The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let‐7i/TET3 pathway

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression

(2019) Seisuke Yamashita et al.   Nature Communications

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer

(2019) Sahar Nissim et al.   NATURE GENETICS

ROS/KRAS/AMPK Signaling Contributes to Gemcitabine-Induced Stem-like Cell Properties in Pancreatic Cancer

(2019) Hengqiang Zhao et al.   Molecular Therapy-Oncolytics

A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

(2019) Shigekazu Murakami et al.   DEVELOPMENTAL CELL

The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition

(2019) Cristina Oliveira-Mateos et al.   Nature Communications

LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway

(2018) Meiting Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs

(2018) Dmytro Ustianenko et al.   MOLECULAR CELL

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

(2018) Silvia Ottaviani et al.   Nature Communications

The evolving concept of liver cancer stem cells

(2017) Kouki Nio et al.   Molecular Cancer

Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention

(2017) Claudia Gasch et al.   Molecular Cancer

TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells

(2017) Nipun Verma et al.   NATURE GENETICS

Molecular genetics and cellular events of K-Ras-driven tumorigenesis

(2017) G G Jinesh et al.   ONCOGENE

Survival of pancreatic cancer cells lacking KRAS function

(2017) Mandar Deepak Muzumdar et al.   Nature Communications

Activation of the Lin28/let-7 Axis by Loss of ESE3/EHF Promotes a Tumorigenic and Stem-like Phenotype in Prostate Cancer

(2016) D. Albino et al.   CANCER RESEARCH

SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b

(2016) Sita Kugel et al.   CELL

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

(2016) Maria Anna Zipeto et al.   Cell Stem Cell

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

(2016) Jin Zhang et al.   Cell Stem Cell

Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

(2016) Yasuo Takashima et al.   HEPATOLOGY

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma

(2016) John T. Powers et al.   NATURE

Novel PKC-ζ to p47phox interaction is necessary for transformation from blebbishields

(2016) Goodwin G. Jinesh et al.   Scientific Reports

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

(2015) Man-Tzu Wang et al.   CELL

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

(2015) Jean-Pierre Etchegaray et al.   NATURE CELL BIOLOGY

Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells

(2015) Faith A. Bazley et al.   STEM CELLS AND DEVELOPMENT

Novel signaling axis for ROS generation during K-Ras-induced cellular transformation

(2014) M-T Park et al.   CELL DEATH AND DIFFERENTIATION

Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells

(2014) Carles Barceló et al.   GASTROENTEROLOGY

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

(2013) K S Hill et al.   ONCOGENE

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

(2013) X. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lin28-let7 Modulates Radiosensitivity of Human Cancer Cells With Activation of K-Ras

(2009) Jee-Sun Oh et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS