Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

(2021) Charles Arber et al.   Cell Reports

Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients

(2020) Aaron M. Cook et al.   Neurocritical Care

Vascularized human cortical organoids (vOrganoids) model cortical development in vivo

(2020) Yingchao Shi et al.   PLOS BIOLOGY

Human CNS barrier-forming organoids with cerebrospinal fluid production

(2020) Laura Pellegrini et al.   SCIENCE

Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

(2020) Takahiro Kitahara et al.   Stem Cell Reports

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

Human cerebral organoids establish subcortical projections in the mouse brain after transplantation

(2020) Xin Dong et al.   MOLECULAR PSYCHIATRY

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids

(2019) Yangfei Xiang et al.   Cell Stem Cell

Self-management of heart failure in dementia and cognitive impairment: a systematic review

(2019) Janaka Lovell et al.   BMC Cardiovascular Disorders

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

(2019) Charles Arber et al.   MOLECULAR PSYCHIATRY

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

(2019) Liqing Song et al.   Scientific Reports

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Cerebral organoids: ethical issues and consciousness assessment

(2018) Andrea Lavazza et al.   JOURNAL OF MEDICAL ETHICS

Modeling Alzheimer's Disease: Insights from In vivo to In vitro 3D Culture Platforms

(2018) Vivek Damodar Ranjan et al.   Journal of Tissue Engineering and Regenerative Medicine

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

(2018) Tao Yang et al.   Nature Reviews Nephrology

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells

(2018) Takenori Ogura et al.   DEVELOPMENT

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer’s Disease

(2018) Neha Atulkumar Singh et al.   Frontiers in Aging Neuroscience

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

(2018) Serena Pavoni et al.   PLoS One

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Long non-coding RNA HOXA-AS2 promotes the migration, invasion and stemness of bladder cancer via regulating miR-125b/Smad2 axis

(2018) Fei Wang et al.   EXPERIMENTAL CELL RESEARCH

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer’s disease (PSEN1-A246E) induced pluripotent stem cells

(2017) Enrique Armijo et al.   NEUROSCIENCE LETTERS

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2Novelty and Significance

(2016) Sangho Lee et al.   CIRCULATION RESEARCH

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

The road to precision psychiatry: translating genetics into disease mechanisms

(2016) Michael J Gandal et al.   NATURE NEUROSCIENCE

Dementia risk in renal dysfunction

(2016) Kay Deckers et al.   NEUROLOGY

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Alzheimer's in 3D culture: Challenges and perspectives

(2015) Carla D'Avanzo et al.   BIOESSAYS

Involvement of Bone Marrow Cells and Neuroinflammation in HypertensionNovelty and Significance

(2015) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

(2015) Steven Moore et al.   Cell Reports

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

(2015) Claudia Balducci et al.   CURRENT PHARMACEUTICAL DESIGN

Microfluidic techniques for development of 3D vascularized tissue

(2014) Anwarul Hasan et al.   BIOMATERIALS

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

3D Cell Culture Systems: Advantages and Applications

(2014) Maddaly Ravi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

(2014) Vasiliki Mahairaki et al.   STEM CELLS AND DEVELOPMENT

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis

(2013) J.-M. Bugnicourt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin

(2013) Melita Salkovic-Petrisic et al.   NEUROPHARMACOLOGY

Chronic Kidney Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis

(2012) Thorleif Etgen et al.   AMERICAN JOURNAL OF NEPHROLOGY

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Cognitive Impairment in Heart Failure Patients

(2012) R. Burke et al.   Heart Lung and Circulation

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

(2012) Diana Seidel et al.   PLoS One

Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction

(2011) Anouk G.W. van Norden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modeling psychiatric disorders through reprogramming

(2011) K. J. Brennand et al.   Disease Models & Mechanisms

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Guanidino Compounds as Uremic (Neuro)Toxins

(2009) Peter Paul De Deyn et al.   SEMINARS IN DIALYSIS

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Structural and functional biomarkers of prodromal Alzheimer's disease: A high-dimensional pattern classification study

(2008) Yong Fan et al.   NEUROIMAGE

Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

(2008) T. Wataya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA