Plant-made oral vaccines against human infectious diseases-Are we there yet?

Delivery strategies to enhance oral vaccination against enteric infections

(2015) Christopher J.H. Davitt et al.   ADVANCED DRUG DELIVERY REVIEWS

Enterovirus C strains circulating in Nigeria and their contribution to the emergence of recombinant circulating vaccine-derived polioviruses

(2015) Johnson Adekunle Adeniji et al.   ARCHIVES OF VIROLOGY

Antimicrobial peptide production and plant-based expression systems for medical and agricultural biotechnology

(2015) Edita Holaskova et al.   BIOTECHNOLOGY ADVANCES

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

(2015) X. Wang et al.   BLOOD

The increasing value of plant-made proteins

(2015) Markus Sack et al.   CURRENT OPINION IN BIOTECHNOLOGY

Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects

(2015) Rafael Pires Oliveira et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Toxoplasma gondii-induced neuronal alterations

(2015) A. Parlog et al.   PARASITE IMMUNOLOGY

Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice

(2015) Hartinio N. Nahampun et al.   PLANT CELL REPORTS

Infection byToxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia

(2015) Hong-Mei Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral delivery of wafers made from HBsAg-expressing maize germ induces long-term immunological systemic and mucosal responses

(2015) Celine A. Hayden et al.   VACCINE

Extracting transmission networks from phylogeographic data for epidemic and endemic diseases: Ebola virus in Sierra Leone, 2009 H1N1 pandemic influenza and polio in Nigeria

(2015) Michael Famulare et al.   International Health

The fusion ofToxoplasma gondiiSAG1 vaccine candidate toLeishmania infantumheat shock protein 83-kDa improves expression levels in tobacco chloroplasts

(2015) Romina M. Albarracín et al.   Biotechnology Journal

Developing inexpensive malaria vaccines from plants and algae

(2014) James A. Gregory et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells

(2014) A. Sherman et al.   BLOOD

Transgenic plants: a 5-year update on oral antipathogen vaccine development

(2014) Marisela Hernández et al.   Expert Review of Vaccines

Optimizing IGF-I for skeletal muscle therapeutics

(2014) Anastassios Philippou et al.   GROWTH HORMONE & IGF RESEARCH

Oral Delivery of Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates Pulmonary Hypertension

(2014) Vinayak Shenoy et al.   HYPERTENSION

Challenges in mucosal vaccines for the control of infectious diseases

(2014) T. Azegami et al.   INTERNATIONAL IMMUNOLOGY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Vaccine-Derived Polioviruses

(2014) C. C. Burns et al.   JOURNAL OF INFECTIOUS DISEASES

Expression of Rabies Glycoprotein and Ricin Toxin B Chain (RGP–RTB) Fusion Protein in Tomato Hairy Roots: A Step Towards Oral Vaccination for Rabies

(2014) Ankit Singh et al.   MOLECULAR BIOTECHNOLOGY

Oral Delivery of ACE2/Ang-(1–7) Bioencapsulated in Plant Cells Protects against Experimental Uveitis and Autoimmune Uveoretinitis

(2014) Pollob K Shil et al.   MOLECULAR THERAPY

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Immunology ofTaenia soliumtaeniasis and human cysticercosis

(2014) H. H. Garcia et al.   PARASITE IMMUNOLOGY

Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidatePfAMA1 produced inNicotiana benthamianaand analysis of growth inhibitory responses in rabbits

(2014) Alexander Boes et al.   PLANT BIOTECHNOLOGY JOURNAL

Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants

(2014) François Le Mauff et al.   PLANT BIOTECHNOLOGY JOURNAL

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection

(2014) Goeun Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

An Outbreak of Type Π Vaccine-Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population

(2014) Hai-Bo Wang et al.   PLoS One

Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses

(2014) Ingrid Lindh et al.   VACCINE

Supercritical fluid extraction provides an enhancement to the immune response for orally-delivered hepatitis B surface antigen

(2014) Celine A. Hayden et al.   VACCINE

The mucosal immune system for vaccine development

(2014) Aayam Lamichhane et al.   VACCINE

Vaccines against human diarrheal pathogens

(2014) Nathalie Böhles et al.   Human Vaccines & Immunotherapeutics

Freeze-Drying of Plant Tissue Containing HBV Surface Antigen for the Oral Vaccine against Hepatitis B

(2014) Marcin Czyż et al.   Biomed Research International

Dengue virus tetra-epitope peptide expressed in lettuce chloroplasts for potential use in dengue diagnosis

(2013) Franciele Roberta Maldaner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Immunization with an HPV-16 L1-based chimeric virus-like particle containing HPV-16 E6 and E7 epitopes elicits long-lasting prophylactic and therapeutic efficacy in an HPV-16 tumor mice model

(2013) Alberto Monroy-García et al.   ARCHIVES OF VIROLOGY

Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses during a Large Outbreak in Northern Nigeria

(2013) C. C. Burns et al.   JOURNAL OF VIROLOGY

Oral Delivery of Bioencapsulated Proteins Across Blood–Brain and Blood–Retinal Barriers

(2013) Neha Kohli et al.   MOLECULAR THERAPY

ELPylated haemagglutinins produced in tobacco plants induce potentially neutralizing antibodies against H5N1 viruses in mice

(2013) Hoang T. Phan et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant species and organ influence the structure and subcellular localization of recombinant glycoproteins

(2013) Elsa Arcalis et al.   PLANT MOLECULAR BIOLOGY

Immunogenic properties of a lettuce-derived C4(V3)6 multiepitopic HIV protein

(2013) Dania O. Govea-Alonso et al.   PLANTA

Low Cost Tuberculosis Vaccine Antigens in Capsules: Expression in Chloroplasts, Bio-Encapsulation, Stability and Functional Evaluation In Vitro

(2013) Priya Saikumar Lakshmi et al.   PLoS One

A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized Mice

(2013) R. Mark Jones et al.   PLoS One

Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults

(2013) James F. Cummings et al.   VACCINE

Oral Immunogenicity of Plant-MadeMycobacterium tuberculosisESAT6 and CFP10

(2013) Elena A. Uvarova et al.   Biomed Research International

Mechanism of oral tolerance induction to therapeutic proteins

(2012) Xiaomei Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

Using storage organelles for the accumulation and encapsulation of recombinant proteins

(2012) Imran Khan et al.   Biotechnology Journal

Glycan-Dependent Immunogenicity of Recombinant Soluble Trimeric Hemagglutinin

(2012) R. P. de Vries et al.   JOURNAL OF VIROLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells

(2012) Stephanie C. Eisenbarth et al.   NATURE

Production of highly concentrated, heat-stable hepatitis B surface antigen in maize

(2012) Celine A. Hayden et al.   PLANT BIOTECHNOLOGY JOURNAL

A chloroplast-derivedToxoplasma gondiiGRA4 antigen used as an oral vaccine protects against toxoplasmosis in mice

(2012) María del L. Yácono et al.   PLANT BIOTECHNOLOGY JOURNAL

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells

(2012) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

The use of plants for the production of therapeutic human peptides

(2012) Chiara Lico et al.   PLANT CELL REPORTS

Design of chimeric expression elements that confer high-level gene activity in chromoplasts

(2012) Rodrigo Caroca et al.   PLANT JOURNAL

A chloroplast-derived C4V3 polypeptide from the human immunodeficiency virus (HIV) is orally immunogenic in mice

(2012) Néstor Rubio-Infante et al.   PLANT MOLECULAR BIOLOGY

E-Peptides Control Bioavailability of IGF-1

(2012) Marianne Smedegaard Hede et al.   PLoS One

Induction of a protective immune response to rabies virus in sheep after oral immunization with transgenic maize, expressing the rabies virus glycoprotein

(2012) Elizabeth Loza-Rubio et al.   VACCINE

Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen

(2012) Celine A. Hayden et al.   VACCINE

Plant-derived vaccines

(2012) Mohammad Tahir Waheed et al.   Human Vaccines & Immunotherapeutics

Transgenic tobacco expressed HPV16-L1 and LT-B combined immunization induces strong mucosal and systemic immune responses in mice

(2012) Liu Hongli et al.   Human Vaccines & Immunotherapeutics

Production of foreign proteins using plastid transformation

(2011) Nunzia Scotti et al.   BIOTECHNOLOGY ADVANCES

Role of transgenic plants in agriculture and biopharming

(2011) Parvaiz Ahmad et al.   BIOTECHNOLOGY ADVANCES

Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza

(2011) Yoko Shoji et al.   Human vaccines & immunotherapeutics

Transgenic crops for the production of recombinant vaccines and anti-microbial antibodies

(2011) Jenny Peters et al.   Human vaccines & immunotherapeutics

Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond

(2011) Vidadi Yusibov et al.   Human vaccines & immunotherapeutics

Murine immune responses to a Plasmodium vivax-derived chimeric recombinant protein expressed in Brassica napus

(2011) Choonghee Lee et al.   MALARIA JOURNAL

Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts

(2011) Shashi Kumar et al.   METABOLIC ENGINEERING

Tobacco plastidial thioredoxins as modulators of recombinant protein production in transgenic chloroplasts

(2011) Ruth Sanz-Barrio et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity of chloroplast-derived HIV-1 p24 and a p24-Nef fusion protein following subcutaneous and oral administration in mice

(2011) Nuria Gonzalez-Rabade et al.   PLANT BIOTECHNOLOGY JOURNAL

Plastid expression of a double-pentameric vaccine candidate containing human papillomavirus-16 L1 antigen fused with LTB as adjuvant: transplastomic plants show pleiotropic phenotypes

(2011) Mohammad T. Waheed et al.   PLANT BIOTECHNOLOGY JOURNAL

Current status and perspectives of plant-based candidate vaccines against the human immunodeficiency virus (HIV)

(2011) Sergio Rosales-Mendoza et al.   PLANT CELL REPORTS

Expression of the cholera toxin B subunit (CT-B) in maize seeds and a combined mucosal treatment against cholera and traveler’s diarrhea

(2011) S. Karaman et al.   PLANT CELL REPORTS

Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants

(2011) Sergio Rosales-Mendoza et al.   PLANT CELL REPORTS

Plastid biotechnology for crop production: present status and future perspectives

(2011) Jihong Liu Clarke et al.   PLANT MOLECULAR BIOLOGY

Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts

(2011) Anderson Paul Kanagaraj et al.   PLANT MOLECULAR BIOLOGY

Overproduction of recombinant proteins in plants

(2011) Erin Egelkrout et al.   PLANT SCIENCE

Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs

(2011) Min-Yuan Chia et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

(2011) Eric C. Martens et al.   PLOS BIOLOGY

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Antibody Responses in Mice Stimulated by Various Doses of the Potato-Derived Major Surface Antigen of Hepatitis B Virus

(2010) J. W. Youm et al.   Clinical and Vaccine Immunology

Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD− S. Typhi-specific IgA and IgG B memory cells in humans

(2010) Rezwanul Wahid et al.   CLINICAL IMMUNOLOGY

Plant-based anti-HIV-1 strategies: vaccine molecules and antiviral approaches

(2010) Nunzia Scotti et al.   Expert Review of Vaccines

Immunology of gut mucosal vaccines

(2010) Marcela F. Pasetti et al.   IMMUNOLOGICAL REVIEWS

Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation

(2010) Tomasz Pniewski et al.   JOURNAL OF APPLIED GENETICS

Expression and Immunogenicity of the Mycobacterial Ag85B/ESAT-6 Antigens Produced in Transgenic Plants by Elastin-Like Peptide Fusion Strategy

(2010) Doreen Manuela Floss et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Topical immunization strategies

(2010) C Czerkinsky et al.   Mucosal Immunology

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Secretory IgA-mediated protection against V. cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine

(2010) D. Tokuhara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transplastomic expression of a modified human papillomavirus L1 protein leading to the assembly of capsomeres in tobacco: a step towards cost-effective second-generation vaccines

(2010) M. Tahir Waheed et al.   TRANSGENIC RESEARCH

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

(2010) Ali Azizi et al.   PLoS Pathogens

Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

(2009) Reynald Tremblay et al.   BIOTECHNOLOGY ADVANCES

Mucosal vaccines: novel advances in technology and delivery

(2009) Yoshikazu Yuki et al.   Expert Review of Vaccines

Oral transgenic plant-based vaccine for hepatitis B

(2009) Yasmin Thanavala et al.   IMMUNOLOGIC RESEARCH

Expression and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile Toxin B Subunit in Transgenic Rice Callus

(2009) Tae-Geum Kim et al.   MOLECULAR BIOTECHNOLOGY

Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery

(2009) Abdoreza Davoodi-Semiromi et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

(2008) Harry J. Flint et al.   NATURE REVIEWS MICROBIOLOGY

Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic

(2008) Alicia Fernández-San Millán et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration

(2008) Denise Guetard et al.   VACCINE