Plant-Expressed Receptor Binding Domain of the SARS-CoV-2 Spike Protein Elicits Humoral Immunity in Mice

Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment

(2021) Olivier J Wouters et al.   LANCET

Intranasal Administration of a Recombinant RBD Vaccine Induced Protective Immunity Against SARS-CoV-2 in Mouse

(2021) Yingying Du et al.   VACCINE

Recombinant vaccine containing an RBD-Fc fusion induced protection against SARS-CoV-2 in nonhuman primates and mice

(2021) Shihui Sun et al.   Cellular & Molecular Immunology

SARS-CoV-2 Antigens Expressed in Plants Detect Antibody Responses in COVID-19 Patients

(2021) Mohau S. Makatsa et al.   Frontiers in Plant Science

Molecular farming – The slope of enlightenment

(2020) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Host protein glycosylation in nucleic acid vaccines as a potential hurdle in vaccine design for nonviral pathogens

(2020) Ahmet Ozdilek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection

(2020) Leroy Versteeg et al.   PLoS Neglected Tropical Diseases

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

(2020) Sin Fun Sia et al.   NATURE

Site-specific glycan analysis of the SARS-CoV-2 spike

(2020) Yasunori Watanabe et al.   SCIENCE

Potential Applications of Plant Biotechnology against SARS-CoV-2

(2020) Teresa Capell et al.   TRENDS IN PLANT SCIENCE

A human monoclonal antibody blocking SARS-CoV-2 infection

(2020) Chunyan Wang et al.   Nature Communications

What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?

(2020) Sergio Rosales-Mendoza et al.   Vaccines

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

(2020) Jingyun Yang et al.   NATURE

The imbalance of Th1/Th2 triggers an inflammatory response in chicken spleens after ammonia exposure

(2020) Fuqing Zhao et al.   POULTRY SCIENCE

From Farm to Finger Prick—A Perspective on How Plants Can Help in the Fight Against COVID-19

(2020) Karen A. McDonald et al.   Frontiers in Bioengineering and Biotechnology

Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach

(2020) Ahmad Abu Turab Naqvi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials

(2020) Brian J Ward et al.   LANCET

Potential use of noncoding RNAs and innovative therapeutic strategies to target the 5’UTR of SARS-CoV-2

(2020) Antonella Baldassarre et al.   Epigenomics

Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana

(2020) Kaewta Rattanapisit et al.   Scientific Reports

Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

(2020) Oliver C. Grant et al.   Scientific Reports

Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein

(2020) René Wintjens et al.   npj Vaccines

Plant-Based Vaccines: The Way Ahead?

(2020) Zacharie LeBlanc et al.   Viruses-Basel

Plant-based vaccines and antibodies to combat COVID-19: current status and prospects

(2020) Kuldeep Dhama et al.   Human Vaccines & Immunotherapeutics

SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

(2020) Mei-Yue Wang et al.   Frontiers in Cellular and Infection Microbiology

Monoclonal Antibodies B38 and H4 Produced in Nicotiana benthamiana Neutralize SARS-CoV-2 in vitro

(2020) Balamurugan Shanmugaraj et al.   Frontiers in Plant Science

Current state-of-the-art in plant-based antibody production systems

(2019) Marcello Donini et al.   BIOTECHNOLOGY LETTERS

Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins

(2019) Stefan Schillberg et al.   Frontiers in Plant Science

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel multi-peptide subunit vaccine admixed with AddaVax adjuvant produces significant immunogenicity and protection against Proteus mirabilis urinary tract infection in mice model

(2018) Ehsan Choubini et al.   MOLECULAR IMMUNOLOGY

Identification of T helper (Th)1- and Th2-associated antigens of Cryptococcus neoformans in a murine model of pulmonary infection

(2018) Carolina Firacative et al.   Scientific Reports

Using the mouse to model human disease: increasing validity and reproducibility

(2016) Monica J. Justice et al.   Disease Models & Mechanisms

5′ and 3′ Untranslated Regions Strongly Enhance Performance of Geminiviral Replicons in Nicotiana benthamiana Leaves

(2016) Andrew G. Diamos et al.   Frontiers in Plant Science

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Molecular pharming’s foot in the FDA’s door: Protalix’s trailblazing story

(2015) Tsafrir S. Mor   BIOTECHNOLOGY LETTERS

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks

(2014) Maite Sabalza et al.   BIOTECHNOLOGY LETTERS

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Toward Animal Cell Culture-Based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity

(2012) J. Hutter et al.   JOURNAL OF IMMUNOLOGY

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The production of hemagglutinin-based virus-like particles in plants: a rapid, efficient and safe response to pandemic influenza

(2010) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY