Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells

AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells

(2012) D. Zhang et al.   GENES & DEVELOPMENT

LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance

(2012) Melissa L. Wilbert et al.   MOLECULAR CELL

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

eIF5A isoforms and cancer: two brothers for two functions?

(2011) M. Caraglia et al.   AMINO ACIDS

Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma

(2011) J Buechner et al.   BRITISH JOURNAL OF CANCER

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Overexpression of HMGA2 Promotes Metastasis and Impacts Survival of Colorectal Cancers

(2011) X. Wang et al.   CLINICAL CANCER RESEARCH

Silencing of microRNA families by seed-targeting tiny LNAs

(2011) Susanna Obad et al.   NATURE GENETICS

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Cancer Chemoprevention Locks onto a New Polyamine Metabolic Target

(2010) E. W. Gerner   Cancer Prevention Research

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Skin Cancer Prevention Study of  -Difluoromethylornithine in Subjects with Previous History of Skin Cancer

(2010) H. H. Bailey et al.   Cancer Prevention Research

Lin28: A MicroRNA Regulator with a Macro Role

(2010) Srinivas R. Viswanathan et al.   CELL

The Role of Polyamines in Supporting Growth of Mammalian Cells Is Mediated through Their Requirement for Translation Initiation and Elongation

(2010) Guy Landau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The early history of polyamine research

(2010) Uriel Bachrach   PLANT PHYSIOLOGY AND BIOCHEMISTRY

eIF5A has a function in the elongation step of translation in yeast

(2009) Ana P.B. Gregio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting Ornithine Decarboxylase Impairs Development of MYCN-Amplified Neuroblastoma

(2009) R. J. Rounbehler et al.   CANCER RESEARCH

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Disrupting Polyamine Homeostasis as a Therapeutic Strategy for Neuroblastoma

(2009) N. F. Evageliou et al.   CLINICAL CANCER RESEARCH

Regulation by c-Myc of ncRNA expression

(2009) Niall S Kenneth et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

(2009) T.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S Ribosome

(2009) G. Blaha et al.   SCIENCE

The Effect of Difluoromethylornithine on Decreasing Prostate Size and Polyamines in Men: Results of a Year-Long Phase IIb Randomized Placebo-Controlled Chemoprevention Trial

(2008) A. R. Simoneau et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

(2008) Frank L. Meyskens et al.   Cancer Prevention Research

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine

(2008) M. K. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY