Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

Fecal Microbiota Transplantation

(2021) Sanchit Gupta et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Evidence for gastrointestinal infection of SARS-CoV-2

(2020) Fei Xiao et al.   GASTROENTEROLOGY

Aluminum and Amyloid-β in Familial Alzheimer’s Disease

(2020) Matthew Mold et al.   JOURNAL OF ALZHEIMERS DISEASE

Murine Gut Microbiome Association With APOE Alleles

(2020) Ishita J. Parikh et al.   Frontiers in Immunology

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

(2020) Ygor Parladore Silva et al.   Frontiers in Endocrinology

Risk factor for Alzheimer’s disease breaks the blood–brain barrier

(2020) Makoto Ishii et al.   NATURE

Neuroimmune Connections in Aging and Neurodegenerative Diseases

(2020) Hannah Scheiblich et al.   TRENDS IN IMMUNOLOGY

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

(2020) Ping-Chieh Pao et al.   Nature Communications

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

The gut microbiota confers protection in the CNS against neurodegeneration induced by manganism

(2020) Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Intra‐gastrointestinal amyloid‐β1–42 oligomers perturb enteric function and induce Alzheimer's disease pathology

(2020) Yayi Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Characterizing dysbiosis of gut microbiome in PD: evidence for overabundance of opportunistic pathogens

(2020) Zachary D. Wallen et al.   npj Parkinsons Disease

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

(2020) Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Fecal microbiota transplantation therapy for Parkinson's disease

(2020) Liu-Jun Xue et al.   MEDICINE

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

(2020) Agostino Di Ciaula et al.   Genes

Genetic variants of TAS2R38 bitter taste receptor associate with distinct gut microbiota traits in Parkinson's disease: A pilot study

(2020) Sarah Vascellari et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Pro - and anti-inflammatory cytokines in the CSF of Alzheimer´s disease patients and their correlation with cognitive decline

(2019) R. Taipa et al.   NEUROBIOLOGY OF AGING

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells

(2019) Souvarish Sarkar et al.   Science Signaling

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

(2019) Peng Zheng et al.   Science Advances

The Role of Nutrition for the Aging Population: Implications for Cognition and Alzheimer's Disease

(2019) Rebecca Power et al.   Annual Review of Food Science and Technology

Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein

(2019) Dilshan S. Harischandra et al.   Science Signaling

GPR31-dependent dendrite protrusion of intestinal CX3CR1+ cells by bacterial metabolites

(2019) Naoki Morita et al.   NATURE

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

(2019) David R Beers et al.   LANCET NEUROLOGY

LRRK2 links genetic and sporadic Parkinson's disease

(2019) Jillian H. Kluss et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology

(2019) Tam T. T. Tran et al.   FASEB JOURNAL

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players

(2019) Edward B. Lee et al.   ACTA NEUROPATHOLOGICA

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer’s disease

(2019) Yusuke Fujii et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

(2019) Gil Sharon et al.   CELL

Fecal microbiota transplantation to treat Parkinsonʼs disease with constipation

(2019) Hongli Huang et al.   MEDICINE

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

(2019) Caitríona Long-Smith et al.   Annual Review of Pharmacology and Toxicology

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

(2019) Min-Soo Kim et al.   GUT

The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

(2019) Jessica R Allegretti et al.   LANCET

The role of zinc, copper, manganese and iron in neurodegenerative diseases

(2019) Leda Mezzaroba et al.   NEUROTOXICOLOGY

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice

(2019) Laia Guardia-Escote et al.   FOOD AND CHEMICAL TOXICOLOGY

The gut microbiome in neurological disorders

(2019) John F Cryan et al.   LANCET NEUROLOGY

Effect of nutrition on neurodegenerative diseases. A systematic review

(2019) Vittorio Emanuele Bianchi et al.   NUTRITIONAL NEUROSCIENCE

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

(2019) Carolina Gubert et al.   NEUROBIOLOGY OF DISEASE

Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice

(2018) Gaofeng Zhan et al.   Aging-US

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

(2018) P. A. Gill et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress

(2018) Carla Garza-Lombó et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease

(2018) Sara Castro-Sánchez et al.   GLIA

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases

(2018) Venkatanaidu Karri et al.   Journal of Proteomics

Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease

(2018) Roy Lardenoije et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice

(2018) Supak Jenkitkasemwong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CX3CR1+mononuclear phagocytes control immunity to intestinal fungi

(2018) Irina Leonardi et al.   SCIENCE

Chronic exposure to low concentrations of lead induces metabolic disorder and dysbiosis of the gut microbiota in mice

(2018) Jizhou Xia et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis

(2018) Zhenning Liu et al.   TOXICOLOGY IN VITRO

Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: A multicenter experience

(2018) Yao-Wen Cheng et al.   AMERICAN JOURNAL OF TRANSPLANTATION

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota

(2018) J. Philip Karl et al.   Frontiers in Microbiology

Branched Chain Amino Acids

(2018) Michael Neinast et al.   Annual Review of Physiology

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

(2018) Jorge Sepulcre et al.   NATURE MEDICINE

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

The gut microbiome is required for full protection against acute arsenic toxicity in mouse models

(2018) Michael Coryell et al.   Nature Communications

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

(2018) Themistoklis M. Tsarouchas et al.   Nature Communications

A Review on Gut Remediation of Selected Environmental Contaminants: Possible Roles of Probiotics and Gut Microbiota

(2018) Pengya Feng et al.   Nutrients

Fecal Microbiota Transplantation

(2017) Arjun Gupta et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

(2017) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Vaccination strategies in tauopathies and synucleinopathies

(2017) Anne K. Braczynski et al.   JOURNAL OF NEUROCHEMISTRY

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults

(2017) Lisa Manderino et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Aluminium in brain tissue in familial Alzheimer’s disease

(2017) Ambreen Mirza et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

(2017) M. Kawahara et al.   Metallomics

Absence of CX3CR1 impairs the internalization of Tau by microglia

(2017) Marta Bolós et al.   Molecular Neurodegeneration

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Branched-Chain Amino Acids and Brain Metabolism

(2017) Justin E. Sperringer et al.   NEUROCHEMICAL RESEARCH

Exposure to pesticides and the associated human health effects

(2017) Ki-Hyun Kim et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice

(2017) Giada De Palma et al.   Science Translational Medicine

Editor’s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice

(2017) Eileen M. Martinez et al.   TOXICOLOGICAL SCIENCES

Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report

(2017) Zhi He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

iTRAQ-based proteomic technology revealed protein perturbations in intestinal mucosa from manganese exposure in rat models

(2017) Hui Wang et al.   RSC Advances

Novel metabolic and physiological functions of branched chain amino acids: a review

(2017) Shihai Zhang et al.   Journal of Animal Science and Biotechnology

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

(2016) Adam C. Naj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

(2016) Ema G. Rodrigues et al.   Environmental Health

Communicating systems in the body: how microbiota and microglia cooperate

(2016) Daniel Erny et al.   IMMUNOLOGY

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Adverse events in faecal microbiota transplant: a review of the literature

(2016) M. Baxter et al.   JOURNAL OF HOSPITAL INFECTION

In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain

(2016) J. Sepulcre et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

Association of host genome with intestinal microbial composition in a large healthy cohort

(2016) Williams Turpin et al.   NATURE GENETICS

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration

(2016) Aram B. Cholanians et al.   TOXICOLOGICAL SCIENCES

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

(2016) Linda S. Zhang et al.   Genome Medicine

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Yvonne S. Eisele et al.   ACTA NEUROPATHOLOGICA

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

(2015) Ji-Hee Won et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

(2015) Jochen Walter   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

(2015) Liuji Chen et al.   NEUROBIOLOGY OF AGING

Taking aim at Alzheimer's disease through the mammalian target of rapamycin

(2014) Kenneth Maiese   ANNALS OF MEDICINE

Human Genetics Shape the Gut Microbiome

(2014) Julia K. Goodrich et al.   CELL

Aberrant Autophagy and Parkinsonism: Does Correction Rescue from Disease Progression?

(2014) Abhishek Kumar Mishra et al.   MOLECULAR NEUROBIOLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Genetics of Alzheimer’s Disease

(2014) Rita Guerreiro et al.   Neurotherapeutics

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Toward the Treatment and Prevention of Alzheimer's Disease: Rational Strategies and Recent Progress

(2013) Sam Gandy et al.   Annual Review of Medicine

Environmental Toxins and Parkinson's Disease

(2013) Samuel M. Goldman   Annual Review of Pharmacology and Toxicology

Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis

(2013) R. M. Stilling et al.   GENES BRAIN AND BEHAVIOR

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Dietary galacto-oligosaccharides and calcium: effects on energy intake, fat-pad weight and satiety-related, gastrointestinal hormones in rats

(2012) Joost Overduin et al.   BRITISH JOURNAL OF NUTRITION

Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos

(2012) Wen Li et al.   JOURNAL OF APPLIED TOXICOLOGY

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

The human microbiome: at the interface of health and disease

(2012) Ilseung Cho et al.   NATURE REVIEWS GENETICS

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

(2012) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

(2012) Marcelo Farina et al.   NEUROCHEMISTRY INTERNATIONAL

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

Mild Cognitive Impairment, Dementia, and Their Subtypes in Oldest Old Women

(2011) Kristine Yaffe et al.   ARCHIVES OF NEUROLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson’s disease

(2011) Thomas Haggerty et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Neuroimmunomodulation in the Pathogenesis of Alzheimer’s Disease

(2010) Inelia Morales et al.   NEUROIMMUNOMODULATION

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

A not entirely benign procedure: progression of Parkinson’s disease

(2008) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON