Familial Alzheimer’s Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

(2019) Katharina Meyer et al.   Cell Reports

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

(2019) Daniel A. Berg et al.   CELL

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

(2019) Charles Arber et al.   MOLECULAR PSYCHIATRY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

Human Hippocampal Neurogenesis Persists throughout Aging

(2018) Maura Boldrini et al.   Cell Stem Cell

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

(2018) Shawn F. Sorrells et al.   NATURE

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

(2018) Hannah Hochgerner et al.   NATURE NEUROSCIENCE

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

(2018) Alexandria N. Tartt et al.   Cell Stem Cell

Does Adult Neurogenesis Persist in the Human Hippocampus?

(2018) Mercedes F. Paredes et al.   Cell Stem Cell

Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus

(2017) Carmela Gómez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing

(2017) Swananda Marathe et al.   Frontiers in Cellular Neuroscience

Taming Human Genetic Variability: Transcriptomic Meta-Analysis Guides the Experimental Design and Interpretation of iPSC-Based Disease Modeling

(2017) Pierre-Luc Germain et al.   Stem Cell Reports

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series

(2016) Natalie S Ryan et al.   LANCET NEUROLOGY

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease

(2016) M. S. Unger et al.   MOLECULAR NEUROBIOLOGY

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

(2016) Arun Kumar Somavarapu et al.   NEUROBIOLOGY OF DISEASE

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

(2016) Juan Yang et al.   Oncotarget

Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease

(2016) Emanuele Brai et al.   Acta Neuropathologica Communications

Preserved neurogenesis in non-demented individuals with AD neuropathology

(2016) David Briley et al.   Scientific Reports

Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation

(2016) Petra Bergström et al.   Scientific Reports

Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of  -Secretase

(2015) S. Takagi-Niidome et al.   JOURNAL OF NEUROSCIENCE

Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors

(2015) Reuven Edri et al.   Nature Communications

Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease

(2015) Yakeel T. Quiroz et al.   JAMA Neurology

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory

(2015) Jacqueline A. Bonds et al.   PLoS One

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Cognitive Deficits and Disruption of Neurogenesis in a Mouse Model of Apolipoprotein E4 Domain Interaction

(2013) Samuel O. Adeosun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Notch Signaling Maintains Neural Rosette Polarity

(2013) Heather Main et al.   PLoS One

Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease

(2013) Douglas C. Dean et al.   JAMA Neurology

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

ApoE is required for maintenance of the dentate gyrus neural progenitor pool

(2011) C.-P. Yang et al.   DEVELOPMENT

Adult hippocampal neurogenesis in aging and Alzheimer's disease

(2010) Lorena Varela-Nallar et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease

(2010) Laura K. Hamilton et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Increased BMP6 Levels in the Brains of Alzheimer's Disease Patients and APP Transgenic Mice Are Accompanied by Impaired Neurogenesis

(2010) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells

(2009) Sun-Mi Woo et al.   BMC NEUROSCIENCE

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis

(2008) Quan-Hong Ma et al.   NATURE CELL BIOLOGY

Early age-related changes in adult hippocampal neurogenesis in C57 mice

(2008) Nada M.-B. Ben Abdallah et al.   NEUROBIOLOGY OF AGING

Adult neurogenesis is functionally associated with AD-like neurodegeneration

(2007) Qian Chen et al.   NEUROBIOLOGY OF DISEASE