The Roles of the Let-7 Family of MicroRNAs in the Regulation of Cancer Stemness

Over-expression of CDX2 alleviates breast cancer by up-regulating microRNA let-7b and inhibiting COL11A1 expression

(2020) Hongbin Wang et al.   Cancer Cell International

CAIX-Mediated Control of LIN28/let-7 Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

(2020) Adriana Gibadulinova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial/mesenchymal heterogeneity of high‐grade serous ovarian carcinoma samples correlates with miRNA let‐7 levels and predicts tumor growth and metastasis

(2020) Evgeny Chirshev et al.   Molecular Oncology

MicroRNA let-7b inhibits cell proliferation via upregulation of p21 in hepatocellular carcinoma

(2020) Li Hui et al.   Cell and Bioscience

circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family

(2020) Xiaojin Song et al.   Molecular Therapy-Nucleic Acids

LIN28B promotes the development of neuroendocrine prostate cancer

(2020) Jessica Lovnicki et al.   JOURNAL OF CLINICAL INVESTIGATION

Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)

(2020) Weijun Hong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner

(2020) Shufeng Xu et al.   CANCER GENE THERAPY

The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let‐7i/TET3 pathway

(2020) Yawen Liu et al.   Molecular Oncology

An estimate of the total number of true human miRNAs

(2019) Julia Alles et al.   NUCLEIC ACIDS RESEARCH

Induction of breast cancer stem cells by M1 macrophages through Lin-28B-let-7-HMGA2 axis

(2019) Liang Guo et al.   CANCER LETTERS

LncRNA H19 promotes epithelial mesenchymal transition and metastasis of esophageal cancer via STAT3/EZH2 axis

(2019) Ming-Jiu Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MicroRNA-98-HMGA2-POSTN signal pathway reverses epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma

(2019) Minhui Zhu et al.   BIOMEDICINE & PHARMACOTHERAPY

Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP ‐1

(2019) Yang Zhang et al.   EMBO REPORTS

In silico identification of thiostrepton as an inhibitor of cancer stem cell growth and an enhancer for chemotherapy in non–small‐cell lung cancer

(2019) Tse‐Hung Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Matrine suppression of self‐renewal was dependent on regulation of LIN28A/Let‐7 pathway in breast cancer stem cells

(2019) Xiang Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation

(2019) Dan Yu et al.   Cell Communication and Signaling

MiR-146a promotes the asymmetric division and inhibits the self-renewal ability of breast cancer stem-like cells via indirect upregulation of Let-7

(2018) Rui Liang et al.   CELL CYCLE

Breast cancer stem-like cells are sensitized to tamoxifen induction of self-renewal inhibition with enforced Let-7c dependent on Wnt blocking

(2018) Xin Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Treating cancer with microRNA replacement therapy: A literature review

(2018) Nayer Hosseinahli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8

(2018) Chih-Yu Peng et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model

(2018) Lydia Meder et al.   ONCOGENE

H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7

(2018) Ni Kou et al.   ONCOLOGY RESEARCH

Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer

(2018) N. Hojo et al.   Scientific Reports

Let-7b attenuates cisplatin resistance and tumor growth in gastric cancer by targeting AURKB

(2018) Xiao Han et al.   CANCER GENE THERAPY

Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128

(2018) Feng He et al.   ONCOGENE

Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway

(2018) Jian-Lin Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells

(2018) Meng Wang et al.   CELL PROLIFERATION

Let-7 microRNA as a potential therapeutic target with implications for immunotherapy

(2018) Maud-Emmanuelle Gilles et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Post-transcriptional control of miRNA biogenesis

(2018) Gracjan Michlewski et al.   RNA

Nano Let-7b sensitization of eliminating esophageal cancer stem-like cells is dependent on blockade of Wnt activation of symmetric division

(2017) Yamei Pang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis

(2017) Hui-Huang Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

(2017) Jianbiao Zhou et al.   Journal of Hematology & Oncology

Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells

(2017) Seong-Joon Park et al.   JOURNAL OF RADIATION RESEARCH

Dovitinib enhances temozolomide efficacy in glioblastoma cells

(2017) Thatchawan Thanasupawat et al.   Molecular Oncology

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

(2017) F Peng et al.   ONCOGENE

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

(2017) Fei Peng et al.   Cell Death & Disease

MiR-129 blocks estrogen induction of NOTCH signaling activity in breast cancer stem-like cells

(2017) Guodong Xiao et al.   Oncotarget

Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

(2017) Alexandria C Wells et al.   eLife

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

(2016) Bin Jin et al.   BMC CANCER

Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells

(2016) X Sun et al.   CANCER GENE THERAPY

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

(2016) Jin Zhang et al.   Cell Stem Cell

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

The insights of Let-7 miRNAs in oncogenesis and stem cell potency

(2016) Xin Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Let-7 miRNAs sensitize breast cancer stem cells to radiation-induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathway

(2016) Huifang Sun et al.   Molecular Medicine Reports

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing

(2016) Nils Degrauwe et al.   Cell Reports

In vivo delivery of miRNAs for cancer therapy: Challenges and strategies

(2015) Yunching Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes

(2015) Haiqing Hu et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

Combined Delivery of Let-7b MicroRNA and Paclitaxel via Biodegradable Nanoassemblies for the Treatment of KRAS Mutant Cancer

(2015) Xin Dai et al.   MOLECULAR PHARMACEUTICS

Inhibition of c-Myc by let-7b mimic reverses mutidrug resistance in gastric cancer cells

(2015) XIAOJUN YANG et al.   ONCOLOGY REPORTS

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Let-7a suppresses glioma cell proliferation and invasion through TGF-β/Smad3 signaling pathway by targeting HMGA2

(2015) Yang Li et al.   TUMOR BIOLOGY

LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program

(2015) Xing-gang Mao et al.   Oncotarget

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma

(2015) Ann M. Lozier et al.   Oncotarget

Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models

(2014) Liem H. Nguyen et al.   CANCER CELL

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

The Naive State of Human Pluripotent Stem Cells: A Synthesis of Stem Cell and Preimplantation Embryo Transcriptome Analyses

(2014) Kevin Huang et al.   Cell Stem Cell

Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition

(2014) MAHESH APPARI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC

(2014) Maroof Alam et al.   MOLECULAR CANCER RESEARCH

Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy

(2014) Carla L Esposito et al.   MOLECULAR THERAPY

Differentially Expressed miRNAs in Cancer-Stem-Like Cells: Markers for Tumor Cell Aggressiveness of Pancreatic Cancer

(2014) Bin Bao et al.   STEM CELLS AND DEVELOPMENT

The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-κB

(2014) Rongrong Jiang et al.   TOXICOLOGY LETTERS

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

Reexpression of Let-7g MicroRNA Inhibits the Proliferation and Migration via K-Ras/HMGA2/Snail Axis in Hepatocellular Carcinoma

(2014) Ke-ji Chen et al.   Biomed Research International

let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

(2014) M. Patterson et al.   Stem Cell Reports

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Lin28: Primal Regulator of Growth and Metabolism in Stem Cells

(2013) Ng Shyh-Chang et al.   Cell Stem Cell

Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties

(2013) GUOPEI LUO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Wnt- -catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion

(2013) W.-Y. Cai et al.   JOURNAL OF CELL SCIENCE

Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

(2013) Aamir Ahmad et al.   Journal of Hematology & Oncology

Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells

(2013) Edwin A. Paz et al.   MOLECULAR CARCINOGENESIS

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

Impaired DICER1 function promotes stemness and metastasis in colon cancer

(2013) M S Iliou et al.   ONCOGENE

MicroRNAs and cancer stem cells: the sword and the shield

(2013) X Sun et al.   ONCOGENE

Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells

(2013) Yujie Liu et al.   PLoS One

The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

(2013) Eva Wessel Stratford et al.   Cancer Medicine

Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin

(2013) J Cai et al.   Oncogenesis

Extracellular vesicles in physiological and pathological conditions

(2012) Yuana Yuana et al.   BLOOD REVIEWS

Loss of Dicer expression is associated with breast cancer progression and recurrence

(2012) Sarkawt M. Khoshnaw et al.   BREAST CANCER RESEARCH AND TREATMENT

Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia

(2012) Dan-Xia Zhu et al.   CANCER SCIENCE

LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells

(2012) Jun Cho et al.   CELL

Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer

(2012) Areeg Faggad et al.   HISTOPATHOLOGY

Immunohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances

(2012) Guo-shun Shu et al.   PATHOLOGY RESEARCH AND PRACTICE

MicroRNA let-7c Is Downregulated in Prostate Cancer and Suppresses Prostate Cancer Growth

(2012) Nagalakshmi Nadiminty et al.   PLoS One

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

RETRACTED: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

(2011) Bin Bao et al.   CANCER LETTERS

Metformin Inhibits Cell Proliferation, Migration and Invasion by Attenuating CSC Function Mediated by Deregulating miRNAs in Pancreatic Cancer Cells

(2011) B. Bao et al.   Cancer Prevention Research

LIN28B Promotes Colon Cancer Progression and Metastasis

(2011) C. E. King et al.   CANCER RESEARCH

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer

(2011) Qiang Lu   Molecular Medicine Reports

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer

(2011) Cheng-Chia Yu   ONCOLOGY REPORTS

MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation

(2011) Cheng-Chia Yu et al.   ORAL ONCOLOGY

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis

(2010) Junfang Ji et al.   JOURNAL OF HEPATOLOGY

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

(2010) Collin Melton et al.   NATURE

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

(2010) Hao Zhu et al.   NATURE GENETICS

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells

(2009) Sugiko Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype

(2009) G Grelier et al.   BRITISH JOURNAL OF CANCER

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

H19 acts as a trans regulator of the imprinted gene network controlling growth in mice

(2009) A. Gabory et al.   DEVELOPMENT

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

(2008) M. A. Newman et al.   RNA

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE