Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

Inhibition of PHF-like Tau Hyperphosphorylation in SH-SY5Y Cells and Rat Brain Slices by K252a

(2017) Gabriele Hübinger et al.   JOURNAL OF ALZHEIMERS DISEASE

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates

(2012) Tina Löffler et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peering inside Alzheimer's brains

(2011) Gunjan Sinha   NATURE BIOTECHNOLOGY

Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice

(2011) María-Ximena Silveyra et al.   NEUROBIOLOGY OF AGING

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring

(2010) Dana Krinke et al.   BIOSENSORS & BIOELECTRONICS

Modulation of Tau Phosphorylation by the Kinase PKR: Implications in Alzheimer's Disease

(2010) Anindita Bose et al.   BRAIN PATHOLOGY

An okadaic acid-induced model of tauopathy and cognitive deficiency

(2010) Zhang Zhang et al.   BRAIN RESEARCH

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspases first

(2010) Jesús Avila   Nature Reviews Neurology

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and Dysfunction

(2010) Mariangela Iovino et al.   PLoS One

Animal models reveal role for tau phosphorylation in human disease

(2009) Jürgen Götz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes

(2009) Dana Krinke et al.   BIOSENSORS & BIOELECTRONICS

β-Secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

(2009) Xue-Mei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tau-directed drug discovery for Alzheimer's disease and related tauopathies: A focus on tau assembly inhibitors

(2009) Kurt R. Brunden et al.   EXPERIMENTAL NEUROLOGY

Challenges in the conduct of disease-modifying trials in ad: Practical experience from a phase 2 trial of TAU-aggregation inhibitor therapy

(2009) C. Wischik et al.   Journal of Nutrition Health & Aging

An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells

(2009) Heinz-Georg Jahnke et al.   LAB ON A CHIP

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models

(2008) Daniel Kloß et al.   BIOSENSORS & BIOELECTRONICS

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY

β-adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells

(2008) Maya Mikami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation

(2008) Ina Hinners et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction

(2008) Geneviève Leuba et al.   NEUROBIOLOGY OF DISEASE

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE