Dementia with Lewy bodies: an update and outlook

Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity

(2018) Esteban Luna et al.   ACTA NEUROPATHOLOGICA

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

(2018) Kurt A. Jellinger et al.   BMC Medicine

Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis

(2018) Myrto Stylianou et al.   CLINICAL NEUROPHYSIOLOGY

123I-MIBG myocardial scintigraphy for the diagnosis of DLB: a multicentre 3-year follow-up study

(2018) Junji Komatsu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

(2018) Rita Guerreiro et al.   LANCET NEUROLOGY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Abnormalities of resting-state functional cortical connectivity in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

(2018) Claudio Babiloni et al.   NEUROBIOLOGY OF AGING

CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders

(2018) David J. Irwin et al.   NEUROLOGY

Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease

(2018) Diego Grassi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies

(2018) Paul C Donaghy et al.   PSYCHOLOGICAL MEDICINE

Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients

(2018) Luis R. Peraza et al.   Scientific Reports

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer’s-type dementia

(2018) Alan J. Thomas et al.   Alzheimers Research & Therapy

Clinical prevalence of Lewy body dementia

(2018) Joseph P. M. Kane et al.   Alzheimers Research & Therapy

The Genetics of Dementia with Lewy Bodies: Current Understanding and Future Directions

(2018) Tatiana Orme et al.   Current Neurology and Neuroscience Reports

Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: The DIAMOND Lewy study

(2018) Alan J. Thomas et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Alpha-synuclein deregulates the expression of COL4A2 and impairs ER-Golgi function

(2018) Isabel Paiva et al.   NEUROBIOLOGY OF DISEASE

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

(2018) Dennis W. Dickson et al.   NEUROLOGY

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

A new visual rating scale for Ioflupane imaging in Lewy body disease

(2018) Jim J. Lloyd et al.   NeuroImage-Clinical

Accuracy of clinical diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis

(2017) Giovanni Rizzo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Diagnostic Performance of the Visual Reading of123I-Ioflupane SPECT Images With or Without Quantification in Patients With Movement Disorders or Dementia

(2017) Jan Booij et al.   JOURNAL OF NUCLEAR MEDICINE

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

(2017) David J Irwin et al.   LANCET NEUROLOGY

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

(2017) Claudio Babiloni et al.   NEUROBIOLOGY OF AGING

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

A new potential biomarker for dementia with Lewy bodies

(2017) Vincenzo Donadio et al.   NEUROLOGY

An update on the genetics of dementia with Lewy bodies

(2017) Leonie J.M. Vergouw et al.   PARKINSONISM & RELATED DISORDERS

SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation

(2017) Ruth Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

(2017) Ricardo Gaspar et al.   QUARTERLY REVIEWS OF BIOPHYSICS

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

(2017) Rita Machado de Oliveira et al.   PLOS BIOLOGY

MAPT haplotype H1G is associated with increased risk of dementia with Lewy bodies

(2016) Catherine Labbé et al.   Alzheimers & Dementia

123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography and123I-metaiodobenzylguanidine myocardial scintigraphy in differentiating dementia with lewy bodies from other dementias: A comparative study

(2016) Pietro Tiraboschi et al.   ANNALS OF NEUROLOGY

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases

(2016) Lorna Harper et al.   BRAIN

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing

(2016) Kirsty E. McAleese et al.   BRAIN PATHOLOGY

Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource

(2016) Michael J. Keogh et al.   GENOME RESEARCH

Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study

(2016) Alan J. Thomas et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

EEG Markers of Dementia with Lewy Bodies: A Multicenter Cohort Study

(2016) Laura Bonanni et al.   JOURNAL OF ALZHEIMERS DISEASE

Arguing against the proposed definition changes of PD

(2016) Bradley F. Boeve et al.   MOVEMENT DISORDERS

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies

(2016) Joshua T. Geiger et al.   NEUROBIOLOGY OF DISEASE

Autopsy validation of 123 I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB

(2016) Alan J. Thomas et al.   NEUROLOGY

LRRK2 variation and dementia with Lewy bodies

(2016) Michael G. Heckman et al.   PARKINSONISM & RELATED DISORDERS

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons

(2016) Dorothea Pinotsi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

(2016) Marija Iljina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Prevalence of Submandibular Gland Synucleinopathy in Parkinson’s Disease, Dementia with Lewy Bodies and other Lewy Body Disorders

(2016) Thomas G. Beach et al.   Journal of Parkinsons Disease

Exome sequencing in dementia with Lewy bodies

(2016) M J Keogh et al.   Translational Psychiatry

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts

(2016) Marco Emanuele et al.   EBioMedicine

Phosphorylation induces distinct alpha-synuclein strain formation

(2016) Meng-Rong Ma et al.   Scientific Reports

Neuropathologically mixed Alzheimer’s and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes

(2015) Lauren Walker et al.   ACTA NEUROPATHOLOGICA

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

Quantitative electroencephalogram utility in predicting conversion of mild cognitive impairment to dementia with Lewy bodies

(2015) Laura Bonanni et al.   NEUROBIOLOGY OF AGING

Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

(2015) Zuzana Nedelska et al.   NEUROBIOLOGY OF AGING

Role for the microtubule-associated protein tau variant p.A152T in risk of α-synucleinopathies

(2015) Catherine Labbé et al.   NEUROLOGY

Clinicians' ability to diagnose dementia with Lewy bodies is not affected by  -amyloid load

(2015) P. Tiraboschi et al.   NEUROLOGY

Diagnostic Accuracy of 123I-Meta-Iodobenzylguanidine Myocardial Scintigraphy in Dementia with Lewy Bodies: A Multicenter Study

(2015) Mitsuhiro Yoshita et al.   PLoS One

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias

(2014) David R. Howlett et al.   BRAIN PATHOLOGY

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

(2014) Jose Bras et al.   HUMAN MOLECULAR GENETICS

18F-FDG PET and Perfusion SPECT in the Diagnosis of Alzheimer and Lewy Body Dementias

(2014) J. T. O'Brien et al.   JOURNAL OF NUCLEAR MEDICINE

Concomitant pathologies among a spectrum of parkinsonian disorders

(2014) Brittany N. Dugger et al.   PARKINSONISM & RELATED DISORDERS

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease

(2014) Marta Swirski et al.   Alzheimers Research & Therapy

Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation

(2014) Diana F. Lázaro et al.   PLoS Genetics

A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism

(2014) Eleanna Kara et al.   JAMA Neurology

Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series

(2013) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Confluence of α-Synuclein, Tau, and β-Amyloid Pathologies in Dementia With Lewy Bodies

(2013) Martí Colom-Cadena et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Young-onset parkinsonism due to homozygous duplication of α-synuclein in a consanguineous family

(2013) Maja Kojovic et al.   MOVEMENT DISORDERS

Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder

(2013) B.F. Boeve et al.   SLEEP MEDICINE

A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

(2013) Michael A. Nalls et al.   JAMA Neurology

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

(2013) Jon B Toledo et al.   Acta Neuropathologica Communications

Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia

(2012) Shinsuke Fujioka et al.   ACTA NEUROPATHOLOGICA

Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT

(2012) Shirlony Morgan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

(2012) J. M. Milber et al.   NEUROLOGY

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

(2012) C. Pacheco et al.   Frontiers in Physiology

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

(2011) Marie-Christine Chartier-Harlin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Familial Aggregation of Dementia With Lewy Bodies

(2011) Angela Nervi et al.   ARCHIVES OF NEUROLOGY

DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

(2011) Bram Meeus et al.   NEUROBIOLOGY OF AGING

Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies

(2011) T. J. Ferman et al.   NEUROLOGY

Low-resolution structure of a vesicle disrupting  -synuclein oligomer that accumulates during fibrillation

(2011) L. Giehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

(2010) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology

(2010) Albert Flotats et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

CSF synuclein: adding to the biomarker footprint of dementia with Lewy bodies

(2010) B. Mollenhauer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

(2009) Tetsuaki Arai et al.   ACTA NEUROPATHOLOGICA

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patients Homozygous and Heterozygous for SNCA Duplication in a Family With Parkinsonism and Dementia

(2008) Takeshi Ikeuchi et al.   ARCHIVES OF NEUROLOGY

Fitting Neurological Protein Aggregation Kinetic Data via a 2-Step, Minimal/“Ockham's Razor” Model:  The Finke−Watzky Mechanism of Nucleation Followed by Autocatalytic Surface Growth†

(2008) Aimee M. Morris et al.   BIOCHEMISTRY

Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis

(2008) E. J. Burton et al.   BRAIN

EEG comparisons in early Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease with dementia patients with a 2-year follow-up

(2008) L. Bonanni et al.   BRAIN

RESEARCH ARTICLE: Empiric Refinement of the Pathologic Assessment of Lewy-Related Pathology in the Dementia Patient

(2008) James B. Leverenz et al.   BRAIN PATHOLOGY

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience

(2008) Gabor G. Kovacs et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography

(2008) P Edison et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING

PROMINENT PSYCHIATRIC SYMPTOMS AND GLUCOSE HYPOMETABOLISM IN A FAMILY WITH A SNCA DUPLICATION

(2008) T. Uchiyama et al.   NEUROLOGY

INTRAFAMILIAL DIVERSITY OF PHENOTYPE ASSOCIATED WITH APP DUPLICATION

(2008) I. Guyant-Marechal et al.   NEUROLOGY

A novel PSEN2 mutation associated with a peculiar phenotype

(2008) P. Piscopo et al.   NEUROLOGY

Patterns and stages of  -synucleinopathy: Relevance in a population-based cohort

(2008) J. Zaccai et al.   NEUROLOGY

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype

(2008) K. A. Josephs et al.   NEUROLOGY

Relationship of phosphorylated α-synuclein and tau accumulation to Aβ deposition in the cerebral cortex of dementia with Lewy bodies

(2007) Kimiko Obi et al.   EXPERIMENTAL NEUROLOGY