Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

Induction of Holomycin Production and Complex Metabolic Changes by theargRMutation in Streptomyces clavuligerus NP1

(2012) Hua Yin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

(2012) Dandan Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement

(2012) Di Huang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis

(2012) Jadwiga Turło et al.   ENZYME AND MICROBIAL TECHNOLOGY

Effect of Different Biosynthetic Precursors on the Production of Nargenicin A1 from Metabolically Engineered Nocardia sp. CS682

(2012) Dinesh Koju   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus

(2011) Di Huang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Novel Two-Component Systems Implied in Antibiotic Production in Streptomyces coelicolor

(2011) Ana Yepes et al.   PLoS One

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Silico Identification of Gene Amplification Targets for Improvement of Lycopene Production

(2010) H. S. Choi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization

(2010) Xiangcheng Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256

(2010) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster

(2010) Jette Thykaer et al.   METABOLIC ENGINEERING

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

(2010) Hong Gao et al.   Protein & Cell

Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis

(2009) Yun Xia Duan et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides

(2009) Sushila Maharjan et al.   BIOTECHNOLOGY LETTERS

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Regulation of tacrolimus production by altering primary source of carbons and amino acids

(2009) B.P. Singh et al.   LETTERS IN APPLIED MICROBIOLOGY

Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering

(2009) Mohammad A. Asadollahi et al.   METABOLIC ENGINEERING

Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

(2008) Germán Sierra-Paredes et al.   CNS Neuroscience & Therapeutics

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING