Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana

Molecular farming – The slope of enlightenment

(2020) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

(2020) Xiaolong Tian et al.   Emerging Microbes & Infections

Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development

(2020) Balamurugan Shanmugaraj et al.   Pathogens

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

(2020) Meng Yuan et al.   SCIENCE

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Emerging Zoonotic Respiratory Pathogen in Humans

(2020) Ashwini Malla et al.   JOURNAL OF PURE AND APPLIED MICROBIOLOGY

Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

(2020) Balamurugan Shanmugaraj et al.   Plants-Basel

Modifying the Replication of Geminiviral Vectors Reduces Cell Death and Enhances Expression of Biopharmaceutical Proteins in Nicotiana benthamiana Leaves

(2019) Andrew G. Diamos et al.   Frontiers in Plant Science

In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants

(2019) Jonathan Hurtado et al.   PLANT BIOTECHNOLOGY JOURNAL

Improving plant transient expression through the rational design of synthetic 5′ and 3′ untranslated regions

(2019) Hadrien Peyret et al.   Plant Methods

Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins

(2019) Stefan Schillberg et al.   Frontiers in Plant Science

Structural and In Vitro Functional Analyses of Novel Plant-Produced Anti-Human PD1 Antibody

(2019) Kaewta Rattanapisit et al.   Scientific Reports

Plant-Produced Anti-Enterovirus 71 (EV71) Monoclonal Antibody Efficiently Protects Mice Against EV71 Infection

(2019) Kaewta Rattanapisit et al.   Plants-Basel

Recombinant Human Dentin Matrix Protein 1 (hDMP1) Expressed in Nicotiana benthamiana Potentially Induces Osteogenic Differentiation

(2019) Aktsar Roskiana Ahmad et al.   Plants-Basel

Plant-made polio type 3 stabilized VLPs—a candidate synthetic polio vaccine

(2017) Johanna Marsian et al.   Nature Communications

Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus

(2017) Anna Bootz et al.   PLoS Pathogens

A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus

(2017) Sergio Rosales-Mendoza et al.   Frontiers in Immunology

Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells

(2017) Kaewta Rattanapisit et al.   Scientific Reports

Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity

(2016) Matthew Dent et al.   JOURNAL OF GENERAL VIROLOGY

Cold chain and virus-free chloroplast-made booster vaccine to confer immunity against different poliovirus serotypes

(2016) Hui-Ting Chan et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant-produced biopharmaceuticals: A case of technical developments driving clinical deployment

(2016) G. P. Lomonossoff et al.   SCIENCE

Plant-produced candidate countermeasures against emerging and reemerging infections and bioterror agents

(2015) Stephen J. Streatfield et al.   PLANT BIOTECHNOLOGY JOURNAL

Transient expressions of synthetic biology in plants

(2014) Frank Sainsbury et al.   CURRENT OPINION IN PLANT BIOLOGY

Engineering, Expression in Transgenic Plants and Characterisation of E559, a Rabies Virus-Neutralising Monoclonal Antibody

(2014) Craig J. van Dolleweerd et al.   JOURNAL OF INFECTIOUS DISEASES

Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants

(2014) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco

(2013) Audrey Y-H. Teh et al.   PLANT BIOTECHNOLOGY JOURNAL

Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly Neutralizing

(2012) Hatem A. Elshabrawy et al.   PLoS One

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants

(2011) Qiang Chen et al.   Human vaccines & immunotherapeutics

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

(2011) Waranyoo Phoolcharoen et al.   PLANT BIOTECHNOLOGY JOURNAL

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

(2011) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

(2010) Zhong Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Transient expression systems for plant-derived biopharmaceuticals

(2010) Tatiana V Komarova et al.   Expert Review of Vaccines

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs