Emerging cell and cytokine targets in rheumatoid arthritis

FRI0197 NNC0109-0012 (anti-IL-20 MAB), well tolerated in patients with rheumatoid arthritis

(2014) P. Leszczyński et al.   ANNALS OF THE RHEUMATIC DISEASES

FRI0196 NNC0109-0012 (anti-IL-20 MAB), well tolerated in healthy subjects and patients with rheumatoid arthritis

(2014) N. Al Kotbi et al.   ANNALS OF THE RHEUMATIC DISEASES

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nuclear Receptor NR4A2 Orchestrates Th17 Cell-Mediated Autoimmune Inflammation via IL-21 Signalling

(2013) Ben J. E. Raveney et al.   PLoS One

Small molecules targeting JAKs--a new approach in the treatment of rheumatoid arthritis

(2013) E. Feist et al.   RHEUMATOLOGY

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Alemtuzumab: evidence for its potential in relapsing–remitting multiple sclerosis

(2013) William Brown et al.   Drug Design Development and Therapy

Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort

(2012) Jacques-Eric Gottenberg et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trial

(2012) William Stohl et al.   ANNALS OF THE RHEUMATIC DISEASES

Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial

(2012) Paul P Tak et al.   ANNALS OF THE RHEUMATIC DISEASES

Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus

(2012) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study

(2012) Mark C Genovese et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Induced T regulatory cells suppress osteoclastogenesis and bone erosion in collagen-induced arthritis better than natural T regulatory cells

(2012) Ning Kong et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: Results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial

(2012) P. P. Tak et al.   ARTHRITIS AND RHEUMATISM

CD22 ligation inhibits downstream B cell receptor signaling and Ca2+flux upon activation

(2012) N. Sieger et al.   ARTHRITIS AND RHEUMATISM

Tregitope update: Mechanism of action parallels IVIg

(2012) Leslie P. Cousens et al.   AUTOIMMUNITY REVIEWS

MicroRNAs in Rheumatoid Arthritis

(2012) Mária Filková et al.   BIODRUGS

Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study

(2012) P. Rich et al.   BRITISH JOURNAL OF DERMATOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

B-cell depletion in the treatment of lupus nephritis

(2012) Jon W. Gregersen et al.   Nature Reviews Nephrology

The pathogenesis of rheumatoid arthritis: new insights from old clinical data?

(2012) Josef S. Smolen et al.   Nature Reviews Rheumatology

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Alveolar Proteinosis

(2012) Tisha Wang et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity

(2012) Henrik E Mei et al.   ARTHRITIS RESEARCH & THERAPY

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis

(2011) M. H. Buch et al.   ANNALS OF THE RHEUMATIC DISEASES

Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial

(2011) P. C. Taylor et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis

(2011) Seung-Ki Kwok et al.   ARTHRITIS AND RHEUMATISM

Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies

(2011) W. Alduaij et al.   BLOOD

Anti–IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss

(2011) Yu-Hsiang Hsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Alveolar Proteinosis

(2011) A. Khan et al.   Respiratory Care

Therapeutic potential of Tregs to treat rheumatoid arthritis

(2011) Graham P. Wright et al.   SEMINARS IN IMMUNOLOGY

Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis

(2010) C. Salliot et al.   ANNALS OF THE RHEUMATIC DISEASES

Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: Results of a randomized, double-blind, placebo-controlled, phase I/II study

(2010) Mikkel Østergaard et al.   ARTHRITIS AND RHEUMATISM

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

IL-21 regulates Th17 cells in rheumatoid arthritis

(2010) Xiaoyin Niu et al.   HUMAN IMMUNOLOGY

Increased Interleukin 21 (IL-21) and IL-23 Are Associated with Increased Disease Activity and with Radiographic Status in Patients with Early Rheumatoid Arthritis

(2010) T. K. RASMUSSEN et al.   JOURNAL OF RHEUMATOLOGY

Regulatory B cells in autoimmunity: developments and controversies

(2010) Claudia Mauri et al.   Nature Reviews Rheumatology

Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis

(2010) Rachel B. Jones et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

(2010) Thomas Dörner et al.   PHARMACOLOGY & THERAPEUTICS

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Multitude of Kinases—Which are the Best Targets in Treating Rheumatoid Arthritis?

(2010) Tamsin M. Lindstrom et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Ten years with biologics: to whom do data on effectiveness and safety apply?

(2010) J. F. Simard et al.   RHEUMATOLOGY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B-cells in systemic lupus erythematosus

(2010) Capucine Daridon et al.   ARTHRITIS RESEARCH & THERAPY

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview

(2009) J. A. Singh et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis

(2009) Y. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Plasticity of CD4+ FoxP3+ T cells

(2009) Xuyu Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

Antibodies to citrullinated proteins in arthritis: pathology and promise

(2009) Lars Klareskog et al.   CURRENT OPINION IN RHEUMATOLOGY

Regulatory T cells as therapeutic targets in rheumatoid arthritis

(2009) Jonathan H. Esensten et al.   Nature Reviews Rheumatology

B-cell-directed therapies for autoimmune disease

(2009) Thomas Dörner et al.   Nature Reviews Rheumatology

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus

(2009) B. C.-H. Kwan et al.   RHEUMATOLOGY

Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs

(2009) Claudia Mauri et al.   ARTHRITIS RESEARCH & THERAPY

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

(2008) Lars Klareskog et al.   Annual Review of Immunology

Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: Twelve-year outcomes

(2008) Alice R. Lorenzi et al.   ARTHRITIS AND RHEUMATISM

Co-stimulatory modulation in rheumatoid arthritis: The role of (CTLA4-Ig) abatacept

(2008) Ugo Fiocco et al.   AUTOIMMUNITY REVIEWS

Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

(2008) H. M. Horton et al.   CANCER RESEARCH

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL

CD4+CD25high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis

(2008) Guang Ming Han et al.   CELLULAR IMMUNOLOGY

An overview of IL-17 function and signaling

(2008) Sarah L. Gaffen   CYTOKINE

Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

(2008) Malini Bajpai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody

(2008) R. Bargou et al.   SCIENCE

The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy

(2007) Tue Wenzel Kragstrup et al.   CYTOKINE