Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting

Actinobacteria in natural products research: progress and prospects

(2021) Polpass Arul Jose et al.   MICROBIOLOGICAL RESEARCH

Desert Environments Facilitate Unique Evolution of Biosynthetic Potential in Streptomyces

(2021) Kunjukrishnan Kamalakshi Sivakala et al.   MOLECULES

BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters

(2021) Satria A Kautsar et al.   GigaScience

The Design-Build-Test-Learn cycle for metabolic engineering of Streptomycetes

(2021) Christopher M. Whitford et al.   Essays in Biochemistry

Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration

(2021) Linda Sukmarini   MOLECULES

Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle

(2020) Carlos Cortés-Albayay et al.   JOURNAL OF ORGANIC CHEMISTRY

Streptomyces sp. VN1, a producer of diverse metabolites including non-natural furan-type anticancer compound

(2020) Hue Thi Nguyen et al.   Scientific Reports

Mass spectrometry-based metabolomics approach in the isolation of bioactive natural products

(2020) Daniel P. Demarque et al.   Scientific Reports

Isolation, Genomic and Metabolomic Characterization of Streptomyces tendae VITAKN with Quorum Sensing Inhibitory Activity from Southern India

(2020) Nabila Mohammed Ishaque et al.   Microorganisms

Intra-clade metabolomic profiling of MAR4 Streptomyces from the Macaronesia Atlantic region reveals a source of anti-biofilm metabolites

(2019) Anelize Bauermeister et al.   ENVIRONMENTAL MICROBIOLOGY

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

(2019) Changli Sun et al.   ORGANIC LETTERS

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908

(2019) Takuya Hashimoto et al.   JOURNAL OF ANTIBIOTICS

Genome engineering for microbial natural product discovery

(2018) Si-Sun Choi et al.   CURRENT OPINION IN MICROBIOLOGY

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

(2018) Olga Lage et al.   Marine Drugs

Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters

(2018) Maksym Myronovskyi et al.   METABOLIC ENGINEERING

Isolation and structure determination of a new cytotoxic peptide, curacozole, from Streptomyces curacoi based on genome mining

(2018) Issara Kaweewan et al.   JOURNAL OF ANTIBIOTICS

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

(2018) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

RiPPMiner: a bioinformatics resource for deciphering chemical structures of RiPPs based on prediction of cleavage and cross-links

(2017) Priyesh Agrawal et al.   NUCLEIC ACIDS RESEARCH

Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy

(2017) Robert A. Quinn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining

(2017) Issara Kaweewan et al.   Asian Journal of Organic Chemistry

Streptomyces venezuelae TX-TL - a next generation cell-free synthetic biology tool

(2017) Simon J. Moore et al.   Biotechnology Journal

Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.

(2016) Min Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

(2016) Mingxun Wang et al.   NATURE BIOTECHNOLOGY

New Dimensions of Research on Actinomycetes: Quest for Next Generation Antibiotics

(2016) Polpass Arul Jose et al.   Frontiers in Microbiology

Functional manipulations of the tetramycin positive regulatory gene ttmRIV to enhance the production of tetramycin A and nystatin A1 in Streptomyces ahygroscopicus

(2015) Hao Cui et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression

(2015) Dong Wan Lee et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Effects of Sucrose, Phosphate, and Calcium Carbonate on the Production of Pikromycin from Streptomyces venezuelae

(2015) Jeong Sang Yi et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

(2015) Somayah S. Elsayed et al.   JOURNAL OF ORGANIC CHEMISTRY

Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate

(2015) Mostafa E. Rateb et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity

(2015) Pandiyan Rajeswari et al.   Frontiers in Microbiology

Automated Genome Mining of Ribosomal Peptide Natural Products

(2014) Hosein Mohimani et al.   ACS Chemical Biology

Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in Streptomyces venezuelae

(2014) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced production of validamycin A in Streptomyces hygroscopicus 5008 by engineering validamycin biosynthetic gene cluster

(2014) Tan-Che Zhou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System

(2014) Ryan E. Cobb et al.   ACS Synthetic Biology

Manipulation of kynurenine pathway for enhanced daptomycin production inStreptomyces roseosporus

(2013) Guojian Liao et al.   BIOTECHNOLOGY PROGRESS

MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus

(2013) Wei-Ting Liu et al.   JOURNAL OF ANTIBIOTICS

Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

(2013) Di Huang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

(2013) Haruo Ikeda et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens

(2013) Tao Zhu et al.   METABOLIC ENGINEERING

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

(2013) Daniel Zabala et al.   METABOLIC ENGINEERING

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis

(2012) Jadwiga Turło et al.   ENZYME AND MICROBIAL TECHNOLOGY

The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity

(2012) Nadine Ziemert et al.   PLoS One

SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors

(2012) Liliya Horbal et al.   AMB Express

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor

(2011) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027

(2010) Yihua Chen et al.   JOURNAL OF ANTIBIOTICS

Characterization and Manipulation of the Pathway-Specific Late Regulator AlpW Reveals Streptomyces ambofaciens as a New Producer of Kinamycins

(2010) R. Bunet et al.   JOURNAL OF BACTERIOLOGY

Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster

(2010) Jette Thykaer et al.   METABOLIC ENGINEERING