Plant-produced candidate countermeasures against emerging and reemerging infections and bioterror agents

Plant-Derived Recombinant Fl, V, and F1-V Fusion Antigens of Yersinia Pestis Activate Human Cells of the Innate and Adaptive Immune System

(2017) G. Del Prete et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

(2015) Qiang Chen   Biotechnology Journal

Novel vaccination approach for dengue infection based on recombinant immune complex universal platform

(2015) Mi-Young Kim et al.   VACCINE

Plant-made vaccines against West Nile virus are potent, safe, and economically feasible

(2015) Qiang Chen   Biotechnology Journal

Potential and Emerging Treatment Options for Ebola Virus Disease

(2014) Bryan M. Bishop   ANNALS OF PHARMACOTHERAPY

Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases

(2014) Eva Stoger et al.   Annual Review of Plant Biology

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Advances and challenges in the development and production of effective plant-based influenza vaccines

(2014) Vidadi Yusibov et al.   Expert Review of Vaccines

Generation of protective immune response against anthrax by oral immunization with protective antigen plant-based vaccine

(2014) Jyotsna Gorantala et al.   JOURNAL OF BIOTECHNOLOGY

Sanofi's dengue vaccine first to complete phase 3

(2014) Gunjan Sinha   NATURE BIOTECHNOLOGY

Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward Projections

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Care of Two Patients with Ebola Virus Disease in the United States

(2014) G. Marshall Lyon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ebola 2014 — New Challenges, New Global Response and Responsibility

(2014) Thomas R. Frieden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

(2014) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Generation and Analysis of Novel Plant-Derived Antibody-Based Therapeutic Molecules against West Nile Virus

(2014) Junyun He et al.   PLoS One

Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines

(2014) Brian J. Ward et al.   VACCINE

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

US signs contract with ZMapp maker to accelerate development of the Ebola drug

(2014) M. McCarthy   BMJ-British Medical Journal

Immunogenicity of H1N1 influenza virus-like particles produced inNicotiana benthamiana

(2014) Yoko Shoji et al.   Human Vaccines & Immunotherapeutics

A Plant-Produced Antigen Elicits Potent Immune Responses against West Nile Virus in Mice

(2014) Junyun He et al.   Biomed Research International

Hybrid Viral Vectors for Vaccine and Antibody Production in Plants

(2013) Vidadi Yusibov et al.   CURRENT PHARMACEUTICAL DESIGN

N-Glycosylation of Plant-produced Recombinant Proteins

(2013) Dirk Bosch et al.   CURRENT PHARMACEUTICAL DESIGN

Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail

(2013) J. Pettitt et al.   Science Translational Medicine

Medical aspects of bio-terrorism

(2013) Mahdi Balali-Mood et al.   TOXICON

Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults

(2013) James F. Cummings et al.   VACCINE

A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge

(2013) Yoko Shoji et al.   Human Vaccines & Immunotherapeutics

A plant-produced protective antigen vaccine confers protection in rabbits against a lethal aerosolized challenge withBacillus anthracisAmes spores

(2013) Jessica A. Chichester et al.   Human Vaccines & Immunotherapeutics

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

(2012) Hassan Z. A. Ishag et al.   ARCHIVES OF VIROLOGY

M Cell-Targeting Ligand and Consensus Dengue Virus Envelope Protein Domain III Fusion Protein Production in Transgenic Rice Calli

(2012) Tae-Geum Kim et al.   MOLECULAR BIOTECHNOLOGY

Production of non-glycosylated recombinant proteins inNicotiana benthamianaplants by co-expressing bacterial PNGase F

(2012) Tarlan Mamedov et al.   PLANT BIOTECHNOLOGY JOURNAL

The use of plants for the production of therapeutic human peptides

(2012) Chiara Lico et al.   PLANT CELL REPORTS

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

(2012) G. G. Olinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful Treatment of Ebola Virus-Infected Cynomolgus Macaques with Monoclonal Antibodies

(2012) X. Qiu et al.   Science Translational Medicine

RNAi suppression of rice endogenous storage proteins enhances the production of rice-based Botulinum neutrotoxin type A vaccine

(2012) Yoshikazu Yuki et al.   VACCINE

Safety and Immunogenicity of a Plant-Produced Recombinant Hemagglutinin-Based Influenza Vaccine (HAI-05) Derived from A/Indonesia/05/2005 (H5N1) Influenza Virus: A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study in Healthy Adults

(2012) Jessica Chichester et al.   Viruses-Basel

Virus-like particle (VLP)-based vaccines for pandemic influenza

(2012) Constantino López-Macías   Human Vaccines & Immunotherapeutics

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

Structural basis of influenza virus neutralization

(2011) Thomas Han et al.   Annals of the New York Academy of Sciences

Post-translational modification of plant-made foreign proteins; glycosylation and beyond

(2011) Diane E. Webster et al.   BIOTECHNOLOGY ADVANCES

Production of recombinant proteins by yeast cells

(2011) Eda Çelik et al.   BIOTECHNOLOGY ADVANCES

Insect cells as factories for biomanufacturing

(2011) Jean-Christophe Drugmand et al.   BIOTECHNOLOGY ADVANCES

Mammalian cell protein expression for biopharmaceutical production

(2011) Jianwei Zhu   BIOTECHNOLOGY ADVANCES

Green factory: Plants as bioproduction platforms for recombinant proteins

(2011) Jianfeng Xu et al.   BIOTECHNOLOGY ADVANCES

Bacterial expression systems for recombinant protein production: E. coli and beyond

(2011) Rachel Chen   BIOTECHNOLOGY ADVANCES

Efficient production of chimeric Human papillomavirus 16 L1 protein bearing the M2e influenza epitope in Nicotiana benthamiana plants

(2011) Slavica Matić et al.   BMC BIOTECHNOLOGY

Mice Orally Immunized with a Transgenic Plant Expressing the Glycoprotein of Crimean-Congo Hemorrhagic Fever Virus

(2011) S. M. Ghiasi et al.   Clinical and Vaccine Immunology

Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies

(2011) Xiangguo Qiu et al.   CLINICAL IMMUNOLOGY

Vaccination and Antiviral Treatment of Neglected Diseases Caused by Flaviviral Infections

(2011) K. Schleich et al.   CURRENT MEDICINAL CHEMISTRY

A non-glycosylated, plant-produced human monoclonal antibody against anthrax protective antigen protects mice and non-human primates fromB. anthracisspore challenge

(2011) Vadim Mett et al.   Human vaccines & immunotherapeutics

Argentine hemorrhagic fever vaccines

(2011) Ana Ambrosio et al.   Human vaccines & immunotherapeutics

Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza

(2011) Yoko Shoji et al.   Human vaccines & immunotherapeutics

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

(2011) Qiang Chen et al.   Human vaccines & immunotherapeutics

Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond

(2011) Vidadi Yusibov et al.   Human vaccines & immunotherapeutics

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

(2011) Waranyoo Phoolcharoen et al.   PLANT BIOTECHNOLOGY JOURNAL

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

(2011) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of dengue-3 premembrane and envelope polyprotein in lettuce chloroplasts

(2011) Anderson Paul Kanagaraj et al.   PLANT MOLECULAR BIOLOGY

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

(2011) L. Zeitlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax

(2011) Jyotsna Gorantala et al.   VACCINE

From research to phase III: Preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine

(2011) Bruno Guy et al.   VACCINE

Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit

(2011) Joanne M. O’Hara et al.   VACCINE

Yeast expressed recombinant Hemagglutinin protein of Novel H1N1 elicits neutralising antibodies in rabbits and mice

(2011) TN Athmaram et al.   Virology Journal

Flavivirus Cell Entry and Membrane Fusion

(2011) Jolanda Smit et al.   Viruses-Basel

Expression of dengue virus E glycoprotein domain III in non-nicotine transgenic tobacco plants

(2010) Mi-Young Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Exploring different strategies to express Dengue virus envelope protein in a plant system

(2010) Carolina Andrea Martínez et al.   BIOTECHNOLOGY LETTERS

Transgenic carrot tap roots expressing an immunogenic F1–V fusion protein from Yersinia pestis are immunogenic in mice

(2010) Sergio Rosales-Mendoza et al.   JOURNAL OF PLANT PHYSIOLOGY

Human IgG Subclasses: In Vitro Neutralization of and In Vivo Protection against West Nile Virus

(2010) Y. Hofmeister et al.   JOURNAL OF VIROLOGY

Molecular mechanisms involved in the early steps of flavivirus cell entry

(2010) Bärbel Kaufmann et al.   MICROBES AND INFECTION

Plant-made vaccines for humans and animals

(2010) Edward P. Rybicki   PLANT BIOTECHNOLOGY JOURNAL

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of an immunogenic F1-V fusion protein in lettuce as a plant-based vaccine against plague

(2010) Sergio Rosales-Mendoza et al.   PLANTA

Mammalian Expression of Virus-Like Particles for Advanced Mimicry of Authentic Influenza Virus

(2010) Chia-Ying Wu et al.   PLoS One

HIV-1 Neutralization Profile and Plant-Based Recombinant Expression of Actinohivin, an Env Glycan-Specific Lectin Devoid of T-Cell Mitogenic Activity

(2010) Nobuyuki Matoba et al.   PLoS One

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Monoclonal antibody produced in plants efficiently treats West Nile virus infection in mice

(2010) H. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholera toxin B subunit-domain III of dengue virus envelope glycoprotein E fusion protein production in transgenic plants

(2010) Tae-Geum Kim et al.   PROTEIN EXPRESSION AND PURIFICATION

Adverse event reports following Japanese encephalitis vaccination in the United States, 1999–2009

(2010) Nicole P. Lindsey et al.   VACCINE

A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge

(2010) George W. Buchman et al.   VACCINE

Generation and immunogenicity of Japanese encephalitis virus envelope protein expressed in transgenic rice

(2009) Yuanyuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plants as bioreactors for the production of vaccine antigens

(2009) Siddharth Tiwari et al.   BIOTECHNOLOGY ADVANCES

Prevention of bubonic and pneumonic plague using plant-derived vaccines

(2009) M. Lucrecia Alvarez et al.   BIOTECHNOLOGY ADVANCES

Using plant cells as influenza vaccine substrates

(2009) Jessica A Chichester et al.   Expert Review of Vaccines

A Monoclonal Immunoglobulin G Antibody Directed against an Immunodominant Linear Epitope on the Ricin A Chain Confers Systemic and Mucosal Immunity to Ricin

(2009) L. M. Neal et al.   INFECTION AND IMMUNITY

Expression of Japanese encephalitis virus envelope protein in transgenic tobacco plants

(2009) Mohan Babu Appaiahgari et al.   JOURNAL OF VIROLOGICAL METHODS

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Heavily Isotype-Dependent Protective Activities of Human Antibodies against Vaccinia Virus Extracellular Virion Antigen B5

(2009) M. R.-E.-I. Benhnia et al.   JOURNAL OF VIROLOGY

Cowpea mosaic virus chimeric particles bearing the ectodomain of matrix protein 2 (M2E) of the influenza a virus: Production and characterization

(2009) Yu. A. Meshcheryakova et al.   MOLECULAR BIOLOGY

Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus

(2009) Kathy Hancock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transgenic chloroplasts are efficient sites for high-yield production of the vaccinia virus envelope protein A27L in plant cells

(2009) M. Manuela Rigano et al.   PLANT BIOTECHNOLOGY JOURNAL

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

Plants as biofactories for the production of subunit vaccines against bio-security-related bacteria and viruses☆

(2009) M. Manuela Rigano et al.   VACCINE

Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice

(2009) Nuoyan Zheng et al.   VACCINE

A single component two-valent LcrV-F1 vaccine protects non-human primates against pneumonic plague

(2009) Jessica A. Chichester et al.   VACCINE

Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity

(2009) Yoshikazu Yuki et al.   VACCINE

Plant-produced potato virus X chimeric particles displaying an influenza virus-derived peptide activate specific CD8+ T cells in mice

(2009) Chiara Lico et al.   VACCINE

Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development

(2008) Theodore C. Pierson et al.   Cell Host & Microbe

Plant Molecular Farming: Opportunities and Challenges

(2008) Pervin Basaran et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Molecular mechanisms of antibody-mediated neutralisation of flavivirus infection

(2008) Theodore C. Pierson et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Plant-produced Hepatitis B Core Protein Chimera Carrying Anthrax Protective Antigen Domain-4

(2008) Katarzyna Bandurska et al.   HYBRIDOMA

Effective Plague Vaccination via Oral Delivery of Plant Cells Expressing F1-V Antigens in Chloroplasts

(2008) P. A. Arlen et al.   INFECTION AND IMMUNITY

A plant-produced influenza subunit vaccine protects ferrets against virus challenge

(2008) Vadim Mett et al.   Influenza and Other Respiratory Viruses

Global trends in emerging infectious diseases

(2008) Kate E. Jones et al.   NATURE

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

P19-dependent and P19-independent reversion of F1-V gene silencing in tomato

(2008) M. Lucrecia Alvarez et al.   PLANT MOLECULAR BIOLOGY

Immunogenic properties of plant-derived recombinant smallpox vaccine candidate pB5

(2008) Carla Portocarrero et al.   VACCINE

Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza

(2008) Yoko Shoji et al.   VACCINE