Consideration of the Mechanical Properties of Hydrogels for Brain Tissue Engineering and Brain-on-a-chip

Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche

(2018) Christopher M. Madl et al.   Annual Review of Biomedical Engineering

Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

(2018) Junzhe Lou et al.   BIOMATERIALS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

(2017) Christopher M. Madl et al.   NATURE MATERIALS

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network

(2017) So Hyun Kim et al.   Nature Communications

Viscoelastic hydrogels for 3D cell culture

(2017) Ovijit Chaudhuri   Biomaterials Science

Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology is Dependent on Mesh Size and Storage Modulus in 3D Poly(ethylene glycol)-Based Hydrogels

(2017) Lauren N. Russell et al.   ACS Biomaterials-Science & Engineering

Oligodendrocyte Precursor Cell Viability, Proliferation, and Morphology is Dependent on Mesh Size and Storage Modulus in 3D Poly(ethylene glycol)-Based Hydrogels

(2017) Lauren N. Russell et al.   ACS Biomaterials Science & Engineering

Tuning the Range of Polyacrylamide Gel Stiffness for Mechanobiology Applications

(2016) Aleksandra K. Denisin et al.   ACS Applied Materials & Interfaces

Brain stiffness increases with myelin content

(2016) J. Weickenmeier et al.   Acta Biomaterialia

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

(2016) Sungmin Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction of Neural Cells Through Cell–Substrate Interactions

(2016) Jessica M. Stukel et al.   TISSUE ENGINEERING PART B-REVIEWS

Implantable amyloid hydrogels for promoting stem cell differentiation to neurons

(2016) Subhadeep Das et al.   NPG Asia Materials

Regional brain stiffness changes across the Alzheimer's disease spectrum

(2016) Matthew C. Murphy et al.   NeuroImage-Clinical

Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues

(2016) Tânia Lourenço et al.   Scientific Reports

Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix

(2015) Amanda L. Placone et al.   BIOMATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

3D Cell Culture Systems: Advantages and Applications

(2014) Maddaly Ravi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

A review of microfabrication and hydrogel engineering for micro-organs on chips

(2013) Marine Verhulsel et al.   BIOMATERIALS

Designing degradable hydrogels for orthogonal control of cell microenvironments

(2013) Prathamesh M. Kharkar et al.   CHEMICAL SOCIETY REVIEWS

Bioactive 3D cell culture system minimizes cellular stress and maintains thein vivo-like morphological complexity of astroglial cells

(2013) Till B. Puschmann et al.   GLIA

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Evaluation of Physical and Mechanical Properties of Porous Poly (Ethylene Glycol)-co-(L-Lactic Acid) Hydrogels during Degradation

(2013) Yu-Chieh Chiu et al.   PLoS One

Synthetic hydrogel platform for three-dimensional culture of embryonic stem cell-derived motor neurons

(2013) Daniel D. McKinnon et al.   Biomaterials Science

Differential Gene Expression in Glioblastoma Defined by ADC Histogram Analysis: Relationship to Extracellular Matrix Molecules and Survival

(2012) W.B. Pope et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Patterning Methods for Polymers in Cell and Tissue Engineering

(2012) Hong Nam Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons

(2012) Daniel Koch et al.   BIOPHYSICAL JOURNAL

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

(2012) Albert J. Keung et al.   Integrative Biology

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Viscoelastic Properties of Isolated Collagen Fibrils

(2011) Zhilei Liu Shen et al.   BIOPHYSICAL JOURNAL

Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography

(2011) Matthew C. Murphy et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers

(2011) Brian A. Aguado et al.   TISSUE ENGINEERING PART A

Cortical Neuron Outgrowth is Insensitive to Substrate Stiffness

(2010) Leann L. Norman et al.   Cellular and Molecular Bioengineering

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture

(2009) Li-Shan Wang et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis

(2009) Emma East et al.   Journal of Tissue Engineering and Regenerative Medicine

The impact of aging and gender on brain viscoelasticity

(2009) Ingolf Sack et al.   NEUROIMAGE

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING