreno-Moral et al.   ANNALS OF THE RHEUMATIC DISEASES

Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis

(2018) Stefano Soldano et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis

(2018) Hidetake Nagahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autologous hematopoietic stem cell transplantation in systemic sclerosis: A reset to tolerance?

(2018) Femke C.C. van Rhijn-Brouwer et al.   IMMUNOLOGY LETTERS

Dendritic cells in systemic sclerosis: Advances from human and mice studies

(2018) Alsya J. Affandi et al.   IMMUNOLOGY LETTERS

High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

(2018) Carsten Krieg et al.   NATURE MEDICINE

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

(2018) Marie Dominique Ah Kioon et al.   Science Translational Medicine

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation

(2017) Yunjuan Nie et al.   JOURNAL OF IMMUNOLOGY

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

(2017) Jaclyn N. Taroni et al.   Genome Medicine

Interfacial Adipose Tissue in Systemic Sclerosis

(2017) Ilja L. Kruglikov   Current Rheumatology Reports

Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis

(2017) Marzia Rossato et al.   Arthritis & Rheumatology

Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

(2017) Ehab A. Ayaub et al.   Scientific Reports

Update of EULAR recommendations for the treatment of systemic sclerosis

(2016) Otylia Kowal-Bielecka et al.   ANNALS OF THE RHEUMATIC DISEASES

Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients

(2016) L Michel et al.   BONE MARROW TRANSPLANTATION

A potential contribution of antimicrobial peptide LL-37 to tissue fibrosis and vasculopathy in systemic sclerosis

(2016) T. Takahashi et al.   BRITISH JOURNAL OF DERMATOLOGY

Reassessing the Role of the Active TGF-β1 as a Biomarker in Systemic Sclerosis: Association of Serum Levels with Clinical Manifestations

(2016) Andréa Tavares Dantas et al.   DISEASE MARKERS

Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

(2016) Jennifer L. Larson-Casey et al.   IMMUNITY

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

Dendritic cells maintain dermal adipose–derived stromal cells in skin fibrosis

(2016) Jennifer J. Chia et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease

(2016) Tracy A. Delaney et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial

(2016) Dinesh Khanna et al.   LANCET

Identification of an atypical monocyte and committed progenitor involved in fibrosis

(2016) Takashi Satoh et al.   NATURE

Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury

(2016) Hidetake Nagahara et al.   BioScience Trends

Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2

(2016) Marzena Ciechomska et al.   Arthritis & Rheumatology

Review: Hematopoietic Stem Cell Transplantation for Scleroderma: Effective Immunomodulatory Therapy for Patients With Pulmonary Involvement

(2016) Keith M. Sullivan et al.   Arthritis & Rheumatology

FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Role in Dermal Fibrosis and Lipoatrophy

(2015) Vanessa Martins et al.   AMERICAN JOURNAL OF PATHOLOGY

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies

(2015) Clara Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis

(2015) Jingang Huang et al.   ANNALS OF THE RHEUMATIC DISEASES

Update on macrophages and innate immunity in scleroderma

(2015) Jennifer J. Chia et al.   CURRENT OPINION IN RHEUMATOLOGY

Oligosaccharide modification byN-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma

(2015) Arisa Kato et al.   EXPERIMENTAL DERMATOLOGY

Deciphering the alternatively activated (M2) phenotype of macrophages in scleroderma

(2015) Mirko Manetti   EXPERIMENTAL DERMATOLOGY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

(2015) Neele Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

(2015) Lisa M. Rice et al.   JOURNAL OF CLINICAL INVESTIGATION

Haematopoietic stem cell transplantation for poor-prognosis systemic sclerosis

(2015) J. M. van Laar et al.   RHEUMATOLOGY

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

(2015) J. Matthew Mahoney et al.   PLoS Computational Biology

Macrophage Involvement in Systemic Sclerosis: Do We Need More Evidence?

(2015) Giuseppina Stifano et al.   Current Rheumatology Reports

Systemic sclerosis

(2015) Yannick Allanore et al.   Nature Reviews Disease Primers

ADAM10 and ADAM17: New Players in Trastuzumab Resistance

(2015) Michael J. Duffy et al.   Oncotarget

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis

(2014) J. Schupp et al.   EUROPEAN RESPIRATORY JOURNAL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

(2014) Charlotte Giesen et al.   NATURE METHODS

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Increased expression of chemerin in endothelial cells due to Fli1 deficiency may contribute to the development of digital ulcers in systemic sclerosis

(2014) Kaname Akamata et al.   RHEUMATOLOGY

Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study

(2014) Paolo Fraticelli et al.   ARTHRITIS RESEARCH & THERAPY

Caveolin-1 Deficiency May Predispose African Americans to Systemic Sclerosis-Related Interstitial Lung Disease

(2014) Charles Reese et al.   Arthritis & Rheumatology

Human Dendritic Cell Functional Specialization in Steady-State and Inflammation

(2014) Arjan Boltjes et al.   Frontiers in Immunology

Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin

(2013) Allison L Mathes et al.   ANNALS OF THE RHEUMATIC DISEASES

A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis

(2013) Alicia Usategui et al.   ANNALS OF THE RHEUMATIC DISEASES

Skin Gene Expression Correlates of Severity of Interstitial Lung Disease in Systemic Sclerosis

(2013) Shervin Assassi et al.   ARTHRITIS AND RHEUMATISM

Organization of the mouse and human DC network

(2013) Andreas Schlitzer et al.   CURRENT OPINION IN IMMUNOLOGY

Preclinical and translational research to discover potentially effective antifibrotic therapies in systemic sclerosis

(2013) Suzana Jordan et al.   CURRENT OPINION IN RHEUMATOLOGY

Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin

(2013) Samira Tamoutounour et al.   IMMUNITY

Maturation of Lymph Node Fibroblastic Reticular Cells from Myofibroblastic Precursors Is Critical for Antiviral Immunity

(2013) Qian Chai et al.   IMMUNITY

Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

(2013) Adam C. Midgley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory dendritic cells in mice and humans

(2013) Elodie Segura et al.   TRENDS IN IMMUNOLOGY

Identification of Cadherin 11 as a Mediator of Dermal Fibrosis and Possible Role in Systemic Sclerosis

(2013) Minghua Wu et al.   Arthritis & Rheumatology

Association of Interferon- and Transforming Growth Factor β-Regulated Genes and Macrophage Activation With Systemic Sclerosis-Related Progressive Lung Fibrosis

(2013) Romy B. Christmann et al.   Arthritis & Rheumatology

Oxidative stress induced by the chemotherapeutic agent arsenic trioxide

(2013) Mathews V. Varghese et al.   3 Biotech

Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis

(2012) Britta Maurer et al.   ANNALS OF THE RHEUMATIC DISEASES

Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

(2012) Marzena Ciechomska et al.   ANNALS OF THE RHEUMATIC DISEASES

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair

(2012) Maciej Lech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

GM-CSF promotes inflammatory dendritic cell formation but does not contribute to disease progression in experimental autoimmune myocarditis

(2012) Przemyslaw Blyszczuk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Zbtb46expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

(2012) Ansuman T. Satpathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arsenic Trioxide Prevents Murine Sclerodermatous Graft-versus-Host Disease

(2012) N. Kavian et al.   JOURNAL OF IMMUNOLOGY

Differentiation Potential of CD14+ Monocytes into Myofibroblasts in Patients with Systemic Sclerosis

(2012) Nadine Binai et al.   PLoS One

T cells in systemic sclerosis: a reappraisal

(2012) S. O'Reilly et al.   RHEUMATOLOGY

Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension

(2011) Romy B. Christmann et al.   ARTHRITIS AND RHEUMATISM

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition

(2011) Daniel J. Schneider et al.   FASEB JOURNAL

Serum Interleukin 9 Levels Are Increased in Patients with Systemic Sclerosis: Association with Lower Frequency and Severity of Pulmonary Fibrosis

(2011) KOICHI YANABA et al.   JOURNAL OF RHEUMATOLOGY

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

(2011) P. Pacher et al.   PROGRESS IN LIPID RESEARCH

Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis

(2011) Bradley J Rabquer et al.   ARTHRITIS RESEARCH & THERAPY

Animal models of systemic sclerosis: Prospects and limitations

(2010) Christian Beyer et al.   ARTHRITIS AND RHEUMATISM

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Dendritic cells and humoral immunity in humans

(2010) Hideki Ueno et al.   IMMUNOLOGY AND CELL BIOLOGY

Allograft inflammatory factor-1 is overexpressed and induces fibroblast chemotaxis in the skin of sclerodermatous GVHD in a murine model

(2010) Aihiro Yamamoto et al.   IMMUNOLOGY LETTERS

Immunotherapy of systemic sclerosis

(2010) Rebecca Manno et al.   Immunotherapy

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse CD8α+DCs and human BDCA3+DCs are major producers of IFN-λ in response to poly IC

(2010) Henning Lauterbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis

(2010) Giuseppina A. Farina et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype

(2010) Susan K Mathai et al.   LABORATORY INVESTIGATION

Type I interferons: crucial participants in disease amplification in autoimmunity

(2010) John C. Hall et al.   Nature Reviews Rheumatology

Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells

(2010) H. Tsukamoto et al.   RHEUMATOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Mechanisms of Cardiac Fibrosis in Inflammatory Heart Disease

(2010) Gabriela Kania et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis

(2010) Nobuyo Higashi-Kuwata et al.   ARTHRITIS RESEARCH & THERAPY

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

(2009) Nicole Reich et al.   ARTHRITIS AND RHEUMATISM

The role of innate immune responses in autoimmune disease development

(2009) Hanspeter Waldner   AUTOIMMUNITY REVIEWS

Transcription Factor Fos-Related Antigen-2 Induces Progressive Peripheral Vasculopathy in Mice Closely Resembling Human Systemic Sclerosis

(2009) Britta Maurer et al.   CIRCULATION

Myeloid Differentiation Factor-88/Interleukin-1 Signaling Controls Cardiac Fibrosis and Heart Failure Progression in Inflammatory Dilated Cardiomyopathy

(2009) Przemyslaw Blyszczuk et al.   CIRCULATION RESEARCH

Heart-Infiltrating Prominin-1 + /CD133 + Progenitor Cells Represent the Cellular Source of Transforming Growth Factor β–Mediated Cardiac Fibrosis in Experimental Autoimmune Myocarditis

(2009) Gabriela Kania et al.   CIRCULATION RESEARCH

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension

(2009) F. Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis

(2009) Catherine A Shaw et al.   Journal of Inflammation-London

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma

(2008) Hangjun Duan et al.   ARTHRITIS AND RHEUMATISM

Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial

(2008) Clarissa E. Vergunst et al.   ARTHRITIS AND RHEUMATISM

PDE4 inhibitors: current status

(2008) D Spina   BRITISH JOURNAL OF PHARMACOLOGY

T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis

(2008) Carlo Chizzolini   CURRENT OPINION IN RHEUMATOLOGY

Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2

(2008) Lynne A. Murray et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Implication of N-Acetylglucosaminyl- transferase V Expression in Gastric Cancer

(2008) Hai Tian et al.   PATHOBIOLOGY

Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis

(2008) J. H. W. Distler et al.   RHEUMATOLOGY

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

(2007) Yannick Marchalant et al.   NEUROBIOLOGY OF AGING