Bioengineered 3D Glial Cell Culture Systems and Applications for Neurodegeneration and Neuroinflammation

A Versatile High Throughput Screening System for the Simultaneous Identification of Anti-Inflammatory and Neuroprotective Compounds

(2017) Elizabeth Hansen et al.   JOURNAL OF ALZHEIMERS DISEASE

Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration

(2016) Yuqiao Sun et al.   ACS Applied Materials & Interfaces

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

(2016) David Barata et al.   Acta Biomaterialia

Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury

(2016) W. Shi et al.   Acta Biomaterialia

3D compartmented model to study the neurite-related toxicity of Aβ aggregates included in collagen gels of adaptable porosity

(2016) Marie-Noëlle Labour et al.   Acta Biomaterialia

Drug Discovery Approaches Utilizing Three-Dimensional Cell Culture

(2016) Sarah-Louise Ryan et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

3D bioprinting for engineering complex tissues

(2016) Christian Mandrycky et al.   BIOTECHNOLOGY ADVANCES

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Targeting microglia for the treatment of Alzheimer's Disease

(2016) Paul D. Wes et al.   GLIA

Cell-Based Assay Design for High-Content Screening of Drug Candidates

(2016) Gregory Nierode et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Multitasking Microglia and Alzheimer’s Disease: Diversity, Tools and Therapeutic Targets

(2016) Alexandra Grubman et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Targeting innate immunity for neurodegenerative disorders of the central nervous system

(2016) Katrin I. Andreasson et al.   JOURNAL OF NEUROCHEMISTRY

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Stevin Zorn

(2016)   NATURE REVIEWS DRUG DISCOVERY

Astrocytes Grown in Alvetex® Three Dimensional Scaffolds Retain a Non-reactive Phenotype

(2016) Christopher I. Ugbode et al.   NEUROCHEMICAL RESEARCH

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation

(2016) Ankshita Prasad et al.   Regenerative Medicine

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development

(2016) Swarnalatha Balasubramanian et al.   TISSUE ENGINEERING PART A

Optimization of a 3D Dynamic Culturing System for In Vitro Modeling of Frontotemporal Neurodegeneration-Relevant Pathologic Features

(2016) Marta Tunesi et al.   Frontiers in Aging Neuroscience

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

(2016) Natasha Thorne et al.   Stem Cells Translational Medicine

High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform

(2016) Gregory J. Nierode et al.   Stem Cell Reports

Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain

(2016) Kun Zhou et al.   PLoS One

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

3D printing of layered brain-like structures using peptide modified gellan gum substrates

(2015) Rodrigo Lozano et al.   BIOMATERIALS

Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

(2015) Jonghoon Choi et al.   Biotechnology Journal

Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers

(2015) Joseph Grodecki et al.   BIOTECHNOLOGY PROGRESS

Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1

(2015) Brian T. Hawkins et al.   BRAIN RESEARCH

SnapShot: Genetics of Parkinson’s Disease

(2015) José Brás et al.   CELL

SnapShot: Genetics of ALS and FTD

(2015) Rita Guerreiro et al.   CELL

Isolation and characterization of primary microglia from post-natal murine brain tissues: a comparison of two methods

(2015) Shinsmon Jose et al.   CELL BIOLOGY INTERNATIONAL

Bioresorbable scaffolds in daily clinical routine

(2015) Jens Wiebe et al.   CURRENT OPINION IN CARDIOLOGY

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Regulation of astrocyte activity via control over stiffness of cellulose acetate electrospun nanofiber

(2015) Seul Ki Min et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

A review of key challenges of electrospun scaffolds for tissue-engineering applications

(2015) Sajedeh Khorshidi et al.   Journal of Tissue Engineering and Regenerative Medicine

Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease

(2015) JiSoo Park et al.   LAB ON A CHIP

Differentiation of reactive-like astrocytes cultured on nanofibrillar and comparative culture surfaces

(2015) Volkan Müjdat Tiryaki et al.   Nanomedicine

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

A Commentary on the Need for 3D-Biologically Relevant In Vitro Environments to Investigate Astrocytes and Their Role in Central Nervous System Inflammation

(2015) F. L. Maclean et al.   NEUROCHEMICAL RESEARCH

Neuronal-glial populations form functional networks in a biocompatible 3D scaffold

(2015) Imogen Smith et al.   NEUROSCIENCE LETTERS

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D in vitro modeling of the central nervous system

(2015) Amy M. Hopkins et al.   PROGRESS IN NEUROBIOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Brain region-specific gene expression profiles in freshly isolated rat microglia

(2015) Karlijn J. Doorn et al.   Frontiers in Cellular Neuroscience

Extracellular environment contribution to astrogliosis—lessons learned from a tissue engineered 3D model of the glial scar

(2015) Daniela N. Rocha et al.   Frontiers in Cellular Neuroscience

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Assessment of C-phycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model

(2015) Seul Ki Min et al.   Scientific Reports

Robust bioengineered 3D functional human intestinal epithelium

(2015) Ying Chen et al.   Scientific Reports

Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

(2015) Jonghoon Choi et al.   Biotechnology Journal

Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice

(2014) Ferdinand Ruedinger et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anti-inflammatory effects of three-dimensional graphene foams cultured with microglial cells

(2014) Qin Song et al.   BIOMATERIALS

Mechanosensing of cells in 3D gel matrices based on natural and synthetic materials

(2014) Jieling Shan et al.   CELL BIOLOGY INTERNATIONAL

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges

(2014) Sara I. Montanez-Sauri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isolation and Characterization of Microglia from Adult Mouse Brain: Selected Applications for ex Vivo Evaluation of Immunotoxicological Alterations Following in Vivo Xenobiotic Exposure

(2014) Vikas Singh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advances in 3D cell culture technologies enabling tissue-like structures to be createdin vitro

(2014) Eleanor Knight et al.   JOURNAL OF ANATOMY

3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes

(2014) Chew L. Lau et al.   JOURNAL OF NEUROCHEMISTRY

A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia

(2014) Randy Tatt Haw et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Zirconium oxide ceramic foam: a promising supporting biomaterial for massive production of glial cell line-derived neurotrophic factor

(2014) Zhong-wei Liu et al.   Journal of Zhejiang University-SCIENCE B

Multiple sclerosis genetics

(2014) Stephen Sawcer et al.   LANCET NEUROLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Genetics of Alzheimer’s Disease

(2014) Rita Guerreiro et al.   Neurotherapeutics

3-Dimensional Culture Systems for Anti-Cancer Compound Profiling and High-Throughput Screening Reveal Increases in EGFR Inhibitor-Mediated Cytotoxicity Compared to Monolayer Culture Systems

(2014) Amy L. Howes et al.   PLoS One

Bioengineered functional brain-like cortical tissue

(2014) M. D. Tang-Schomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three dimensional cellular microarray platform for human neural stem cell differentiation and toxicology

(2014) Luciana Meli et al.   Stem Cell Research

Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons

(2014) Vannary Tieng et al.   STEM CELLS AND DEVELOPMENT

Astrocyte Development and Heterogeneity

(2014) Omer Ali Bayraktar et al.   Cold Spring Harbor Perspectives in Biology

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Glioblastoma Behaviors in Three-Dimensional Collagen-Hyaluronan Composite Hydrogels

(2013) Shreyas S. Rao et al.   ACS Applied Materials & Interfaces

Culture and Differentiation of Rat Neural Stem/Progenitor Cells in a Three-Dimensional Collagen Scaffold

(2013) Dan Ge et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury

(2013) Daniel J. Macaya et al.   BIOMATERIALS

Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-l-lactic acid fibers

(2013) Jonathan M. Zuidema et al.   BIOMATERIALS

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

Bioactive 3D cell culture system minimizes cellular stress and maintains thein vivo-like morphological complexity of astroglial cells

(2013) Till B. Puschmann et al.   GLIA

Unique transcriptome signature of mouse microglia

(2013) Clara Beutner et al.   GLIA

Astrocyte behavior and GFAP expression onSpirulinaextract-incorporated PCL nanofiber

(2013) Seul Ki Min et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Implications of the oxygenated electrospun poly(ɛ-caprolactone) nanofiber for the astrocytes activities

(2013) Seul Ki Min et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

HB-EGF affects astrocyte morphology, proliferation, differentiation, and the expression of intermediate filament proteins

(2013) Till B. Puschmann et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells

(2013) Vesa Hongisto et al.   PLoS One

A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury

(2013) Emma East et al.   Regenerative Medicine

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

An aligned 3D neuronal-glial co-culture model for peripheral nerve studies

(2012) Muhammad F.B. Daud et al.   BIOMATERIALS

Discovery of Inhibitors of Microglial Neurotoxicity Acting Through Multiple Mechanisms Using a Stem-Cell-Based Phenotypic Assay

(2012) Susanne Höing et al.   Cell Stem Cell

Controlled activity of mouse astrocytes on electrospun PCL nanofiber containing polysaccharides from brown seaweed

(2012) Sang-Myung Jung et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Nanofibrillar scaffolds induce preferential activation of Rho GTPases in cerebral cortical astrocytes

(2012) Volkan Mujdat Tiryaki et al.   International Journal of Nanomedicine

The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency

(2012) Haoqing Cao et al.   MACROMOLECULAR BIOSCIENCE

Polymeric Modification and Its Implication in Drug Delivery: Poly-ε-caprolactone (PCL) as a Model Polymer

(2012) Tapan K. Dash et al.   MOLECULAR PHARMACEUTICS

Primary Cultures of Astrocytes: Their Value in Understanding Astrocytes in Health and Disease

(2012) Sofie C. Lange et al.   NEUROCHEMICAL RESEARCH

Effect of topography of an electrospun nanofiber on modulation of activity of primary rat astrocytes

(2012) Seul Ki Min et al.   NEUROSCIENCE LETTERS

Engineering an Integrated Cellular Interface in Three-Dimensional Hydrogel Cultures Permits Monitoring of Reciprocal Astrocyte and Neuronal Responses

(2012) Emma East et al.   TISSUE ENGINEERING PART C-METHODS

In vitro evaluation of the effects of electrospun PCL nanofiber mats containing the microalgae Spirulina (Arthrospira) extract on primary astrocytes

(2011) Sung Hoon Kim et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Poly-є-caprolactone based formulations for drug delivery and tissue engineering: A review

(2011) Tapan K. Dash et al.   JOURNAL OF CONTROLLED RELEASE

Poly(Vinyl Alcohol) Physical Hydrogels: New Vista on a Long Serving Biomaterial

(2011) Marie-Helene Alves et al.   MACROMOLECULAR BIOSCIENCE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

A High Throughput Screen Identifies Chemical Modulators of the Laminin-Induced Clustering of Dystroglycan and Aquaporin-4 in Primary Astrocytes

(2011) Geoffroy Noël et al.   PLoS One

Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering

(2010) Junmin Zhu   BIOMATERIALS

Cell encapsulation using biopolymer gels for regenerative medicine

(2010) Nicola C. Hunt et al.   BIOTECHNOLOGY LETTERS

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Reactive astrocytes as therapeutic targets for CNS disorders

(2010) Mary E. Hamby et al.   Neurotherapeutics

Alignment of Astrocytes Increases Neuronal Growth in Three-Dimensional Collagen Gels and Is Maintained Following Plastic Compression to Form a Spinal Cord Repair Conduit

(2010) Emma East et al.   TISSUE ENGINEERING PART A

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Heterogeneity in astrocyte morphology and physiology

(2009) Vitali Matyash et al.   BRAIN RESEARCH REVIEWS

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Rapid isolation and culture of primary microglia from adult mouse spinal cord

(2009) Ping K. Yip et al.   JOURNAL OF NEUROSCIENCE METHODS

A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis

(2009) Emma East et al.   Journal of Tissue Engineering and Regenerative Medicine

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Brain Extracellular Matrix in Neurodegeneration

(2008) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Cytocompatibility of a Novel, Longitudinally Microstructured Collagen Scaffold Intended for Nerve Tissue Repair

(2008) Sven Möllers et al.   TISSUE ENGINEERING PART A