Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

(2017) Hermeto Gerber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia

(2017) Ken-ichiro Tanaka et al.   Frontiers in Neuroscience

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

(2017) Hazel L. Roberts et al.   PLoS One

Effects of oral zinc administration on long-term ipsilateral and contralateral testes damage after experimental testis ischaemia-reperfusion

(2016) A. Oral et al.   ANDROLOGIA

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

(2016) K. M. Taylor et al.   BIOCHEMICAL JOURNAL

Effects of Chronic and Acute Zinc Supplementation on Myocardial Ischemia-Reperfusion Injury in Rats

(2016) Serhan Ozyıldırım et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

(2016) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination and redox properties of copper interaction with α-synuclein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Significance of synaptic Zn 2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition

(2016) Hanuna Tamano et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Alpha-synuclein: relating metals to structure, function and inhibition

(2016) J. S. McDowall et al.   Metallomics

Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model

(2016) Constantino Tomas-Sanchez et al.   Journal of Immunology Research

Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium

(2015) Tanja Dučić et al.   ACS Chemical Neuroscience

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation

(2015) Lisa Gasperini et al.   ANTIOXIDANTS & REDOX SIGNALING

Cu(II) promotes amyloid pore formation

(2015) Hangyu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prion protein functions as a ferrireductase partner for ZIP14 and DMT1

(2015) Ajai K. Tripathi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density

(2015) Manuela Mellone et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Copper(i) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

(2015) E. Atrián-Blasco et al.   Metallomics

Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia

(2015) Dai Mizuno et al.   Metallomics

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

Intranasal deferoxamine engages multiple pathways to decrease memory loss in the APP/PS1 model of amyloid accumulation

(2015) Jared M. Fine et al.   NEUROSCIENCE LETTERS

Involvement of Trace Elements in the Pathogenesis of Prion Diseases

(2014) Dai Mizuno et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cu(II) and dopamine bind to α-synuclein and cause large conformational changes

(2014) Omid Tavassoly et al.   FEBS Journal

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue

(2014) Giuseppe D. Ciccotosto et al.   Metallomics

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein

(2014) Laura Botto et al.   PLoS One

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Alpha-synuclein biology in Lewy body diseases

(2014) Woojin Scott Kim et al.   Alzheimers Research & Therapy

A Low-Molecular-Weight Ferroxidase Is Increased in the CSF of sCJD Cases: CSF Ferroxidase and Transferrin as Diagnostic Biomarkers for sCJD

(2013) Swati Haldar et al.   ANTIOXIDANTS & REDOX SIGNALING

Efficacy and Toxicity of Clioquinol Treatment and A-beta42 Inoculation in the APP/PSI Mouse Model of Alzheimer’s Disease

(2013) Yi-Hong Zhang et al.   Current Alzheimer Research

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

The role of metal ions in amyloid formation: general principles from model peptides

(2013) Bruno Alies et al.   Metallomics

d-Histidine and l-histidine attenuate zinc-induced neuronal death in GT1-7 cells

(2013) Masahiro Kawahara et al.   Metallomics

The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

(2013) Anuj K. Sharma et al.   Metallomics

Disruption of zinc homeostasis and the pathogenesis of senile dementia

(2013) Masahiro Kawahara et al.   Metallomics

β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons

(2013) Silvia Bolognin et al.   NEUROCHEMISTRY INTERNATIONAL

Function and Dysfunction of Presenilin

(2013) Jie Shen   Neurodegenerative Diseases

Physiology and Pathophysiology of Carnosine

(2013) Alexander A. Boldyrev et al.   PHYSIOLOGICAL REVIEWS

Neuronal zinc regulation and the prion protein

(2013) Nicole T. Watt et al.   Prion

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Prion Protein Expression and Functional Importance in Developmental Angiogenesis: Role in Oxidative Stress and Copper Homeostasis

(2012) Nadia Alfaidy et al.   ANTIOXIDANTS & REDOX SIGNALING

Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease

(2012) George J. Brewer   BIOFACTORS

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

(2012) Peter K. Stys et al.   JOURNAL OF PHYSIOLOGY-LONDON

Subclinical zinc deficiency impairs human brain function

(2012) Harold H. Sandstead   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Zinc diet and Alzheimer's disease: a systematic review

(2012) Martin Loef et al.   NUTRITIONAL NEUROSCIENCE

Inhibitory circuits for visual processing in thalamus

(2011) Xin Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

The profile of β-amyloid precursor protein expression of rats induced by aluminum

(2011) Xiao-Bo Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

(2011) Masahiro Kawahara et al.   Metallomics

Dynamic action of neurometals at the synapse

(2011) Haruna Tamano et al.   Metallomics

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Copper(II) Coordination to Amyloid β: Murine versus Human Peptide

(2010) Hélène Eury et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pathology, clinical features and treatments of congenital copper metabolic disorders – Focus on neurologic aspects

(2010) Hiroko Kodama et al.   BRAIN & DEVELOPMENT

Prions and manganese: A maddening beast

(2010) David R. Brown   Metallomics

Brain proteins that mind metals: a neurodegenerative perspective

(2009) David R. Brown   DALTON TRANSACTIONS

APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer’s disease

(2009) J.R. Walton et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Copper binding to chicken and human prion protein amylodogenic regions: Differences and similarities revealed by Ni2+ as a diamagnetic probe

(2009) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics

(2009) J. Sabine Becker et al.   Metallomics

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Brain iron deficiency and excess; cognitive impairment and neurodegenration with involvement of striatum and hippocampus

(2009) Moussa B. H. Youdim   NEUROTOXICITY RESEARCH

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport

(2009) Ajay Singh et al.   PLoS One

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

(2009) Gerold Schmitt-Ulms et al.   PLoS One

Manganese Enhances Prion Protein Survival in Model Soils and Increases Prion Infectivity to Cells

(2009) Paul Davies et al.   PLoS One

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Copper(II) inhibits the formation of amylin amyloid in vitro

(2007) Benjamin Ward et al.   JOURNAL OF INORGANIC BIOCHEMISTRY