The Role of Neuroinflammation in Post-traumatic Epilepsy

Microglial polarization in posttraumatic epilepsy: Potential mechanism and treatment opportunity

(2020) Peravina Therajaran et al.   EPILEPSIA

Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Ettore Beghi et al.   LANCET NEUROLOGY

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model

(2019) Marson Putra et al.   NEUROBIOLOGY OF DISEASE

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade

(2018) Allen D. DeSena et al.   Journal of Neuroinflammation

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

(2018) Si-Qiang Ren et al.   Scientific Reports

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

(2017) Pavel Klein et al.   EPILEPSIA

Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet

(2017) Gaetano Terrone et al.   EPILEPSIA

Inflammation in epileptogenesis after traumatic brain injury

(2017) Kyria M. Webster et al.   Journal of Neuroinflammation

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain

(2017) Bridgette D. Semple et al.   JOURNAL OF NEUROSCIENCE

Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy

(2017) Shaunik Sharma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

(2017) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation

(2017) Sarah C. Konefal et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pathophysiology of Traumatic Brain Injury

(2017) Kirsty J. Dixon   Physical Medicine and Rehabilitation Clinics of North America

NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility

(2016) Fushun Wang et al.   Brain Structure & Function

Astrocyte roles in traumatic brain injury

(2016) Joshua E. Burda et al.   EXPERIMENTAL NEUROLOGY

The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation

(2016) Chiara Cerri et al.   JOURNAL OF NEUROSCIENCE

Glia as drivers of abnormal neuronal activity

(2016) Stefanie Robel et al.   NATURE NEUROSCIENCE

Epilepsy, amyloid-β, and D1 dopamine receptors: a possible pathogenetic link?

(2016) Cinzia Costa et al.   NEUROBIOLOGY OF AGING

1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy

(2016) Sreekanth Puttachary et al.   NEUROBIOLOGY OF DISEASE

ATPergic signalling during seizures and epilepsy

(2016) Tobias Engel et al.   NEUROPHARMACOLOGY

Inflammatory mediators in human epilepsy: A systematic review and meta-analysis

(2016) Evelien E. de Vries et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome

(2016) Nicole Reams et al.   JAMA Neurology

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

(2015) Melissa J. Benson et al.   EPILEPSIA

IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study

(2015) Matthew L. Diamond et al.   EPILEPSIA

The pathogenic role of the inflammasome in neurodegenerative diseases

(2015) Leslie C. Freeman et al.   JOURNAL OF NEUROCHEMISTRY

Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury

(2015) Stefka Gyoneva et al.   Journal of Neuroinflammation

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling

(2015) M. L. Olsen et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Traumatic brain injury and epilepsy: Underlying mechanisms leading to seizure

(2015) Brandon P. Lucke-Wold et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Immediate, early and late seizures after primary intracerebral hemorrhage

(2014) Cheng Qian et al.   EPILEPSY RESEARCH

Repeated Mild Traumatic Brain Injury Causes Chronic Neuroinflammation, Changes in Hippocampal Synaptic Plasticity, and Associated Cognitive Deficits

(2014) Stephanie L Aungst et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Network dysfunction after traumatic brain injury

(2014) David J. Sharp et al.   Nature Reviews Neurology

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain

(2013) Young Se Kwon et al.   Journal of Neuroinflammation

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Hyperphosphorylated Tau is Implicated in Acquired Epilepsy and Neuropsychiatric Comorbidities

(2013) Ping Zheng et al.   MOLECULAR NEUROBIOLOGY

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers

(2013) Steven T. DeKosky et al.   Nature Reviews Neurology

The Role of Markers of Inflammation in Traumatic Brain Injury

(2013) Thomas Woodcock et al.   Frontiers in Neurology

Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling

(2012) Oliver Braganza et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)

(2012) Meir Bialer et al.   EPILEPSY RESEARCH

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

(2012) Stephanie Adamczak et al.   JOURNAL OF NEUROSURGERY

Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury

(2012) Tie-Lei Gao et al.   Journal of Trauma and Acute Care Surgery

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

Oxidative Stress and Epilepsy: Literature Review

(2012) Carlos Clayton Torres Aguiar et al.   Oxidative Medicine and Cellular Longevity

Clinical epidemiology of posttraumatic epilepsy in a group of Chinese patients

(2012) Yongqing Zhao et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy

(2012) M. Nowak et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

A perfect storm: Converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation

(2011) Jeffrey Noebels   EPILEPSIA

Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

(2011) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Interleukin-1  and HMGB1 Mediate Hippocampal Dysfunction in SIGIRR-Deficient Mice

(2011) D. A. Costello et al.   JOURNAL OF NEUROSCIENCE

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice

(2010) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Blockade of Acute Microglial Activation by Minocycline Promotes Neuroprotection and Reduces Locomotor Hyperactivity after Closed Head Injury in Mice: A Twelve-Week Follow-Up Study

(2010) Shadi Homsi et al.   JOURNAL OF NEUROTRAUMA

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

(2009) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Transcriptome Profiling Reveals TGF-  Signaling Involvement in Epileptogenesis

(2009) L. P. Cacheaux et al.   JOURNAL OF NEUROSCIENCE

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury

(2009) Tony Frugier et al.   JOURNAL OF NEUROTRAUMA

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Interleukin-10 is associated with resistance to febrile seizures: Genetic association and experimental animal studies

(2008) Yoshito Ishizaki et al.   EPILEPSIA

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Blood-brain barrier disruption in post-traumatic epilepsy

(2007) O Tomkins et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY