TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis

TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine

(2021) Yang Emma Li et al.   JOURNAL OF CELL BIOLOGY

A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis

(2021) Alireza Ghanbarpour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids and Lipoproteins in 2020

(2020) Brian A. Ference et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetically encoded tags for direct synthesis of EM-visible gold nanoparticles in cells

(2020) Zhaodi Jiang et al.   NATURE METHODS

TMEM16K is an interorganelle regulator of endosomal sorting

(2020) Maja Petkovic et al.   Nature Communications

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

(2020) William M. Schneider et al.   CELL

TMEM41B Is a Pan-flavivirus Host Factor

(2020) H.-Heinrich Hoffmann et al.   CELL

Click-ExM enables expansion microscopy for all biomolecules

(2020) De-en Sun et al.   NATURE METHODS

Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans

(2020) Xiao Wang et al.   Cell Metabolism

The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum

(2019) G. Elif Karagöz et al.   Cold Spring Harbor Perspectives in Biology

TMEM41B functions with VMP1 in autophagosome formation

(2019) Keigo Morita et al.   Autophagy

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

(2019) Christopher J. Shoemaker et al.   PLOS BIOLOGY

Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution

(2019) Takuma Tsuji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role of VMP1 in lipoprotein secretion

(2019) Hideaki Morishita et al.   eLife

Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis

(2019) Ji-Yeon Shin et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of glucose and lipid metabolism in health and disease

(2019) Ligong Chen et al.   Science China-Life Sciences

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

(2019) Simon R. Bushell et al.   Nature Communications

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy

(2018) Xiang Cheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Dimeric sorting code for concentrative cargo selection by the COPII coat

(2018) Chao Nie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

(2018) Ju Youn Kim et al.   CELL

TMEM41B is a novel regulator of autophagy and lipid mobilization

(2018) Francesca Moretti et al.   EMBO REPORTS

Genome-wide CRISPR screen identifiesTMEM41Bas a gene required for autophagosome formation

(2018) Keigo Morita et al.   JOURNAL OF CELL BIOLOGY

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

(2018) Xuchu Que et al.   NATURE

Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys

(2018) Wen Zheng et al.   Diabetology & Metabolic Syndrome

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping

(2016) Thomas Günther Pomorski et al.   PROGRESS IN LIPID RESEARCH

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Intracellular Trafficking and Secretion of VLDL

(2012) Samata Tiwari et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vesicle-mediated ER export of proteins and lipids

(2012) Amanda D. Gillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Microsome-associated lumenal lipid droplets in the regulation of lipoprotein secretion

(2012) Zemin Yao et al.   CURRENT OPINION IN LIPIDOLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

(2008) Michael S. Brown et al.   JOURNAL OF LIPID RESEARCH

The many intersecting pathways underlying apolipoprotein B secretion and degradation

(2008) Jeffrey L. Brodsky et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM