Matrine suppression of self‐renewal was dependent on regulation of LIN28A/Let‐7 pathway in breast cancer stem cells

Chinese herbal extract Su-duxing had potent inhibitory effects on both wild-type and entecavir-resistant hepatitis B virus (HBV) in vitro and effectively suppressed HBV replication in mouse model

(2018) Yan Liu et al.   ANTIVIRAL RESEARCH

CCAT1 stimulation of the symmetric division of NSCLC stem cells through activation of the Wnt signalling cascade

(2018) C Xu et al.   GENE THERAPY

Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway

(2018) Bing-Gang Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation

(2018) Li Gao et al.   Scientific Reports

Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1

(2018) Huizhen Fan et al.   Journal of Immunology Research

H19 regulation of oestrogen induction of symmetric division is achieved by antagonizing Let-7c in breast cancer stem-like cells

(2018) Meng Wang et al.   CELL PROLIFERATION

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy

(2018) Bingtao Zhai et al.   International Journal of Nanomedicine

Downregulation of microRNA‐367 promotes osteoblasts growth and proliferation of mice during fracture by activating the PANX3‐mediated Wnt/β‐catenin pathway

(2018) Hong‐Lei Jia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interplay between microRNAs and Wnt, transforming growth factor‐β, and bone morphogenic protein signaling pathways promote osteoblastic differentiation of mesenchymal stem cells

(2018) Somayeh Aslani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway

(2018) Yanxia Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling

(2018) Jiayi Wu et al.   JOURNAL OF HEPATOLOGY

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis

(2018) Debadrita Bhattacharya et al.   eLife

Nano Let-7b sensitization of eliminating esophageal cancer stem-like cells is dependent on blockade of Wnt activation of symmetric division

(2017) Yamei Pang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Synthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells

(2017) Lei Zhang et al.   MOLECULES

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Matrine Suppresses the ER-positive MCF Cells by Regulating Energy Metabolism and Endoplasmic Reticulum Stress Signaling Pathway

(2017) Yi Xiao et al.   PHYTOTHERAPY RESEARCH

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

(2017) Joseph L. Regan et al.   Cell Reports

Ursolic acid benzaldehyde chalcone, leads to inhibition of cell proliferation and arrests cycle in G1/G0 phase in colon cancer

(2017) Xinying Zhuang et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents

(2016) Lichuan Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells

(2016) X Sun et al.   CANCER GENE THERAPY

The Wnt signaling pathway in cancer

(2016) Yann Duchartre et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia

(2016) S. S. Y. Lam et al.   Science Translational Medicine

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

(2016) Chen-Xu Ni et al.   Oncotarget

Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents

(2016) Lichuan Wu et al.   Scientific Reports

Effect of Matrine on HPAC cell migration by down-regulating the expression of MT1-MMP via Wnt signaling

(2015) Yongchao Ma et al.   Cancer Cell International

DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1

(2015) Xin Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

(2015) Ken-ichi Fujita   WORLD JOURNAL OF GASTROENTEROLOGY

Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells

(2014) Bingyu Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Breast cancer in China

(2014) Lei Fan et al.   LANCET ONCOLOGY

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors

(2014) Alexandre Desjardins et al.   NUCLEIC ACIDS RESEARCH

The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain

(2014) Yuhong Zhou et al.   PHYTOMEDICINE

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs

(2012) Inha Heo et al.   CELL

Lin-28 Homologue A (LIN28A) Promotes Cell Cycle Progression via Regulation of Cyclin-dependent Kinase 2 (CDK2), Cyclin D1 (CCND1), and Cell Division Cycle 25 Homolog A (CDC25A) Expression in Cancer

(2012) Ning Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

(2011) Elena Piskounova et al.   CELL

Phase II Study of the Halichondrin B Analog Eribulin Mesylate in Patients With Locally Advanced or Metastatic Breast Cancer Previously Treated With an Anthracycline, a Taxane, and Capecitabine

(2010) Javier Cortes et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Study of Eribulin Mesylate, a Halichondrin B Analog, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

(2009) Linda T. Vahdat et al.   JOURNAL OF CLINICAL ONCOLOGY