Mechanotransduction assays for neural regeneration strategies: A focus on glial cells

Hyaluronan‐based hydrogels as versatile tumor‐like models: Tunable ECM and stiffness with genipin‐crosslinking

(2020) Sarah Bonnesœur et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Role and Regulatory Mechanism of Hippo Signaling Components in the Neuronal System

(2020) Jinbo Cheng et al.   Frontiers in Immunology

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

(2020) Zhongyang Liu et al.   Frontiers in Chemistry

Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP‐Dependent Regulation

(2020) William Ong et al.   Small

Mechanobiology of neural development

(2020) Hamid Abuwarda et al.   CURRENT OPINION IN CELL BIOLOGY

Matrix Remodeling Enhances the Differentiation Capacity of Neural Progenitor Cells in 3D Hydrogels

(2019) Christopher M. Madl et al.   Advanced Science

Acute and chronic demyelinated CNS lesions exhibit opposite elastic properties

(2019) Mateusz M. Urbanski et al.   Scientific Reports

Neural tissue engineering with structured hydrogels in CNS models and therapies

(2019) Julian George et al.   BIOTECHNOLOGY ADVANCES

Consideration of the Mechanical Properties of Hydrogels for Brain Tissue Engineering and Brain-on-a-chip

(2019) Hong Nam Kim et al.   BioChip Journal

Fabrication of Designable and Suspended Microfibers via Low-Voltage 3D Micropatterning

(2019) Elisabeth L. Gill et al.   ACS Applied Materials & Interfaces

Three-Motorized-Stage Cyclic Stretching System for Cell Monitoring Based on Chamber Local Displacement Waveforms

(2019) Wenjing Huang et al.   Applied Sciences-Basel

Manipulation of Extracellular Matrix Remodeling and Neurite Extension by Mouse Embryonic Stem Cells Using IKVAV and LRE Peptide Tethering in Hyaluronic Acid Matrices

(2019) T. Hiran Perera et al.   BIOMACROMOLECULES

Development of glial restricted human neural stem cells for oligodendrocyte differentiation in vitro and in vivo

(2019) Sangita Biswas et al.   Scientific Reports

Innovative Tools for Mechanobiology: Unraveling Outside-In and Inside-Out Mechanotransduction

(2019) Danahe Mohammed et al.   Frontiers in Bioengineering and Biotechnology

Piezo1 regulates calcium oscillations and cytokine release from astrocytes

(2019) María Velasco‐Estevez et al.   GLIA

Influence of Age on Global and Regional Brain Stiffness in Young and Middle‐Aged Adults

(2019) Tomohiro Takamura et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Inhibition of Piezo1 attenuates demyelination in the central nervous system

(2019) María Velasco‐Estevez et al.   GLIA

Cellular responses to beating hydrogels to investigate mechanotransduction

(2019) Yashoda Chandorkar et al.   Nature Communications

Characterizing viscoelastic mechanical properties of highly compliant polymers and biological tissues using impact indentation

(2018) Aleksandar S. Mijailovic et al.   Acta Biomaterialia

Microfiber drug/gene delivery platform for study of myelination

(2018) William Ong et al.   Acta Biomaterialia

A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons

(2018) Andy Tay et al.   ADVANCED MATERIALS

Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice

(2018) Marcel Levy Nogueira et al.   Alzheimers & Dementia

Crosstalk between glia, extracellular matrix and neurons

(2018) Inseon Song et al.   BRAIN RESEARCH BULLETIN

Brain stiffens post mortem

(2018) J. Weickenmeier et al.   Journal of the Mechanical Behavior of Biomedical Materials

Pneumatically actuated cell-stretching array platform for engineering cell patterns in vitro

(2018) Harshad Kamble et al.   LAB ON A CHIP

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

(2018) Eduarda G Z Centeno et al.   Molecular Neurodegeneration

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Regulation of neuritogenesis in hippocampal neurons using stiffness of extracellular microenvironment

(2018) Aya Tanaka et al.   PLoS One

Mechanical Strain Alters Cellular and Nuclear Dynamics at Early Stages of Oligodendrocyte Differentiation

(2018) Ekta Makhija et al.   Frontiers in Cellular Neuroscience

Myelinating Schwann Cell Polarity and Mechanically-Driven Myelin Sheath Elongation

(2018) Nicolas Tricaud   Frontiers in Cellular Neuroscience

Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

(2018) Liqun Wang et al.   Nature Communications

Engineered 3D-printed artificial axons

(2018) Daniela Espinosa-Hoyos et al.   Scientific Reports

Polyethylene glycol–gelatin hydrogels with tuneable stiffness prepared by horseradish peroxidase-activated tetrazine–norbornene ligation

(2018) J. Carthew et al.   Journal of Materials Chemistry B

Alzheimer’s Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea

(2018) Maria José Menal et al.   Frontiers in Neurology

Hydrolytically-degradable click-crosslinked alginate hydrogels

(2018) Aline Lueckgen et al.   BIOMATERIALS

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

mTOR regulates peripheral nerve response to tensile strain

(2017) James M. Love et al.   JOURNAL OF NEUROPHYSIOLOGY

The mechanical importance of myelination in the central nervous system

(2017) Johannes Weickenmeier et al.   Journal of the Mechanical Behavior of Biomedical Materials

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial

(2017) Ari J Green et al.   LANCET

Effects of an injectable functionalized self-assembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system

(2017) Tzu-Wei Wang et al.   Nanoscale

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells

(2017) Abdolrahman Omidinia-Anarkoli et al.   Small

Superparamagnetic Iron Oxide Nanoparticle-Mediated Forces Enhance the Migration of Schwann Cells Across the Astrocyte-Schwann Cell Boundary In vitro

(2017) Liangliang Huang et al.   Frontiers in Cellular Neuroscience

Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression

(2017) Anna Jagielska et al.   Frontiers in Cellular Neuroscience

The soft mechanical signature of glial scars in the central nervous system

(2017) Emad Moeendarbary et al.   Nature Communications

Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology is Dependent on Mesh Size and Storage Modulus in 3D Poly(ethylene glycol)-Based Hydrogels

(2017) Lauren N. Russell et al.   ACS Biomaterials-Science & Engineering

Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology is Dependent on Mesh Size and Storage Modulus in 3D Poly(ethylene glycol)-Based Hydrogels

(2017) Lauren N. Russell et al.   ACS Biomaterials Science & Engineering

Bioengineered 3D Glial Cell Culture Systems and Applications for Neurodegeneration and Neuroinflammation

(2017) P. Marc D. Watson et al.   SLAS Discovery

Tuning the Range of Polyacrylamide Gel Stiffness for Mechanobiology Applications

(2016) Aleksandra K. Denisin et al.   ACS Applied Materials & Interfaces

Brain stiffness increases with myelin content

(2016) J. Weickenmeier et al.   Acta Biomaterialia

Mechanical stress related to brain atrophy in Alzheimer's disease

(2016) Marcel Levy Nogueira et al.   Alzheimers & Dementia

Statistical study of biomechanics of living brain cells during growth and maturation on artificial substrates

(2016) La Chen et al.   BIOMATERIALS

Development of a central nervous system axonal myelination assay for high throughput screening

(2016) Karen D. Lariosa-Willingham et al.   BMC NEUROSCIENCE

YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation

(2016) Takeshi Shimizu et al.   GLIA

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

(2016) Arupratan Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice

(2016) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes

(2016) M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

A potential role for glia-derived extracellular matrix remodeling in postinjury epilepsy

(2016) Soo Young Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration

(2016) Kritika S. Katiyar et al.   Journal of Tissue Engineering and Regenerative Medicine

Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review

(2016) Ratima Suntornnond et al.   MACROMOLECULAR MATERIALS AND ENGINEERING

Remote Magnetic Orientation of 3D Collagen Hydrogels for Directed Neuronal Regeneration

(2016) Merav Antman-Passig et al.   NANO LETTERS

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

(2016) Yannick Poitelon et al.   NATURE NEUROSCIENCE

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development

(2016) Swarnalatha Balasubramanian et al.   TISSUE ENGINEERING PART A

Mechanotransduction of Neural Cells Through Cell–Substrate Interactions

(2016) Jessica M. Stukel et al.   TISSUE ENGINEERING PART B-REVIEWS

Myelinating glia differentiation is regulated by extracellular matrix elasticity

(2016) Mateusz M. Urbanski et al.   Scientific Reports

Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche

(2016) Eun Hyuk Chang et al.   Frontiers in Neuroscience

Regional brain stiffness changes across the Alzheimer's disease spectrum

(2016) Matthew C. Murphy et al.   NeuroImage-Clinical

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues

(2016) Tânia Lourenço et al.   Scientific Reports

Actomyosin contractility plays a role in MAP2 expression during nanotopography-directed neuronal differentiation of human embryonic stem cells

(2015) Soneela Ankam et al.   BIOMATERIALS

Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development

(2015) Hua Jia Diao et al.   BIOMATERIALS

CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

(2015) Marie E. Bechler et al.   CURRENT BIOLOGY

Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System

(2015) Schanila Nawaz et al.   DEVELOPMENTAL CELL

Engineering cell microenvironment using novel functional hydrogels

(2015) Xiaohui Zhang et al.   EUROPEAN POLYMER JOURNAL

Mechanical properties of gray and white matter brain tissue by indentation

(2015) Silvia Budday et al.   Journal of the Mechanical Behavior of Biomedical Materials

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults

(2015) Arvin Arani et al.   NEUROIMAGE

Traumatic Brain Injury and the Neuronal Microenvironment: A Potential Role for Neuropathological Mechanotransduction

(2015) Matthew A. Hemphill et al.   NEURON

3D in vitro modeling of the central nervous system

(2015) Amy M. Hopkins et al.   PROGRESS IN NEUROBIOLOGY

Extracellular environment contribution to astrogliosis—lessons learned from a tissue engineered 3D model of the glial scar

(2015) Daniela N. Rocha et al.   Frontiers in Cellular Neuroscience

Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner

(2015) Janahan Arulmoli et al.   Scientific Reports

Polypyrrole/Agarose-Based Electronically Conductive and Reversibly Restorable Hydrogel

(2014) Jaehyun Hur et al.   ACS Nano

The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system

(2014) Pouria Moshayedi et al.   BIOMATERIALS

Using biomaterials to study stem cell mechanotransduction, growth and differentiation

(2014) Rebecca J. McMurray et al.   Journal of Tissue Engineering and Regenerative Medicine

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhanced Adult Neurogenesis Increases Brain Stiffness: In Vivo Magnetic Resonance Elastography in a Mouse Model of Dopamine Depletion

(2014) Charlotte Klein et al.   PLoS One

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

(2014) Thomas Grevesse et al.   Jove-Journal of Visualized Experiments

Mechanics in Neuronal Development and Repair

(2013) Kristian Franze et al.   Annual Review of Biomedical Engineering

A rapid and reproducible assay for modeling myelination by oligodendrocytes using engineered nanofibers

(2013) Seonok Lee et al.   Nature Protocols

Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

(2013) Douglas H. Smith et al.   Nature Reviews Neurology

Probing Relevant Molecules in Modulating the Neurite Outgrowth of Hippocampal Neurons on Substrates of Different Stiffness

(2013) Wei-Hsin Chen et al.   PLoS One

Physics of adherent cells

(2013) Ulrich S. Schwarz et al.   REVIEWS OF MODERN PHYSICS

Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages

(2012) Goh Jih Her et al.   Acta Biomaterialia

Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering

(2012) Tzu-Yun Cheng et al.   BIOMATERIALS

Elasticity Maps of Living Neurons Measured by Combined Fluorescence and Atomic Force Microscopy

(2012) Elise Spedden et al.   BIOPHYSICAL JOURNAL

Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance

(2012) Vittoria Raffa et al.   International Journal of Nanomedicine

Myosin II is a negative regulator of oligodendrocyte morphological differentiation

(2012) Haibo Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanical characterization of brain tissue in compression at dynamic strain rates

(2012) Badar Rashid et al.   Journal of the Mechanical Behavior of Biomedical Materials

Magnetic resonance elastography of the brain in a mouse model of Alzheimer's disease: initial results

(2012) Matthew C. Murphy et al.   MAGNETIC RESONANCE IMAGING

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography

(2012) K. Schregel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray with Micro- and Nano-topographies Enables Identification of the Optimal Topography for Directing the Differentiation of Primary Murine Neural Progenitor Cells

(2012) Aung Aung Kywe Moe et al.   Small

Mechanical Environment Modulates Biological Properties of Oligodendrocyte Progenitor Cells

(2012) Anna Jagielska et al.   STEM CELLS AND DEVELOPMENT

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)

(2011) Lyle W. Ostrow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans

(2011) Ingolf Sack et al.   PLoS One

Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells

(2011) Albert J. Keung et al.   STEM CELLS

Control of Neural Cell Composition in Poly(Ethylene Glycol) Hydrogel Culture with Soluble Factors

(2011) Rachael Mooney et al.   TISSUE ENGINEERING PART A

Biomechanics of single cortical neurons

(2010) Kristin B. Bernick et al.   Acta Biomaterialia

The role of stiffness of gelatin–hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell

(2010) Li-Shan Wang et al.   BIOMATERIALS

The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation

(2010) Stephanie K. Seidlits et al.   BIOMATERIALS

Extracellular Matrix in Multiple Sclerosis Lesions: Fibrillar Collagens, Biglycan and Decorin are Upregulated and Associated with Infiltrating Immune Cells

(2010) Hema Mohan et al.   BRAIN PATHOLOGY

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

(2010) Yun-Bi Lu et al.   FASEB JOURNAL

Effect of macromer weight percent on neural cell growth in 2D and 3D nondegradable PEG hydrogel culture

(2010) Kyle J. Lampe et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Mechanosensitivity of astrocytes on optimized polyacrylamide gels analyzed by quantitative morphometry

(2010) Pouria Moshayedi et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Probing Cellular Traction Forces by Micropillar Arrays: Contribution of Substrate Warping to Pillar Deflection

(2010) Ingmar Schoen et al.   NANO LETTERS

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

The promotion of neuronal maturation on soft substrates

(2009) Ana I. Teixeira et al.   BIOMATERIALS

The effect of substrate stiffness on adult neural stem cell behavior

(2009) Nic D. Leipzig et al.   BIOMATERIALS

Actomyosin contractility controls cell surface area of oligodendrocytes

(2009) Angelika Kippert et al.   BMC CELL BIOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Age-Dependent Regional Mechanical Properties of the Rat Hippocampus and Cortex

(2009) Benjamin S. Elkin   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Mechanically Induced Reactive Gliosis Causes ATP-Mediated Alterations in Astrocyte Stiffness

(2009) William J. Miller et al.   JOURNAL OF NEUROTRAUMA

A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis

(2009) Emma East et al.   Journal of Tissue Engineering and Regenerative Medicine

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Myosin II has distinct functions in PNS and CNS myelin sheath formation

(2008) Haibo Wang et al.   JOURNAL OF CELL BIOLOGY

The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation

(2008) S. S. Rosenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA