LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

(2021) Pojeong Park et al.   Nature Communications

LIMK1 nuclear translocation promotes hepatocellular carcinoma progression by increasing p-ERK nuclear shuttling and by activating c-Myc signalling upon EGF stimulation

(2021) Zhihua Pan et al.   ONCOGENE

Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia

(2021) Sylvie Gory-Fauré et al.   Frontiers in Pharmacology

Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation

(2021) Peng Chen et al.   Cell Death & Disease

Dendritic Spines in Alzheimer’s Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure

(2020) Silvia Pelucchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration

(2020) Anjali Bisaria et al.   SCIENCE

Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function

(2020) Marina I. Oliveira da Silva et al.   Frontiers in Cell and Developmental Biology

Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

(2020) Laxmi Kumar Parajuli et al.   eNeuro

Dementia with Lewy bodies: an update and outlook

(2019) Tiago Fleming Outeiro et al.   Molecular Neurodegeneration

A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders

(2019) Claudia Bagni et al.   NEURON

FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation

(2019) Jonas Feuge et al.   CEREBRAL CORTEX

α-Synuclein in Parkinson’s disease: causal or bystander?

(2019) Peter Riederer et al.   JOURNAL OF NEURAL TRANSMISSION

Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons

(2019) Roberta Pennucci et al.   PLoS One

Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid

(2019) Benjamin W. Henderson et al.   Science Signaling

Altered Neocortical Dynamics in a Mouse Model of Williams–Beuren Syndrome

(2019) Miguel Dasilva et al.   MOLECULAR NEUROBIOLOGY

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

(2019) David E. Kang et al.   JOURNAL OF ALZHEIMERS DISEASE

Integrin activity in neuronal connectivity

(2018) Johanna Lilja et al.   JOURNAL OF CELL SCIENCE

Imbalance of synaptic actin dynamics as a key to fragile X syndrome?

(2018) Kristin Michaelsen-Preusse et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins

(2018) Jelena Borovac et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dendritic spine actin cytoskeleton in autism spectrum disorder

(2018) Merja Joensuu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Activation of Entorhinal Cortical Projections to the Dentate Gyrus Underlies Social Memory Retrieval

(2018) Celeste Leung et al.   Cell Reports

The Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory

(2018) Sreetama Basu et al.   Frontiers in Molecular Neuroscience

An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction

(2018) Chen Tian et al.   Frontiers in Molecular Neuroscience

Fibrillar Amyloid-β1-42 Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase

(2018) Ariadna Mendoza-Naranjo et al.   JOURNAL OF ALZHEIMERS DISEASE

PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior

(2018) Yan Wang et al.   Cell Reports

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Loss and remodeling of striatal dendritic spines in Parkinson’s disease: from homeostasis to maladaptive plasticity?

(2017) Rosa M. Villalba et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction

(2017) Paula Lunardi et al.   MOLECULAR NEUROBIOLOGY

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment

(2017) Walter E. Kaufmann et al.   PEDIATRICS

Peptide regulation of cofilin activity in the CNS: A novel therapeutic approach for treatment of multiple neurological disorders

(2017) Alisa E. Shaw et al.   PHARMACOLOGY & THERAPEUTICS

Hyperactive locomotion in aDrosophilamodel is a functional readout for the synaptic abnormalities underlying fragile X syndrome

(2017) Risa Kashima et al.   Science Signaling

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

LIM kinases: cofilin and beyond

(2017) Chloé Prunier et al.   Oncotarget

Structural basis for CRMP2-induced axonal microtubule formation

(2017) Shinsuke Niwa et al.   Scientific Reports

Hyperactive locomotion in aDrosophilamodel is a functional readout for the synaptic abnormalities underlying fragile X syndrome

(2017) Risa Kashima et al.   Science Signaling

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

(2017) Alexander Pyronneau et al.   Science Signaling

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

(2017) Emanuela Santini et al.   Science Signaling

Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats

(2017) Fei Han et al.   PLoS One

Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice

(2017) D. Gagnon et al.   Scientific Reports

Actin dynamics and cofilin-actin rods in alzheimer disease

(2016) James R. Bamburg et al.   Cytoskeleton

Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer’s Disease

(2016) Yulei Deng et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization

(2016) An Liu et al.   JOURNAL OF CELL BIOLOGY

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain

(2016) Benjamin W. Henderson et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic AMPA receptor composition in development, plasticity and disease

(2016) Jeremy M. Henley et al.   NATURE REVIEWS NEUROSCIENCE

Extensive phosphorylation of AMPA receptors in neurons

(2016) Graham H. Diering et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome

(2016) Cristina Borralleras et al.   Molecular Brain

Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome

(2016) Risa Kashima et al.   Science Signaling

The Role of Actin Cytoskeleton in Memory Formation in Amygdala

(2016) Raphael Lamprecht   Frontiers in Molecular Neuroscience

Mouse Genetic Models of Human Brain Disorders

(2016) Celeste Leung et al.   Frontiers in Genetics

State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines

(2016) Jun Noguchi et al.   Scientific Reports

Attention-Deficit/Hyperactivity Disorder–like Phenotype in a Mouse Model with Impaired Actin Dynamics

(2015) Anika-Maria Zimmermann et al.   BIOLOGICAL PSYCHIATRY

Genetic Risk for Schizophrenia: Convergence on Synaptic Pathways Involved in Plasticity

(2015) Jeremy Hall et al.   BIOLOGICAL PSYCHIATRY

Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia

(2015) Dibyadeep Datta et al.   BIOLOGICAL PSYCHIATRY

Roles of LIM kinases in central nervous system function and dysfunction

(2015) H. Cuberos et al.   FEBS LETTERS

Actin Out: Regulation of the Synaptic Cytoskeleton

(2015) Erin F. Spence et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LIMK1 Regulates Long-Term Memory and Synaptic Plasticity via the Transcriptional Factor CREB

(2015) Zarko Todorovski et al.   MOLECULAR AND CELLULAR BIOLOGY

CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases

(2015) T T Quach et al.   MOLECULAR PSYCHIATRY

Dysregulation and restoration of translational homeostasis in fragile X syndrome

(2015) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Altered Neuronal and Circuit Excitability in Fragile X Syndrome

(2015) Anis Contractor et al.   NEURON

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity

(2015) Joju George et al.   eLife

Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”

(2015) Sylwia Owczarek et al.   NEURAL PLASTICITY

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

(2014) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis

(2014) Michael Wolf et al.   CEREBRAL CORTEX

Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion

(2014) Anaël Chazeau et al.   EMBO JOURNAL

Heterozygous deletion of the Williams–Beuren syndrome critical interval in mice recapitulates most features of the human disorder

(2014) Maria Segura-Puimedon et al.   HUMAN MOLECULAR GENETICS

Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton

(2014) Mohamad R. Khazaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder

(2014) Z Zhao et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Autism: cause factors, early diagnosis and therapies

(2014) Shreya Bhat et al.   REVIEWS IN THE NEUROSCIENCES

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

(2014) Johanna Neuner et al.   Nature Communications

From Kanner to DSM-5: Autism as an Evolving Diagnostic Concept

(2013) Fred R. Volkmar et al.   Annual Review of Clinical Psychology

Electrical Compartmentalization in Dendritic Spines

(2013) Rafael Yuste   Annual Review of Neuroscience

Phosphorylation of Cofilin Regulates Extinction of Conditioned Aversive Memory via AMPAR Trafficking

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance

(2013) Conor Liston et al.   NATURE NEUROSCIENCE

Exploring the Multifactorial Nature of Autism Through Computational Systems Biology: Calcium and the Rho GTPase RAC1 Under the Spotlight

(2013) Fares Zeidán-Chuliá et al.   NEUROMOLECULAR MEDICINE

Reversal of Behavioral Deficits and Synaptic Dysfunction in Mice Overexpressing Neuregulin 1

(2013) Dong-Min Yin et al.   NEURON

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex

(2013) S Fatemi et al.   Molecular Autism

Growth Defects and Impaired Cognitive–Behavioral Abilities in Mice with Knockout for Eif4h, a Gene Located in the Mouse Homolog of the Williams-Beuren Syndrome Critical Region

(2012) Simona Capossela et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of LRRK2-Mediated Neurodegeneration

(2012) Elpida Tsika et al.   Current Neurology and Neuroscience Reports

The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines

(2012) Takeo Saneyoshi et al.   Cytoskeleton

Role of  -Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus

(2012) B. Winner et al.   JOURNAL OF NEUROSCIENCE

Quantitative analysis of gray and white matter in Williams syndrome

(2012) Andreia Vasconcellos Faria et al.   NEUROREPORT

Electrical Advantages of Dendritic Spines

(2012) Allan T. Gulledge et al.   PLoS One

Cofilin under control of  -arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning

(2012) C. G. Pontrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Rho GTPases and their role in organizing the actin cytoskeleton

(2011) S.-T. Sit et al.   JOURNAL OF CELL SCIENCE

GluA2 (GluR2) Regulates Metabotropic Glutamate Receptor-Dependent Long-Term Depression through N-Cadherin-Dependent and Cofilin-Mediated Actin Reorganization

(2011) Z. Zhou et al.   JOURNAL OF NEUROSCIENCE

LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators

(2011) Fabrizio Manetti   MEDICINAL RESEARCH REVIEWS

Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)

(2011) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression

(2011) Brice V McConnell et al.   Molecular Cancer

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride

(2011) Y. Hou et al.   NEUROSCIENCE

Dynamics of the Rho-family small GTPases in actin regulation and motility

(2011) Désirée Spiering et al.   Cell Adhesion & Migration

The Roles of the Actin Cytoskeleton in Fear Memory Formation

(2011) Raphael Lamprecht   Frontiers in Behavioral Neuroscience

Essential role of the N-terminal region of TFII-I in viability and behavior

(2010) Jaume Lucena et al.   BMC Medical Genetics

LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin

(2010) Genevieve S. Yuen et al.   BRAIN RESEARCH

Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics

(2010) Marco B Rust et al.   EMBO JOURNAL

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

A Role for RhoB in Synaptic Plasticity and the Regulation of Neuronal Morphology

(2010) K. McNair et al.   JOURNAL OF NEUROSCIENCE

p21-Activated Kinases 1 and 3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties

(2010) W. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity

(2010) Jiaping Gu et al.   NATURE NEUROSCIENCE

AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation

(2010) M. A. Patterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

(2009) Kiran S Nadella et al.   EMBO REPORTS

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

Cytoskeletal Changes Underlie Estrogen's Acute Effects on Synaptic Transmission and Plasticity

(2009) E. A. Kramar et al.   JOURNAL OF NEUROSCIENCE

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

(2009) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic AMPA Receptor Plasticity and Behavior

(2009) Helmut W. Kessels et al.   NEURON

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Balancing Structure and Function at Hippocampal Dendritic Spines

(2008) Jennifer N Bourne et al.   Annual Review of Neuroscience

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

(2008) Lorenzo A. Cingolani et al.   NATURE REVIEWS NEUROSCIENCE

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function

(2008) Zikai Zhou et al.   NEUROPHARMACOLOGY

Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1)

(2008) Suhail Asrar et al.   NEUROPHARMACOLOGY

Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice

(2008) J.L. Spencer et al.   NEUROSCIENCE

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE