Journal
FEBS LETTERS
Volume 588, Issue 17, Pages 3186-3194Publisher
WILEY
DOI: 10.1016/j.febslet.2014.06.060
Keywords
Rab31; Neural progenitor cell; Differentiation
Funding
- National University of Singapore Graduate School for Integrative Sciences and Engineering (NGS)
- National Research Foundation, Singapore
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Rab31 is expressed in both GFAP- and nestin- positive fibres in regions of neurogenic potential in the adult mouse brain. To investigate the role of Rab31 in neural progenitor cells (NPCs), we cultured NPCs and found significant levels of Rab31 expression in these cells. Rab31 levels showed a sharp initial decrease and then reappeared gradually in a subpopulation of astrocytes when NPCs were induced to differentiate. Silencing of Rab31 hindered, while overexpression enhanced, the differentiation of NPCs to astrocytes. Our results suggest a previously unrecognised role for Rab31 in influencing the differentiation and fate of NPCs. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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