Aberrant Autophagy and Parkinsonism: Does Correction Rescue from Disease Progression?
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Aberrant Autophagy and Parkinsonism: Does Correction Rescue from Disease Progression?
Authors
Keywords
Parkinson’s disease, Autophagy, Toxin-induced Parkinsonism
Journal
MOLECULAR NEUROBIOLOGY
Volume 51, Issue 3, Pages 893-908
Publisher
Springer Nature
Online
2014-05-15
DOI
10.1007/s12035-014-8744-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Entering the lysosome through a transient gate by chaperone-mediated autophagy
- (2014) Urmi Bandyopadhyay et al. Autophagy
- LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons
- (2014) Charleen T Chu et al. Autophagy
- Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein
- (2013) Fang Yang et al. ACTA PHARMACOLOGICA SINICA
- LAMP2A as a therapeutic target in Parkinson disease
- (2013) Maria Xilouri et al. Autophagy
- PINK1 is degraded through the N-end rule pathway
- (2013) Koji Yamano et al. Autophagy
- Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance
- (2013) Michaeline L. Hebron et al. Autophagy
- Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy
- (2013) Valerie Lefebvre et al. Autophagy
- The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance
- (2013) Giulia Bertolin et al. Autophagy
- The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria
- (2013) Seok Min Jin et al. Autophagy
- Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease
- (2013) Anubhuti Dixit et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease
- (2013) Gessica Sala et al. BRAIN RESEARCH
- Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration
- (2013) L D Osellame et al. BRITISH JOURNAL OF PHARMACOLOGY
- PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
- (2013) G Arena et al. CELL DEATH AND DIFFERENTIATION
- Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
- (2013) Claudia Manzoni et al. FASEB JOURNAL
- How Parkinsonian Toxins Dysregulate the Autophagy Machinery
- (2013) Ruben Dagda et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
- (2013) An-Guo Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment
- (2013) Kei Okatsu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells
- (2013) Donna Crabtree et al. JOURNAL OF NEUROCHEMISTRY
- Does Restraining Nitric Oxide Biosynthesis Rescue from Toxins-Induced Parkinsonism and Sporadic Parkinson's Disease?
- (2013) Satya Prakash Gupta et al. MOLECULAR NEUROBIOLOGY
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
- (2013) Shireen A. Sarraf et al. NATURE
- Dangerous duet: LRRK2 and α-synuclein jam at CMA
- (2013) Zhenyu Yue et al. NATURE NEUROSCIENCE
- The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
- (2013) Marija Dulovic et al. NEUROBIOLOGY OF DISEASE
- Regulation of Autophagy by LRRK2 in Caenorhabditis elegans
- (2013) Shamol Saha et al. Neurodegenerative Diseases
- A novel and functional variant within the ATG5 gene promoter in sporadic Parkinson's disease
- (2013) Dongfeng Chen et al. NEUROSCIENCE LETTERS
- Genetic analysis of the ATG7 gene promoter in sporadic Parkinson's disease
- (2013) Dongfeng Chen et al. NEUROSCIENCE LETTERS
- Genetic causes of Parkinson's disease and their links to autophagy regulation
- (2013) Ping-Yue Pan et al. PARKINSONISM & RELATED DISORDERS
- p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions
- (2013) Yoshihisa Watanabe et al. PLoS One
- Autophagic Impairment Contributes to Systemic Inflammation-Induced Dopaminergic Neuron Loss in the Midbrain
- (2013) Hui-Fen Zheng et al. PLoS One
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
- (2013) E. S. Vincow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
- (2013) Y. Chen et al. SCIENCE
- Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease
- (2013) A C Costa et al. Cell Death & Disease
- Rotenone Upregulates Alpha-Synuclein and Myocyte Enhancer Factor 2D Independently from Lysosomal Degradation Inhibition
- (2013) Gessica Sala et al. Biomed Research International
- Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies
- (2013) Darius Ebrahimi-Fakhari et al. Acta Neuropathologica Communications
- Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death
- (2012) Burton J. Mader et al. ACS Chemical Neuroscience
- Autophagy, polyphenols and healthy ageing
- (2012) Kathrin Pallauf et al. AGEING RESEARCH REVIEWS
- Autophagy in Toxicology: Cause or Consequence?
- (2012) Sten Orrenius et al. Annual Review of Pharmacology and Toxicology
- Mitophagy in cells with mtDNA mutations
- (2012) Rosa L.A. de Vries et al. Autophagy
- Lysosomal dysfunction in Parkinson disease
- (2012) Benjamin Dehay et al. Autophagy
- LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy
- (2012) Patricia Gómez-Suaga et al. Autophagy
- Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
- (2012) Jia-Hong Lu et al. Autophagy
- Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
- (2012) Erin E. Congdon et al. Autophagy
- Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
- (2012) Michael Lazarou et al. DEVELOPMENTAL CELL
- Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
- (2012) Andrew W Greene et al. EMBO REPORTS
- Modulating macroautophagy: a neuronal perspective
- (2012) Christopher W Johnson et al. Future Medicinal Chemistry
- Therapeutic Effects of Valproate Combined With Lithium Carbonate on MPTP-Induced Parkinsonism in Mice: Possible Mediation Through Enhanced Autophagy
- (2012) Xue-zhong Li et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode
- (2012) Dorothea Becker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy
- (2012) Yu Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DJ-1 Protects Dopaminergic Neurons against Rotenone-Induced Apoptosis by Enhancing ERK-Dependent Mitophagy
- (2012) H. Gao et al. JOURNAL OF MOLECULAR BIOLOGY
- Rodent Models and Contemporary Molecular Techniques: Notable Feats yet Incomplete Explanations of Parkinson’s Disease Pathogenesis
- (2012) Sharawan Yadav et al. MOLECULAR NEUROBIOLOGY
- Effect of Trehalose on PC12 Cells Overexpressing Wild-Type or A53T Mutant α-synuclein
- (2012) Dan-Mei Lan et al. NEUROCHEMICAL RESEARCH
- Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in Mice
- (2012) Kangyong Liu et al. NEUROCHEMICAL RESEARCH
- Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways
- (2012) Jonathan Wills et al. PLoS One
- mTOR: on target for novel therapeutic strategies in the nervous system
- (2012) Kenneth Maiese et al. TRENDS IN MOLECULAR MEDICINE
- Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
- (2012) D. Narendra et al. Cold Spring Harbor Perspectives in Biology
- PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis
- (2011) Matthew E. Gegg et al. Autophagy
- Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives
- (2011) Zelda H. Cheung et al. JOURNAL OF NEUROCHEMISTRY
- Melatonin as a Neuroprotective Agent in the Rodent Models of Parkinson’s Disease: Is it All Set to Irrefutable Clinical Translation?
- (2011) Naveen Kumar Singhal et al. MOLECULAR NEUROBIOLOGY
- Autophagy in immunity and inflammation
- (2011) Beth Levine et al. NATURE
- In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression
- (2011) C. Marin et al. NEUROCHEMISTRY INTERNATIONAL
- p32 regulates mitochondrial morphology and dynamics through parkin
- (2011) Y. Li et al. NEUROSCIENCE
- The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins
- (2011) P. Wang et al. NEUROSCIENCE
- Porcine circovirus type 2 explores the autophagic machinery for replication in PK-15 cells
- (2011) Binglin Zhu et al. VIRUS RESEARCH
- Dysregulation of autophagy and Parkinson’s disease: the MEF2D link
- (2010) Qian Yang et al. APOPTOSIS
- The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
- (2010) S Michiorri et al. CELL DEATH AND DIFFERENTIATION
- Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
- (2010) Matthew E. Gegg et al. HUMAN MOLECULAR GENETICS
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
- (2010) I. Irrcher et al. HUMAN MOLECULAR GENETICS
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
- (2010) Kelly Jean Thomas et al. HUMAN MOLECULAR GENETICS
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
- (2010) You-Tong Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
- (2010) Noriyuki Matsuda et al. JOURNAL OF CELL BIOLOGY
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Eaten alive: a history of macroautophagy
- (2010) Zhifen Yang et al. NATURE CELL BIOLOGY
- PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
- (2010) Sven Geisler et al. NATURE CELL BIOLOGY
- Autophagy gone awry in neurodegenerative diseases
- (2010) Esther Wong et al. NATURE NEUROSCIENCE
- Molecular and clinical prodrome of Parkinson disease: implications for treatment
- (2010) Anthony H. V. Schapira et al. Nature Reviews Neurology
- Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease
- (2010) Giuseppe Filomeni et al. NEUROBIOLOGY OF AGING
- α-synuclein aggregation reduces nigral myocyte enhancer Factor-2D in idiopathic and experimental Parkinson's disease
- (2010) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging
- (2010) Yakup Batlevi et al. NEUROBIOLOGY OF DISEASE
- Parkinson's disease involves autophagy and abnormal distribution of cathepsin L
- (2010) Lingyun Li et al. NEUROSCIENCE LETTERS
- Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
- (2010) E. Ziviani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity
- (2009) Yunlan Du et al. Autophagy
- Olomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine
- (2009) Xi-Feng Fei et al. BRAIN RESEARCH
- Mitochondrial quality control: insights on how Parkinson’s disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis
- (2009) Ruben K. Dagda et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in -Synuclein Models of Parkinson's and Lewy Body Diseases
- (2009) B. Spencer et al. JOURNAL OF NEUROSCIENCE
- Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
- (2009) Kohichi Matsunaga et al. NATURE CELL BIOLOGY
- The emerging role of autophagy in Parkinson's disease
- (2009) Zelda H Cheung et al. Molecular Brain
- To Die or Not to Die: That is the Autophagic Question
- (2008) Maria Maiuri et al. CURRENT MOLECULAR MEDICINE
- Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1
- (2008) Tomohiro Kabuta et al. HUMAN MOLECULAR GENETICS
- Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy
- (2008) Tomohiro Kabuta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More