Recent Advances in Discovery of Lead Structures from Microbial Natural Products: Genomics- and Metabolomics-Guided Acceleration

Coupling Mass Spectral and Genomic Information to Improve Bacterial Natural Product Discovery Workflows

(2021) Max Crüsemann   Marine Drugs

Roles of mTOR in Diabetic Kidney Disease

(2021) Mako Yasuda-Yamahara et al.   Antioxidants

Metagenomic applications in microbial diversity, bioremediation, pollution monitoring, enzyme and drug discovery. A review

(2020) Saptashwa Datta et al.   Environmental Chemistry Letters

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Genome Mining as New Challenge in Natural Products Discovery

(2020) Luisa Albarano et al.   Marine Drugs

Total synthesis of bryostatin 3

(2020) Barry M. Trost et al.   SCIENCE

Functional genome mining reveals a novel class V lanthipeptide containing a D‐amino acid introduced by an F420H2‐dependent reductase

(2020) Meifeng Tao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mode of action of teixobactins in cellular membranes

(2020) Rhythm Shukla et al.   Nature Communications

BiG-FAM: the biosynthetic gene cluster families database

(2020) Satria A Kautsar et al.   NUCLEIC ACIDS RESEARCH

Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

(2020) Michael A. Skinnider et al.   Nature Communications

Omics-based strategies to discover novel classes of RiPP natural products

(2020) Alexander M Kloosterman et al.   CURRENT OPINION IN BIOTECHNOLOGY

Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering

(2019) Olga N. Sekurova et al.   Microbial Biotechnology

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

(2019) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

The hidden enzymology of bacterial natural product biosynthesis

(2019) Thomas A. Scott et al.   Nature Reviews Chemistry

Structure elucidation of colibactin and its DNA cross-links

(2019) Mengzhao Xue et al.   SCIENCE

Exploration and genome mining of natural products from marine Streptomyces

(2019) Zhijie Yang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate Macrolactams

(2019) Wei Liu et al.   Marine Drugs

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

MIBiG 2.0: a repository for biosynthetic gene clusters of known function

(2019) Satria A Kautsar et al.   NUCLEIC ACIDS RESEARCH

Targeting Bacterial Genomes for Natural Product Discovery

(2019) Edward Kalkreuter et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

(2018) Elizabeth I. Parkinson et al.   ACS Chemical Biology

Accessing chemical diversity from the uncultivated symbionts of small marine animals

(2018) Thomas E Smith et al.   Nature Chemical Biology

BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins

(2018) Auke J van Heel et al.   NUCLEIC ACIDS RESEARCH

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

(2018) Bradley M. Hover et al.   Nature Microbiology

Metagenomic Approaches for Understanding New Concepts in Microbial Science

(2018) Luana de Fátima Alves et al.   International Journal of Genomics

Isolation and structure determination of a new cytotoxic peptide, curacozole, from Streptomyces curacoi based on genome mining

(2018) Issara Kaweewan et al.   JOURNAL OF ANTIBIOTICS

Unlocking the potential of natural products in drug discovery

(2018) Gerard D. Wright   Microbial Biotechnology

Using natural products for drug discovery: the impact of the genomics era

(2017) Mingzi M Zhang et al.   Expert Opinion on Drug Discovery

A new genome-mining tool redefines the lasso peptide biosynthetic landscape

(2017) Jonathan I Tietz et al.   Nature Chemical Biology

In situ cultivation of previously uncultivable microorganisms using the ichip

(2017) Brittany Berdy et al.   Nature Protocols

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

RiPPMiner: a bioinformatics resource for deciphering chemical structures of RiPPs based on prediction of cleavage and cross-links

(2017) Priyesh Agrawal et al.   NUCLEIC ACIDS RESEARCH

Discovery of the leinamycin family of natural products by mining actinobacterial genomes

(2017) Guohui Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrospective analysis of natural products provides insights for future discovery trends

(2017) Cameron R. Pye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy

(2017) Robert A. Quinn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations

(2016) Ryan A. McClure et al.   ACS Chemical Biology

Integration of Molecular Networking and In-Silico MS/MS Fragmentation for Natural Products Dereplication

(2016) Pierre-Marie Allard et al.   ANALYTICAL CHEMISTRY

Natural product discovery: past, present, and future

(2016) Leonard Katz et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic

(2016) Liujie Huo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

Assembly and clustering of natural antibiotics guides target identification

(2016) Chad W Johnston et al.   Nature Chemical Biology

IMG-ABC: new features for bacterial secondary metabolism analysis and targeted biosynthetic gene cluster discovery in thousands of microbial genomes

(2016) Michalis Hadjithomas et al.   NUCLEIC ACIDS RESEARCH

Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer

(2016) Anthony W. Goering et al.   ACS Central Science

An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria

(2016) Maria Maansson et al.   mSystems

Antibiotic drug discovery

(2016) Wolfgang Wohlleben et al.   Microbial Biotechnology

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide

(2015) Natalia A. Jungmann et al.   ACS Chemical Biology

Combining Stable Isotope Labeling and Molecular Networking for Biosynthetic Pathway Characterization

(2015) Andreas Klitgaard et al.   ANALYTICAL CHEMISTRY

CASSIS and SMIPS: promoter-based prediction of secondary metabolite gene clusters in eukaryotic genomes

(2015) Thomas Wolf et al.   BIOINFORMATICS

A New Golden Age of Natural Products Drug Discovery

(2015) Ben Shen   CELL

Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase

(2015) Takayoshi Awakawa et al.   CHEMBIOCHEM

Streptocollin, a Type IV Lanthipeptide Produced byStreptomyces collinusTü 365

(2015) Dumitrita Iftime et al.   CHEMBIOCHEM

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria

(2015) Karin Kleigrewe et al.   JOURNAL OF NATURAL PRODUCTS

Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta

(2015) Matthew J. Bertin et al.   JOURNAL OF NATURAL PRODUCTS

Targeted Metagenomics: Finding Rare Tryptophan Dimer Natural Products in the Environment

(2015) Fang-Yuan Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Computational approaches to natural product discovery

(2015) Marnix H Medema et al.   Nature Chemical Biology

The colibactin warhead crosslinks DNA

(2015) Maria I. Vizcaino et al.   Nature Chemistry

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Twenty years of bacterial genome sequencing

(2015) Nicholas J. Loman et al.   NATURE REVIEWS MICROBIOLOGY

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

(2015) Kou-San Ju et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach

(2015) Chih-Chuang Liaw et al.   Scientific Reports

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Recent advances in natural product discovery

(2014) Yunzi Luo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metagenomic small molecule discovery methods

(2014) Zachary Charlop-Powers et al.   CURRENT OPINION IN MICROBIOLOGY

Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products

(2014) Daniel Krug et al.   NATURAL PRODUCT REPORTS

A roadmap for natural product discovery based on large-scale genomics and metabolomics

(2014) James R Doroghazi et al.   Nature Chemical Biology

Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes

(2014) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orbitrap Mass Spectrometry

(2013) Roman A. Zubarev et al.   ANALYTICAL CHEMISTRY

Developing new antibacterials through natural product research

(2013) Herbert A Kirst   Expert Opinion on Drug Discovery

Importance of microbial natural products and the need to revitalize their discovery

(2013) Arnold L. Demain   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Molecular Networking as a Dereplication Strategy

(2013) Jane Y. Yang et al.   JOURNAL OF NATURAL PRODUCTS

Computational mass spectrometry for small molecules

(2013) Kerstin Scheubert et al.   Journal of Cheminformatics

Current use of high-resolution mass spectrometry in the environmental sciences

(2012) F. Hernández et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

What is the future of (ultra) high performance liquid chromatography coupled to low and high resolution mass spectrometry for toxicological drug screening?

(2012) Hans H. Maurer   JOURNAL OF CHROMATOGRAPHY A

A mass spectrometry–guided genome mining approach for natural product peptidogenomics

(2011) Roland D Kersten et al.   Nature Chemical Biology

Computational mass spectrometry for metabolomics: Identification of metabolites and small molecules

(2010) Steffen Neumann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY