The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines

A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth

(2013) T. Lau et al.   CANCER RESEARCH

Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor

(2013) Andrew Voronkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Wnt Pathway in Synovial Sarcoma Models

(2013) W. Barham et al.   Cancer Discovery

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Clinical Outcome Prediction by MicroRNAs in Human Cancer: A Systematic Review

(2012) Viswam S. Nair et al.   JNCI-Journal of the National Cancer Institute

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

(2012) Richard G. James et al.   PLoS One

Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma

(2012) Stine H. Kresse et al.   PLoS One

Wnt Signaling in Vertebrate Axis Specification

(2012) H. Hikasa et al.   Cold Spring Harbor Perspectives in Biology

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

(2012) Timothy A. Blauwkamp et al.   Nature Communications

Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth

(2011) J. Waaler et al.   CANCER RESEARCH

The Wnt signaling pathway: implications for therapy in osteosarcoma

(2011) Peter McQueen et al.   Expert Review of Anticancer Therapy

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

(2011) Alexander B Mohseny et al.   LABORATORY INVESTIGATION

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas

(2011) U Basu-Roy et al.   ONCOGENE

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Thelet-7microRNA reduces tumor growth in mouse models of lung cancer

(2010) Aurora Esquela-Kerscher et al.   CELL CYCLE

Synergistic Antitumor Effect of the Activated PPAR  and Retinoid Receptors on Human Osteosarcoma

(2010) B. C. He et al.   CLINICAL CANCER RESEARCH

MicroRNA roles in beta-catenin pathway

(2010) Kai Huang et al.   Molecular Cancer

Wnt Inhibitory Factor 1 Decreases Tumorigenesis and Metastasis in Osteosarcoma

(2010) E. M. Rubin et al.   MOLECULAR CANCER THERAPEUTICS

IGF-I activates caspases 3/7, 8 and 9 but does not induce cell death in colorectal cancer cells

(2009) Shi Yu Yang et al.   BMC CANCER

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The role of let-7 in cell differentiation and cancer

(2009) Benjamin Boyerinas et al.   ENDOCRINE-RELATED CANCER

PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders?

(2009) Nicola et al.   Frontiers in Bioscience-Landmark

Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effort

(2009) Laura Ottaviano et al.   GENES CHROMOSOMES & CANCER

Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

(2009) Maya Kansara et al.   JOURNAL OF CLINICAL INVESTIGATION

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Osteosarcoma Development and Stem Cell Differentiation

(2008) Ni Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects

(2008) Xiaoji Luo et al.   LABORATORY INVESTIGATION