Autophagy and Extracellular Vesicles, Connected to rabGTPase Family, Support Aggressiveness in Cancer Stem Cells

Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma

(2021) Karina Biserova et al.   Cells

Cancer stem cells in colorectal cancer and the association with chemotherapy resistance

(2021) Xue Lei et al.   MEDICAL ONCOLOGY

Targeting cancer stem cells in refractory cancer

(2021) Norikatsu Miyoshi et al.   Regenerative Therapy

Bone marrow mesenchymal stem cells enhance autophagy and help protect cells under hypoxic and retinal detachment conditions

(2020) Xin Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy

(2020) Chen Wang et al.   Stem Cell Research & Therapy

Autophagy in endothelial cells regulates their haematopoiesis-supporting ability

(2020) Zhong-Shi Lyu et al.   EBioMedicine

ERas Enhances Resistance to Cisplatin-Induced Apoptosis by Suppressing Autophagy in Gastric Cancer Cell

(2020) Huajian Tian et al.   Frontiers in Cell and Developmental Biology

Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype

(2020) Lei Liu et al.   EXPERIMENTAL CELL RESEARCH

Extracellular vesicle-associated miR-135b and -135a regulate stemness in Group 4 medulloblastoma cells by targeting angiomotin-like 2

(2020) Seung Ah Choi et al.   Cancer Cell International

Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species–induced autophagy

(2020) Nan Che et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells

(2019) Junlan Zhu et al.   ONCOGENE

Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases

(2019) Xiao Sun et al.   Stem Cell Research & Therapy

Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy

(2019) Nudjanad Heebkaew et al.   Biomed Research International

BRCA1 affects the resistance and stemness of SKOV3-derived ovarian cancer stem cells by regulating autophagy

(2019) Yue You et al.   Cancer Medicine

A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer

(2019) Junlan Zhu et al.   Cancers

Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma

(2019) Wei Li et al.   Molecular Cancer

Current Outlook on Autophagy in Human Leukemia: Foe in Cancer Stem Cells and Drug Resistance, Friend in New Therapeutic Interventions

(2019) Katharina Rothe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of cancer stem cells from human colon adenocarcinoma cell line HT-29 with resveratrol and sulindac induced mesenchymal-endothelial transition rate

(2019) Ayda Pouyafar et al.   CELL AND TISSUE RESEARCH

Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells

(2019) Mitsunobu Takeda et al.   CANCER RESEARCH

Reprogramming of cancer stem cells into non-tumorigenic cells using stem cell exosomes for cancer therapy

(2019) Kyoung Soo Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the Small GTPase Superfamily through their Regulatory Proteins

(2019) Janine L. Gray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

(2019) Milad Riazifar et al.   ACS Nano

RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells

(2019) Xianming Ding et al.   Autophagy

Chemotherapy-induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2

(2019) Meng Shen et al.   CANCER RESEARCH

Epigenetic silencing of Rab39a promotes epithelial to mesenchymal transition of cervical cancer through AKT signaling

(2019) Chun Zou et al.   EXPERIMENTAL CELL RESEARCH

RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

(2019) Wei‐Chung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

(2019) Liang Yang et al.   Molecular Cancer

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

Cancer-associated fibroblasts endow stem-like qualities to liver cancer cells by modulating autophagy

(2019) Zhenxiong Zhao et al.   Cancer Management and Research

Peglated-H1/pHGFK1 nanoparticles enhance anti-tumor effects of sorafenib by inhibition of drug-induced autophagy and stemness in renal cell carcinoma

(2019) Xiaoge Gao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy

(2019) Bin Zhao et al.   Oxidative Medicine and Cellular Longevity

CCND1 silencing suppresses liver cancer stem cell differentiation through inhibiting autophagy

(2019) Hongying Zhang   Human Cell

Glioblastoma Stem Cell-Derived Exosomes Enhance Stemness and Tumorigenicity of Glioma Cells by Transferring Notch1 Protein

(2019) Zhen Sun et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Downregulation of Rab17 promotes cell proliferation and invasion in non‐small cell lung cancer through STAT3/HIF‐1α/VEGF signaling

(2019) Mingliang Wang et al.   Thoracic Cancer

MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23

(2018) Hongyan Xue et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells

(2018) Xiangjie Kong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PGE2 /EP4 antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells

(2018) Meng-Chieh Lin et al.   INTERNATIONAL JOURNAL OF CANCER

Role of autophagy in breast cancer and breast cancer stem cells (Review)

(2018) Yanyan Han et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding

(2018) Danyue Peng et al.   LEUKEMIA

Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma

(2018) Zhonghu Li et al.   ONCOGENE

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

Prominent role of RAB39A-RXRB axis in cancer development and stemness

(2018) Tokuhiro Chano et al.   Oncotarget

Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

(2018) Jing Ren et al.   Theranostics

Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility

(2018) Norbert Kuc et al.   BIOCHEMICAL PHARMACOLOGY

Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-β Signaling

(2018) Li Zhang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness

(2018) Shu-Huei Cho et al.   Cell Death & Disease

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

(2018) Tanveer Sharif et al.   Cell Death & Disease

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance

(2018) Y.-B. Hu et al.   ONCOGENE

Autophagy suppresses self-renewal ability and tumorigenicity of glioma-initiating cells and promotes Notch1 degradation

(2018) Zhennan Tao et al.   Cell Death & Disease

Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma

(2018) Hyun Min Koh et al.   Thoracic Cancer

MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A

(2017) Cui Chang et al.   GENE

RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells

(2017) Thomas Stefan Worst et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6

(2017) Lawei Yang et al.   MOLECULAR CARCINOGENESIS

Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes

(2017) Yohsuke Yagi et al.   NEUROSCIENCE LETTERS

Autophagy inhibition reduces chemoresistance and tumorigenic potential of human ovarian cancer stem cells

(2017) Anna Pagotto et al.   Cell Death & Disease

Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells

(2017) Feixue Feng et al.   Oncology Letters

CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation

(2017) Xuan Li et al.   Nature Communications

Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer

(2017) Shreya Mitra et al.   Nature Communications

Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-κB signaling

(2017) Jia Liu et al.   Oncotarget

A Rab5 GTPase module is important for autophagosome closure

(2017) Fan Zhou et al.   PLoS Genetics

First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential

(2017) Carolina Balbi et al.   Stem Cells Translational Medicine

Autophagic homeostasis is required for the pluripotency of cancer stem cells

(2016) Tanveer Sharif et al.   Autophagy

Nanoparticle-facilitated autophagy inhibition promotes the efficacy of chemotherapeutics against breast cancer stem cells

(2016) Rong Sun et al.   BIOMATERIALS

Autophagy-deficiency in hepatic progenitor cells leads to the defects of stemness and enhances susceptibility to neoplastic transformation

(2016) Feng Xue et al.   CANCER LETTERS

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Exosomes in Human Breast Milk Promote EMT

(2016) W. Qin et al.   CLINICAL CANCER RESEARCH

Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis

(2016) Hong-Tai Tzeng et al.   CLINICAL CANCER RESEARCH

Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma

(2016) Yuan-Chiang Chung et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation

(2016) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain

(2016) Janet E. Baulch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+Hematopoietic Stem-Progenitor Cells

(2016) Maria Catalina Gomez-Puerto et al.   STEM CELLS

Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’

(2016) Soha Jawhari et al.   Cell Death & Disease

Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3

(2016) Dong Han et al.   Oncotarget

Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion

(2016) Feixue Feng et al.   Oncotarget

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells

(2016) Sandra Pinet et al.   Oncotarget

ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells

(2016) Shi-Wei Yang et al.   Oncotarget

BIX01294, an inhibitor of histone methyltransferase, induces autophagy-dependent differentiation of glioma stem-like cells

(2016) Iwona Anna Ciechomska et al.   Scientific Reports

Targeting exosomes from preadipocytes inhibits preadipocyte to cancer stem cell signaling in early-stage breast cancer

(2015) Ramkishore Gernapudi et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation

(2015) K Sugimachi et al.   BRITISH JOURNAL OF CANCER

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

(2015) S. Das et al.   DEVELOPMENT

High Rab27A expression indicates favorable prognosis in CRC

(2015) Chuanbing Shi et al.   Diagnostic Pathology

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner

(2015) Massimo Nabissi et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNAs in Salivary Exosome as Potential Biomarkers of Aging

(2015) Tatsuya Machida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions

(2015) J. Gambarte Tudela et al.   JOURNAL OF CELL SCIENCE

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

(2015) Ming-Chen Yang et al.   Molecular Cancer

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

(2015) Paola Maycotte et al.   MOLECULAR CANCER RESEARCH

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion

(2015) Donghua Geng et al.   TUMOR BIOLOGY

The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

(2015) Man-Li Luo et al.   Cell Reports

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

(2015) Dhruv Kumar et al.   Oncotarget

Direct Targeting of Rab-GTPase-Effector Interactions

(2014) Jochen Spiegel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The autophagic roles of Rab small GTPases and their upstream regulators

(2014) Zsuzsanna Szatmári et al.   Autophagy

Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma

(2014) Yuan-Chiang Chung et al.   BMC CANCER

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer

(2014) M.-L. Luo et al.   CANCER RESEARCH

Rab31 is expressed in neural progenitor cells and plays a role in their differentiation

(2014) Christelle En Lin Chua et al.   FEBS LETTERS

High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival

(2014) Qingqing Wang et al.   MEDICAL ONCOLOGY

Rab3a promotes brain tumor initiation and progression

(2014) Jun-Kyum Kim et al.   MOLECULAR BIOLOGY REPORTS

Proteomic Profiling of Exosomes Leads to the Identification of Novel Biomarkers for Prostate Cancer

(2014) Diederick Duijvesz et al.   PLoS One

Rab27a Was Identified as a Prognostic Biomaker by mRNA Profiling, Correlated with Malignant Progression and Subtype Preference in Gliomas

(2014) Hongjun Wang et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Chloroquine Eliminates Cancer Stem Cells Through Deregulation of Jak2 and DNMT1

(2014) Dong Soon Choi et al.   STEM CELLS

Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis

(2014) Chung-Han Tsai et al.   Nature Communications

Characterization of Cancer Stem-Like Cells Derived from Mouse Induced Pluripotent Stem Cells Transformed by Tumor-Derived Extracellular Vesicles

(2014) Ting Yan et al.   Journal of Cancer

Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance

(2013) Wen Yue et al.   Autophagy

Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment

(2013) Yu-jiao Song et al.   CANCER LETTERS

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules

(2013) Anand Ramteke et al.   MOLECULAR CARCINOGENESIS

Ypt1 recruits the Atg1 kinase to the preautophagosomal structure

(2013) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab27b regulates c-kit expression by controlling the secretion of stem cell factor

(2012) Chisato Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

(2012) Ying Zheng et al.   EXPERIMENTAL CELL RESEARCH

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

Beclin 1 and autophagy are required for the tumorigenicity of breast cancer stem-like/progenitor cells

(2012) C Gong et al.   ONCOGENE

Rab32 Is Important for Autophagy and Lipid Storage in Drosophila

(2012) Chao Wang et al.   PLoS One

Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma

(2012) Wei-Wei Dong   WORLD JOURNAL OF GASTROENTEROLOGY

Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy

(2012) Wen-Zhuo Zhuang et al.   Chinese Journal of Cancer

Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy

(2011) Wenzhuo Zhuang et al.   CANCER SCIENCE

Autophagy positively regulates the CD44+CD24-/lowbreast cancer stem-like phenotype

(2011) Sílvia Cufí et al.   CELL CYCLE

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Autophagy in Human Embryonic Stem Cells

(2011) Thien Tra et al.   PLoS One

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPases Regulating Phagosome Maturation Are Differentially Recruited to Mycobacterial Phagosomes

(2011) Shintaro Seto et al.   TRAFFIC

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions

(2009) Yuko Hirota et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Two Rabs for exosome release

(2009) Suzanne R. Pfeffer   NATURE CELL BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL