Article
Chemistry, Multidisciplinary
Jianran Hu, Ping Li, Baozhong Shi, Jun Tie
Summary: Saikosaponin D (SSD) can enhance cisplatin sensitivity of gastric cancer cells by inducing apoptosis and autophagy, and inhibiting the IKK beta/NF-κB signaling pathway.
Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Review
Oncology
Seog Young Kang, Dongwon Hwang, Soyoung Shin, Jinju Park, Myoungchan Kim, MD. Hasanur Rahman, Md. Ataur Rahman, Seong-Gyu Ko, Bonglee Kim
Summary: Bioactive food components from natural products play a crucial role in gastric cancer prevention and treatment, with potential mechanisms including suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Administering these natural bioactive food components may enhance the efficacy of gastric chemotherapy and minimize adverse effects, offering potential novel treatment strategies for gastric cancer management.
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Suyun Zhang, Rui Feng, Fang Yuan, Qiong Luo, Xiangqi Chen, Nan Li, Sheng Yang
Summary: Dihydroartemisinin (DHA) has therapeutic effects on cisplatin-resistant gastric cancer cells by enhancing autophagy, inducing apoptosis, and increasing cisplatin sensitivity.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Chenghao Li, Jiawei Li, Yan Li, Ling Li, Yali Luo, Junjie Li, Yiming Zhang, Yanru Wang, Xiuzhu Liu, Xiaotian Zhou, Hongxia Gong, Xiaojie Jin, Yongqi Liu
Summary: Isorhamnetin (ISO), a chemical substance derived from plants, has been found to have antitumor effects. In a hypoxic environment, ISO can significantly inhibit gastric cancer cell autophagy by targeting PI3K and blocking the PI3K-AKT-mTOR signaling pathway, as well as promote cell apoptosis, making it a promising candidate for the treatment of gastric cancer.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Ziqi Shang, Zhengdong Luo, Yifeng Wang, Qi Liu, Yiwei Xin, Mengjiao Zhang, Xinyang Li, Shunjie Zeng, Longchen Yu, Xin Zhang, Yi Zhang
Summary: In this study, the crucial role of circular RNAs (circRNAs) in cisplatin resistance in gastric cancer (GC) was reported for the first time. CircHIPK3 regulated cisplatin resistance by targeting autophagy and ferroptosis. Inhibition of circHIPK3 enhanced ferroptosis through the miR-508-3p/Bcl-2/beclin1/SLC7A11 axis, leading to decreased cisplatin resistance in GC cells. The results demonstrate that ferroptosis is a promising strategy to alleviate cisplatin resistance. Importantly, serum exosomal circHIPK3 could serve as a noninvasive indicator to evaluate cisplatin resistance in GC.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Meng Li, Hong-Yi Zhang, Rong-Gui Zhang
Summary: In this study, the role of MFAP2 in chemotherapy resistance in gastric cancer was investigated. It was found that upregulated MFAP2 contributed to increased resistance to chemotherapy drugs and achieved this through inducing autophagy. Therefore, MFAP2 may serve as a potential therapeutic target for overcoming chemotherapy resistance in gastric cancer patients.
Article
Biochemistry & Molecular Biology
Tae Woo Kim, Hee Gu Lee
Summary: The study found that APG can treat gastric cancer by promoting autophagic cell death, increasing levels of ATG5, LC3-II, and phosphorylation of AMPK and ULK1, while down-regulating p-mTOR and p62. Additionally, APG induces autophagic cell death through the activation of the PERK signaling, indicating an endoplasmic reticulum stress response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Article
Oncology
Lang Fang, Jialun Lv, Zhe Xuan, Bowen Li, Zheng Li, Zhongyuan He, Fengyuan Li, Jianghao Xu, Sen Wang, Yiwen Xia, Tianlu Jiang, Lu Zhang, Linjun Wang, Diancai Zhang, Hao Xu, Li Yang, Zekuan Xu, Weizhi Wang
Summary: This study reveals the crucial role of circCPM in regulating gastric cancer autophagy and 5-FU resistance by targeting PRKAA2. High expression of circCPM is positively associated with poor survival, and silencing circCPM significantly improves chemosensitivity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yuhao Luo, Siting Zheng, Qianying Wu, Jianhua Wu, Rui Zhou, Chunling Wang, Zhenzhen Wu, Xiaoxiang Rong, Na Huang, Li Sun, Jianping Bin, Yulin Liao, Min Shi, Wangjun Liao
Summary: Recent studies have shown that lncRNA EIF3J-DT is highly expressed in drug-resistant gastric cancer cells, contributing to chemoresistance by activating autophagy through targeting ATG14. This regulatory mechanism by EIF3J-DT may serve as a potential new target for enhancing chemosensitivity and improving prognosis in gastric cancer patients.
Review
Pharmacology & Pharmacy
Alexandra V. Avgustinovich, Olga V. Bakina, Sergey G. Afanas'ev, Olga V. Cheremisina, Liudmila V. Spirina, Alexey Y. Dobrodeev, Michail Buldakov, Evgeny L. Choynzonov
Summary: Gastric cancer is the second leading cause of cancer-related deaths worldwide, with surgical management being the best option. A combination of genetic and environmental factors explains poor prognosis. The use of nanoparticles in treating gastric cancer can enhance the effectiveness of anti-tumor therapy.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pharmacology & Pharmacy
Xu Liu, Qiaoyu Zheng, Qiongfang Yu, Yan Hu, Yanmin Cheng, Zhaozhao Shao, Li Chen, Wenjie Ding, Dian Gao
Summary: The study demonstrates that Apatinib inhibits the proliferation of GC cells by promoting apoptosis and autophagy, altering cell cycle distribution, and inhibiting invasion and migration capacities of GC cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Baiyang Shi, Jian Yang, Ji Wang
Summary: In this study, a newly proposed extended Galerkin method is used to investigate the dynamic response behavior of a generalized nonlinear dynamic system. The algebraic equations of vibration amplitudes are obtained through an integration of the weighted functions. The method is applicable to forced vibrations of nonlinear behavior and has been validated using the numerical Runge-Kutta method.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
Yan Guo, Bin Huang, Licheng Hua, Jianbin Chen, Ji Wang
Summary: This work aims to build a mathematical model for delaminated composite plates on an elastic foundation using an improved layerwise theory and finite element implementation. The model takes into account the transverse deformation of the foundation and investigates its effect on the dynamic characteristics of delaminated plates. The study considers different delamination and foundation parameters, as well as different stacking sequences.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
Jinghui Wu, Ji Wang, Longtao Xie, Sergei Zhgoon, Rongxing Wu, Aibing Zhang, Tingfeng Ma, Jianke Du
Summary: The Rayleigh-Ritz method is commonly used for analyzing free vibrations of elastic solids and structures. In this study, the Cartesian coordinate system is utilized for a simplified formulation and efficient evaluation of the vibrations of elastic ellipsoids. The procedure and formulation are validated by calculating the vibrations with geometric parameters and comparing them with known results and analysis from this study.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Chemistry, Multidisciplinary
Chencheng Lian, Ji Wang, Baochen Meng, Lihong Wang
Summary: This paper successfully solves the nonlinear differential equation of deflection of an elastic beam using the Galerkin method. It demonstrates the high consistency between the third-order approximate solution and the exact solution of the elliptic function. The effectiveness and advantages of the Galerkin method in solving nonlinear differential equations are further demonstrated.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Mechanical
Ji Lin, Jin Qian, Yu Xie, Ji Wang, Rui Xiao
Summary: In this study, a micromechanical mean-field shear transformation zone (STZ) model is developed to systematically describe the stress responses of amorphous polymers. The model captures the behaviors of amorphous polymers in various loading conditions and successfully reproduces the Bauschinger effect. The deformation-induced material polarization, in the form of an anisotropic distribution of STZs, is identified as the governing mechanism of the Bauschinger effect.
INTERNATIONAL JOURNAL OF PLASTICITY
(2023)
Article
Materials Science, Multidisciplinary
Yumei Chen, Xiang Fang, Ji Wang, Matteo Filippi, Erasmo Carrera
Summary: By using a microstructure with an antisymmetric dual helix, we designed a metamaterial plate with wide band gaps for phononic crystals. The band structure and displacement transmission curves of the metamaterial plates were calculated and compared with and without considering the mass in the center of the dual helix. The results show excellent consistency in the band gaps, and the effects of various parameters on the band gaps were examined for further evaluation of potential applications.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
Dongdong Guo, Haozhe Jiang, Lili Yuan, Tingfeng Ma, Jianke Du, Ji Wang
Summary: A metamaterial beam with carbon fiber-reinforced polymer (CFRP) is proposed to effectively reduce vibration. The dispersion curves are calculated using the transfer matrix method (TM), the frequency response is investigated using the spectral element method (SEM), and the displacement fields at different representative frequencies are displayed using the finite element method (FEM). Numerical analysis considers the effects of geometry, material parameters, and CFRP's cross-ply angle on the band gap, and three types of beams are discussed and compared. The results show that the cross-ply angle and length of CFRP significantly influence the band gaps, and the frequency and width of the band gaps vary when the CFRP layers are asymmetric. Experimental results agree well with numerical results in the low-frequency range for a CFRP beam with ten periods. These findings provide useful reference for the design optimization of metamaterial beams with wide band gaps, lightweight properties, and high strength.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Engineering, Mechanical
Chencheng Lian, Baochen Meng, Huimin Jing, Rongxing Wu, Ji Lin, Ji Wang
Summary: This study analyzed the higher-order nonlinear vibrations and mode couplings of beams using the extended Galerkin method for a better understanding of dynamic properties. Numerical solutions of frequencies and mode shapes were obtained for a cantilever beam by approximating and solving the vibration equation under large deformation. The results demonstrated that the approximate solutions were accurate compared to the exact solutions for small amplitudes.
JOURNAL OF VIBRATION ENGINEERING & TECHNOLOGIES
(2023)
Article
Physics, Applied
Jiachao Xu, Yuanzhen Zheng, Tingfeng Ma, Hui Chen, Bowei Wu, Ji Wang, Shuanghuizhi Li, Iren Kuznetsova, Ilya Nedospasov, Jianke Du, Hao Shi, Dudu Chen, Fei Sun
Summary: In this study, the topological valley Hall edge states of elastic waves in phononic crystals were achieved by utilizing material differences. A phononic crystal structure with lantern rings was proposed, and it was found that differences in Young's modulus or density of the lantern-ring materials can cause the destruction of the spatial inversion symmetry, leading to the emergence of topological edge states. By reconfiguring the waveguide path and changing the operating frequency through modifying the lantern-ring materials, the limitations of traditional methods based on structural parameter changes were overcome, providing a promising approach for elastic wave manipulation and communication.
PHYSICAL REVIEW APPLIED
(2023)
Review
Infectious Diseases
Bao Sun, Yingshuang Tang, Dan Chen, Yanning Bai, Yuanyuan Zhang, Suning Chen, Yi Qiao, Jingwen Wang
Summary: Biliary cryptococcal infection is rare and difficult to diagnose preoperatively. This case report and literature review collected a total of 12 reports of biliary cryptococcal infection from 1985 to 2021. Clinical manifestations were mainly jaundice, with bile duct dilatation and stenosis observed in vitro. Treatment with antifungal drugs resulted in symptom improvement or recovery in 66.67% of the cases. Early and accurate diagnosis is crucial for improving the cure rate of biliary cryptococcosis infected patients.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biology
Junyang Tan, Wenjun Wang, Xinjie Liu, Jinhong Xu, Yaping Che, Yanyan Liu, Jiaqiao Hu, Liubing Hu, Jianshuang Li, Qinghua Zhou
Summary: C11orf54 is a conserved ester hydrolase involved in DNA damage and repair. Knockdown of C11orf54 reduces cell proliferation and enhances cisplatin-induced DNA damage and apoptosis. The loss of C11orf54 leads to suppression of homologous recombination repair through decreased Rad51 expression.
COMMUNICATIONS BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yangyang Zhang, Qi Lai, He Zhang, Yingwu Yang, Ji Wang, Chaofeng Lu
Summary: In this study, an electromechanical model is established to consider the wheel-path distribution under actual traffic conditions. The optimal lateral embedded locations for PEH units should be adjusted according to the prescribed traffic speed of the roads, and these mathematical results serve as guidelines for selecting the optimal lateral embedded locations for PEH units.
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
J. H. Wu, J. Wang, E. Carrera, R. Augello
Summary: This work analyzes the wave propagation of Rayleigh type through a periodic elastic element covered with a T-plate. Viscous-spring artificial boundaries are used to satisfy the boundary conditions of the periodic structure. The Carrera Unified Formulation (CUF) is used to consistently express the various kinematics of the structure and obtain the wave propagation within the model. The numerical evaluation and comparison with analytical methods and COMSOL show that the results of this study are reliable and the developed model provides accurate analysis of T-plate periodic elastic structures.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Acoustics
Yurun Chen, Yan Guo, Rongxing Wu, Ji Wang, Huimin Jing, Ji Lin, Yahui Tian, Haifeng Zhang
Summary: The fast reduction in size of film bulk acoustic wave resonators results in enhanced electric fields and potential large deformations in operating devices. Therefore, the nonlinear behavior and accompanying properties of the resonator need to be considered in development and optimization for improved performance. A nonlinear formulation is presented for multilayered film bulk acoustic resonators, allowing analysis of vibration frequencies and mode shapes with consideration of larger mechanical deformations. Extensive research efforts have been made analytically and experimentally to understand the nonlinear behavior and properties, catering to the demands of communication and network technologies.
Article
Multidisciplinary Sciences
Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou
Summary: This article investigates the role of endonuclease G (ENDOG) in the cytosol. The authors find that cytoplasmic ENDOG activates the mTORC2 signaling pathway by competitively binding with 14-3-3 gamma and activates endoplasmic reticulum stress response by binding with Bip, leading to the development of nonalcoholic fatty liver disease.
NATURE COMMUNICATIONS
(2023)
