Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

(2019) Mattias N.D. Svensson et al.   JOURNAL OF CLINICAL INVESTIGATION

Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation

(2019) Takashi Matsuo et al.   JOURNAL OF IMMUNOLOGY

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

(2019) Judith F. Ashouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

(2019) Wen-Yi Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

(2018) Keiji Hirota et al.   IMMUNITY

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis

(2018) Jan Piet van Hamburg et al.   JOURNAL OF AUTOIMMUNITY

The SKG model of spondyloarthritis

(2018) M. Arifur Rahman et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond

(2018) Nicolo Costantino Brembilla et al.   Frontiers in Immunology

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis

(2017) Michael E. Weinblatt et al.   Arthritis & Rheumatology

The Role of the Intestinal Microbiome in Type 1 Diabetes Pathogenesis

(2016) James C. Needell et al.   Current Diabetes Reports

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

(2016) Fei Teng et al.   IMMUNITY

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70

(2016) Alice Y. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice

(2016) Shatakshi Sood et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains

(2016) S. Guerard et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

(2016) Yuichi Maeda et al.   Arthritis & Rheumatology

Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice

(2016) Eric V. Marietta et al.   Arthritis & Rheumatology

The interleukin (IL)-23/IL-17 axis in ankylosing spondylitis: new advances and potentials for treatment

(2015) H. Jethwa et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Paradoxical Expansion of Th1 and Th17 Lymphocytes in Rheumatoid Arthritis Following Infliximab Treatment: a Possible Explanation for a Lack of Clinical Response

(2015) Rossella Talotta et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease

(2015) Robert C. Sharp et al.   Frontiers in Cellular and Infection Microbiology

Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

(2015) Sachiko Miyake et al.   PLoS One

MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

(2014) Frank Behrens et al.   ANNALS OF THE RHEUMATIC DISEASES

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells

(2014) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease

(2014) Y. Ito et al.   SCIENCE

Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

(2013) Nunzio Bottini et al.   Annual Review of Immunology

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

(2013) Keiji Hirota et al.   NATURE IMMUNOLOGY

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

(2013) Jose U Scher et al.   eLife

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

(2012) Merja Ruutu et al.   ARTHRITIS AND RHEUMATISM

T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man

(2012) Shimon Sakaguchi et al.   IMMUNOLOGY AND CELL BIOLOGY

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease

(2012) SuJin Hwang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PTPN22 Alters the Development of Regulatory T Cells in the Thymus

(2012) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

(2012) A. Zanin-Zhorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SLAP Deficiency Enhances Number and Function of Regulatory T Cells Preventing Chronic Autoimmune Arthritis in SKG Mice

(2011) L. K. Peterson et al.   JOURNAL OF IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

Complement drives Th17 cell differentiation and triggers autoimmune arthritis

(2010) Motomu Hashimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

(2010) S. Tanaka et al.   JOURNAL OF IMMUNOLOGY

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

(2010) Yuta Kochi et al.   NATURE GENETICS

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

ZAP70: a master regulator of adaptive immunity

(2010) Alain Fischer et al.   Seminars in Immunopathology

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis

(2009) Yoshinaga Ito et al.   ARTHRITIS AND RHEUMATISM

Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis

(2009) Gabriel Criado et al.   ARTHRITIS AND RHEUMATISM

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Hypomorphic mutation ofZAP70in human results in a late onset immunodeficiency and no autoimmunity

(2009) Capucine Picard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

(2009) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

(2009) Lih-Yun Hsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology

(2008) A. Curti et al.   BLOOD

Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency

(2008) Tuba Turul et al.   EUROPEAN JOURNAL OF PEDIATRICS

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY