- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanisms of LRRK2-Mediated Neurodegeneration
Authors
Keywords
-
Journal
Current Neurology and Neuroscience Reports
Volume 12, Issue 3, Pages 251-260
Publisher
Springer Nature
Online
2012-03-23
DOI
10.1007/s11910-012-0265-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
- (2012) Youren Tong et al. Molecular Neurodegeneration
- Sequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability
- (2012) Anna Lavut et al. PLoS Genetics
- Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons
- (2011) Nigel Ramsden et al. ACS Chemical Biology
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- LRRK2 Parkinson disease mutations enhance its microtubule association
- (2011) Lauren R. Kett et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
- (2011) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- (2011) Zhaohui Liu et al. HUMAN MOLECULAR GENETICS
- Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)
- (2011) Diane Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
- (2011) J. Dusonchet et al. JOURNAL OF NEUROSCIENCE
- LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool
- (2011) G. Piccoli et al. JOURNAL OF NEUROSCIENCE
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
- (2011) David Ramonet et al. PLoS One
- LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
- (2011) Jean-Marc Taymans et al. PLoS One
- The Parkinson's disease protein LRRK2 impairs proteasome substrate clearance without affecting proteasome catalytic activity
- (2011) M Lichtenberg et al. Cell Death & Disease
- Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation
- (2010) Zdenek Berger et al. BIOCHEMISTRY
- Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway
- (2010) Iria Carballo-Carbajal et al. CELLULAR SIGNALLING
- Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
- (2010) Tomoko Kanao et al. HUMAN MOLECULAR GENETICS
- MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2
- (2010) Cindy H. Hsu et al. JOURNAL OF NEUROCHEMISTRY
- Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
- (2010) Veronique Daniëls et al. JOURNAL OF NEUROCHEMISTRY
- LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3
- (2010) C.-H. Lin et al. JOURNAL OF NEUROSCIENCE
- Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
- (2010) Christian Johannes Gloeckner et al. JOURNAL OF PROTEOME RESEARCH
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
- (2010) H.L. Melrose et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
- (2010) H. Mortiboys et al. NEUROLOGY
- The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation
- (2010) Azad Kumar et al. PLoS One
- ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
- (2010) Karina Haebig et al. PLoS One
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
- (2010) Yulan Xiong et al. PLoS Genetics
- Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications
- (2009) Hong Qing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
- (2009) Elisa Greggio et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
- (2009) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Identification of the Autophosphorylation Sites of LRRK2
- (2009) Shogo Kamikawaji et al. BIOCHEMISTRY
- Mendelian forms of Parkinson's disease
- (2009) Thomas Gasser BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
- (2009) Saurabh Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?
- (2009) Frank Gillardon JOURNAL OF NEUROCHEMISTRY
- The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro
- (2009) Christian Johannes Gloeckner et al. JOURNAL OF NEUROCHEMISTRY
- Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease
- (2009) Shinji Higashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- Parkin Protects against LRRK2 G2019S Mutant-Induced Dopaminergic Neurodegeneration in Drosophila
- (2009) C.-H. Ng et al. JOURNAL OF NEUROSCIENCE
- The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration
- (2009) C. C.-Y. Ho et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- Microtubule assembly, organization and dynamics in axons and dendrites
- (2009) Cecilia Conde et al. NATURE REVIEWS NEUROSCIENCE
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
- (2009) Xian Lin et al. NEURON
- The WD40 Domain Is Required for LRRK2 Neurotoxicity
- (2009) Nathan D. Jorgensen et al. PLoS One
- R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
- (2009) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
- (2008) Saskia Biskup et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- LRRK2 regulates synaptic vesicle endocytosis
- (2008) Narae Shin et al. EXPERIMENTAL CELL RESEARCH
- The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation
- (2008) Elisa Greggio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
- (2008) Edward D. Plowey et al. JOURNAL OF NEUROCHEMISTRY
- The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
- (2008) Payal N. Gandhi et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson’s disease
- (2008) M. Westerlund et al. NEUROSCIENCE
- The biology and pathobiology of LRRK2: Implications for Parkinson's disease
- (2008) Darren J. Moore PARKINSONISM & RELATED DISORDERS
- A Drosophila model for LRRK2-linked parkinsonism
- (2008) Z. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
- (2008) J. Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now