Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies
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Title
Senescence-Induced Chemoresistance in Triple Negative Breast Cancer and Evolution-Based Treatment Strategies
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-06-24
DOI
10.3389/fonc.2021.674354
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Note: Only part of the references are listed.- Cancer Response to Therapy-Induced Senescence: A Matter of Dose and Timing
- (2021) Maria Patrizia Mongiardi et al. Cancers
- Immune Checkpoint Inhibitors in Triple Negative Breast Cancer Treatment: Promising Future Prospects
- (2021) Remy Thomas et al. Frontiers in Oncology
- Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?
- (2021) José Antonio de Mera-Rodríguez et al. Frontiers in Cell and Developmental Biology
- Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
- (2020) Francisco Triana-Martínez et al. Cells
- Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
- (2020) Marcus Ruscetti et al. CELL
- Biology of extracellular vesicles secreted from senescent cells as senescence‐associated secretory phenotype factors
- (2020) Tomoka Misawa et al. Geriatrics & Gerontology International
- Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
- (2020) Xia Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks
- (2020) Corinne Abbadie et al. TRENDS IN BIOCHEMICAL SCIENCES
- Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
- (2020) Anthony M. Battram et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic
- (2020) Irene Galiana et al. JOURNAL OF CONTROLLED RELEASE
- Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X L –BAX interaction
- (2020) Tareq Saleh et al. Molecular Oncology
- The Premature Senescence in Breast Cancer Treatment Strategy
- (2020) Małgorzata Milczarek Cancers
- Senescence-Associated Pro-inflammatory Cytokines and Tumor Cell Plasticity
- (2020) Jean Paul Vernot Frontiers in Molecular Biosciences
- New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer
- (2020) Ye Han et al. Frontiers in Oncology
- Sensitization of ovarian tumor to immune checkpoint blockade by boosting senescence-associated secretory phenotype
- (2020) Xue Hao et al. iScience
- The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases
- (2020) Lorenzo Cuollo et al. Biology-Basel
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities
- (2019) Larissa G.P. Langhi Prata et al. SEMINARS IN IMMUNOLOGY
- A decade of clinical development of PARP inhibitors in perspective
- (2019) J Mateo et al. ANNALS OF ONCOLOGY
- First Strike–Second Strike Strategies in Metastatic Cancer: Lessons from the Evolutionary Dynamics of Extinction
- (2019) Robert A. Gatenby et al. CANCER RESEARCH
- Different sensitivities of senescent breast cancer cells to immune cell‐mediated cytotoxicity
- (2019) Touko Inao et al. CANCER SCIENCE
- Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
- (2019) Mikolaj Ogrodnik et al. TRENDS IN BIOCHEMICAL SCIENCES
- ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation
- (2019) Luciana Rodrigues Gomes et al. Cell Death & Disease
- Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
- (2019) Hubert Fleury et al. Nature Communications
- Hallmarks of senescence and aging
- (2019) Slavica Dodig et al. Biochemia Medica
- Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge
- (2019) Nedeljković et al. Cells
- Targeting senescent cells: approaches, opportunities, challenges
- (2019) Cayetano von Kobbe Aging-US
- Cisplatin-resistant triple-negative breast cancer subtypes: multiple mechanisms of resistance
- (2019) David P. Hill et al. BMC CANCER
- TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
- (2019) Kana Tominaga et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Identification and characterization of Cardiac Glycosides as senolytic compounds
- (2019) Francisco Triana-Martínez et al. Nature Communications
- Immune induction strategies to enhance responses to PD-1 blockade: lessons from the TONIC trial
- (2019) Sandra Demaria et al. Journal for ImmunoTherapy of Cancer
- Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents
- (2019) Agnieszka Bojko et al. Cells
- Oncogene-induced senescence: a double edged sword in cancer
- (2018) Xue-ling Liu et al. ACTA PHARMACOLOGICA SINICA
- Senescence Elicits Stemness: A Surprising Mechanism for Cancer Relapse
- (2018) Zhixun Dou et al. Cell Metabolism
- Advances in the systemic treatment of triple-negative breast cancer
- (2018) J.M. Lebert et al. Current Oncology
- A versatile drug delivery system targeting senescent cells
- (2018) Daniel Muñoz‐Espín et al. EMBO Molecular Medicine
- Survivin Inhibitors Mitigate Chemotherapeutic Resistance in Breast Cancer Cells by Suppressing Genotoxic Nuclear Factor-κB Activation
- (2018) Wei Wang et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The ATF6α arm of the Unfolded Protein Response mediates replicative senescence in human fibroblasts through a COX2/prostaglandin E 2 intracrine pathway
- (2018) Johanna Cormenier et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Metronomic combination of vinorelbine and 5Fluorouracil inhibit triple-negative breast cancer cells results from the proof-of-concept VICTOR-0 study
- (2018) Maria Grazia Cerrito et al. Oncotarget
- Horizons in the evolution of aging
- (2018) Thomas Flatt et al. BMC BIOLOGY
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Triple-Negative Breast Cancers: Systematic Review of the Literature on Molecular and Clinical Features with a Focus on Treatment with Innovative Drugs
- (2018) Anna Diana et al. Current Oncology Reports
- Senescent tumor cells building three-dimensional tumor clusters
- (2018) Hyun-Gyu Lee et al. Scientific Reports
- Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells
- (2018) Sylvia S. Gayle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
- (2017) Birgit Ritschka et al. GENES & DEVELOPMENT
- Extinction rates in tumour public goods games
- (2017) Philip Gerlee et al. Journal of the Royal Society Interface
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- Senescent tumor cells lead the collective invasion in thyroid cancer
- (2017) Young Hwa Kim et al. Nature Communications
- Senoptosis: non-lethal DNA cleavage as a route to deep senescence
- (2017) Maja Studencka et al. Oncotarget
- Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells
- (2017) E L Kavanagh et al. Oncogenesis
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Metronomic chemotherapy for triple negative breast cancer?
- (2016) Teresa Di Desidero et al. Aging-US
- Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence
- (2016) Haoran Tai et al. Autophagy
- How autophagy both activates and inhibits cellular senescence
- (2016) Chanhee Kang et al. Autophagy
- Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
- (2016) Tobias Eggert et al. CANCER CELL
- Epigenetic Mechanisms of Longevity and Aging
- (2016) Payel Sen et al. CELL
- Chromosome organisation during ageing and senescence
- (2016) Tamir Chandra et al. CURRENT OPINION IN CELL BIOLOGY
- Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype
- (2016) Nicolas Malaquin et al. EXPERIMENTAL GERONTOLOGY
- A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses
- (2016) Eric H. Bent et al. GENES & DEVELOPMENT
- Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review
- (2016) Michael C. Velarde et al. GERONTOLOGY
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- (2016) B. I. Gerashchenko et al. HISTOCHEMISTRY AND CELL BIOLOGY
- RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis
- (2016) Marina Lesina et al. JOURNAL OF CLINICAL INVESTIGATION
- The cell fate: senescence or quiescence
- (2016) Menderes Yusuf Terzi et al. MOLECULAR BIOLOGY REPORTS
- A large fraction of HLA class I ligands are proteasome-generated spliced peptides
- (2016) Juliane Liepe et al. SCIENCE
- Senescence of T Lymphocytes: Implications for Enhancing Human Immunity
- (2016) Arne N. Akbar et al. TRENDS IN IMMUNOLOGY
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- Cumulative defects in DNA repair pathways drive the PARP inhibitor response in high-grade serous epithelial ovarian cancer cell lines
- (2016) Hubert Fleury et al. Oncotarget
- ATF6α regulates morphological changes associated with senescence in human fibroblasts
- (2016) Clémentine Druelle et al. Oncotarget
- Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment
- (2016) Larisa V. Kovtonyuk et al. Frontiers in Immunology
- Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
- (2016) Mikhail V. Blagosklonny Aging-US
- The unfolded protein response and cellular senescence. A Review in the Theme: Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease
- (2015) Olivier Pluquet et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Application of Evolutionary Principles to Cancer Therapy
- (2015) P. M. Enriquez-Navas et al. CANCER RESEARCH
- The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells
- (2015) Luis Jaime Castro-Vega et al. CARCINOGENESIS
- Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment
- (2015) Anna E. Vilgelm et al. JNCI-Journal of the National Cancer Institute
- Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer
- (2015) Marco Archetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Connecting the Dots: Therapy-Induced Senescence and a Tumor-Suppressive Immune Microenvironment
- (2015) Anna E. Vilgelm et al. JNCI-Journal of the National Cancer Institute
- ATF6 Mediates a Pro-Inflammatory Synergy Between ER Stress and TLR Activation in the Pathogenesis of Liver Ischemia-Reperfusion Injury
- (2014) J. Rao et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Inhibition of poly(ADP-ribosyl)ation in cancer: Old and new paradigms revisited
- (2014) Barbara Lupo et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Cellular senescence and its effector programs
- (2014) R. Salama et al. GENES & DEVELOPMENT
- Sweat but no gain: Inhibiting proliferation of multidrug resistant cancer cells with “ersatzdroges”
- (2014) Yoonseok Kam et al. INTERNATIONAL JOURNAL OF CANCER
- Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer
- (2014) Hanna K. Sanoff et al. JNCI-Journal of the National Cancer Institute
- Life gained, years lost?
- (2014) David Killock Nature Reviews Clinical Oncology
- Herbicide resistance modelling: past, present and future
- (2014) Michael Renton et al. PEST MANAGEMENT SCIENCE
- Autophagy and senescence
- (2013) David A. Gewirtz Autophagy
- Evolutionary game theory of growth factor production: implications for tumour heterogeneity and resistance to therapies
- (2013) M Archetti BRITISH JOURNAL OF CANCER
- The Regulation of Cell Size
- (2013) Alison C. Lloyd CELL
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
- (2013) M. Sadaie et al. GENES & DEVELOPMENT
- Lysosome-mediated processing of chromatin in senescence
- (2013) Andre Ivanov et al. JOURNAL OF CELL BIOLOGY
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
- (2013) Alexandre Iannello et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- (2013) Jan R. Dörr et al. NATURE
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Wnt signaling potentiates nevogenesis
- (2013) J. S. Pawlikowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Senescence Sensitivity of Breast Cancer Cells Is Defined by Positive Feedback Loop between CIP2A and E2F1
- (2013) Anni Laine et al. Cancer Discovery
- Emerging targeted therapies in triple-negative breast cancer
- (2012) J. Crown et al. ANNALS OF ONCOLOGY
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
- (2012) James G. Jackson et al. CANCER CELL
- Increased autophagic activity in senescent human dental pulp cells
- (2012) L. Li et al. INTERNATIONAL ENDODONTIC JOURNAL
- Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
- (2012) Jonathan Ledermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK
- (2012) Arvin B. Tam et al. PLoS One
- Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
- (2012) Rafael Solana et al. SEMINARS IN IMMUNOLOGY
- Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
- (2012) J Cahu et al. Cell Death & Disease
- Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence
- (2012) C Drullion et al. Cell Death & Disease
- Triple-negative and basal-like breast cancer: implications for oncologists
- (2011) J. Lachapelle et al. Current Oncology
- Autophagy May Precede Cellular Senescence of Bile Ductular Cells in Ductular Reaction in Primary Biliary Cirrhosis
- (2011) Motoko Sasaki et al. DIGESTIVE DISEASES AND SCIENCES
- Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species
- (2011) Santhi Achuthan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
- (2011) Brian D. Lehmann et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy as a target for anticancer therapy
- (2011) Filip Janku et al. Nature Reviews Clinical Oncology
- Immune parameters affecting the efficacy of chemotherapeutic regimens
- (2011) Laurence Zitvogel et al. Nature Reviews Clinical Oncology
- SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
- (2011) C Canino et al. ONCOGENE
- Triple-Negative Breast Cancer: An Unmet Medical Need
- (2011) C. A. Hudis et al. ONCOLOGIST
- Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
- (2011) Hyun Tae Kang et al. PLoS One
- Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
- (2011) W. W. Pang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular senescence: A link between cancer and age-related degenerative disease?
- (2011) Judith Campisi et al. SEMINARS IN CANCER BIOLOGY
- Cellular Senescence: Many Roads, One Final Destination
- (2011) Raya Saab TheScientificWorldJOURNAL
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Plasma membrane microdomains in aging and disease
- (2010) Yoshiko Ohno-Iwashita et al. Geriatrics & Gerontology International
- Therapy-Induced Senescence in Cancer
- (2010) Jonathan A. Ewald et al. JNCI-Journal of the National Cancer Institute
- Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis
- (2010) Motoko Sasaki et al. LABORATORY INVESTIGATION
- Targeting breast cancer stem cells
- (2010) Sean P. McDermott et al. Molecular Oncology
- MnSOD Upregulation Induces Autophagic Programmed Cell Death in Senescent Keratinocytes
- (2010) Emeric Deruy et al. PLoS One
- Senescent Keratinocytes Die by Autophagic Programmed Cell Death
- (2009) Karo Gosselin et al. AMERICAN JOURNAL OF PATHOLOGY
- The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer
- (2009) Marieke E. Straver et al. BREAST CANCER RESEARCH AND TREATMENT
- A comparative analysis of the cell biology of senescence and aging
- (2009) Eun Seong Hwang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Autophagy mediates the mitotic senescence transition
- (2009) A. R.J. Young et al. GENES & DEVELOPMENT
- Generation of an epigenetic signature by chronic hypoxia in prostate cells
- (2009) J. A. Watson et al. HUMAN MOLECULAR GENETICS
- Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers
- (2009) M. Santarosa et al. MOLECULAR CANCER THERAPEUTICS
- Thymic involution and immune reconstitution
- (2009) Heather E. Lynch et al. TRENDS IN IMMUNOLOGY
- Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
- (2008) Susann Patschan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Triple-Negative Breast Cancer: Risk Factors to Potential Targets
- (2008) B. P. Schneider et al. CLINICAL CANCER RESEARCH
- The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
- (2008) Paola Allavena et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
- (2008) X. Li et al. JNCI-Journal of the National Cancer Institute
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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