miR-181a-regulated pathways in T-cell differentiation and aging

Hallmarks of the aging T‐cell system

(2021) Huimin Zhang et al.   FEBS Journal

Influence of immune aging on vaccine responses

(2020) Claire E. Gustafson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation

(2020) Wenqiang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells

(2020) Clarice X. Lim et al.   Cell Reports

B Cell Immunosenescence

(2020) Daniela Frasca et al.   Annual Review of Cell and Developmental Biology

MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function

(2020) Zoe Grewers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Transcription Factor TCF1 in T Cell Differentiation and Aging

(2020) Chulwoo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity

(2019) Marcin Łyszkiewicz et al.   PLOS BIOLOGY

Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation

(2019) Bin Hu et al.   AGING CELL

Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD+–SIRT1 pathway

(2019) Rui Ma et al.   NUCLEIC ACIDS RESEARCH

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

(2019) Chulwoo Kim et al.   Cell Reports

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

(2019) Dinesh Raghu et al.   TRENDS IN IMMUNOLOGY

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Epigenetics of T cell aging

(2018) Jörg J. Goronzy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of miR-181a expression in T cell aging

(2018) Zhongde Ye et al.   Nature Communications

Functional pathways regulated by microRNA networks in CD8 T-cell aging

(2018) Claire E. Gustafson et al.   AGING CELL

MicroRNA miR-181a/b-1 controls MAIT cell development

(2018) Samantha J Winter et al.   IMMUNOLOGY AND CELL BIOLOGY

Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

(2018) Chulwoo Kim et al.   Cell Reports

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate

(2017) Veena Krishnamoorthy et al.   IMMUNITY

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

(2016) Soo Seok Hwang et al.   Nature Communications

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

(2016) Fengqin Fang et al.   Cell Reports

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

(2016) Qian Qi et al.   PLoS Pathogens

Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome

(2016) Eddie A. James et al.   PLoS Pathogens

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hepatitis C virus-induced reduction in miR-181a impairs CD4+T-cell responses through overexpression of DUSP6

(2015) Guang Y. Li et al.   HEPATOLOGY

mir-181a-1/b-1Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function

(2015) Steven A. Schaffert et al.   JOURNAL OF IMMUNOLOGY

Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans

(2015) Axel Ronald Schulz et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development

(2015) Inga Sandrock et al.   PLoS One

TCR Signaling in T Cell Memory

(2015) Mark A. Daniels et al.   Frontiers in Immunology

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

(2015) Chan C. Whiting et al.   PLoS One

miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway

(2014) Zhonghua Wei et al.   FEBS LETTERS

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated mice

(2014) HUAN GONG et al.   Molecular Medicine Reports

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

(2013) Jorge Henao-Mejia et al.   IMMUNITY

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

New histone supply regulates replication fork speed and PCNA unloading

(2013) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a

(2013) A. C. Palin et al.   JOURNAL OF IMMUNOLOGY

The Quadrivalent Approach to Influenza Vaccination

(2013) R. Dolin   JOURNAL OF INFECTIOUS DISEASES

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression

(2013) Dirk Baumjohann et al.   NATURE IMMUNOLOGY

miR-181a Regulates Inflammation Responses in Monocytes and Macrophages

(2013) Weidong Xie et al.   PLoS One

Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

(2013) N. Zietara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

(2012) B. Zhou et al.   DIABETOLOGIA

miR-146acontrols the resolution of T cell responses in mice

(2012) Lili Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling

(2012) Michael P Seiler et al.   NATURE IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation

(2012) S. S. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation

(2012) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

(2012) Rita Fragoso et al.   PLoS Genetics

Increased apoptosis, curtailed expansion and incomplete differentiation of CD8+ T cells combine to decrease clearance of L. monocytogenes in old mice

(2011) Megan J. Smithey et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A critical role for TCF-1 in T-lineage specification and differentiation

(2011) Brittany Nicole Weber et al.   NATURE

CBP/p300 and SIRT1 Are Involved in Transcriptional Regulation of S-Phase Specific Histone Genes

(2011) Hongpeng He et al.   PLoS One

Elderly Subjects Have a Delayed Antibody Response and Prolonged Viraemia following Yellow Fever Vaccination: A Prospective Controlled Cohort Study

(2011) Anna H. Roukens et al.   PLoS One

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

(2010) Matthias Hackl et al.   AGING CELL

Nature and nurture: T-cell receptor-dependent and T-cell receptor-independent differentiation cues in the selection of the memory T-cell pool

(2010) Chulwoo Kim et al.   IMMUNOLOGY

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Dicer controls CD8+ T-cell activation, migration, and survival

(2010) N. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key role of T cell defects in age-related vulnerability to West Nile virus

(2009) James D. Brien et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Randomized, Double‐Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High‐Dose and Standard‐Dose Influenza Vaccine in Adults 65 Years of Age and Older

(2009) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

(2008) William F. Marzluff et al.   NATURE REVIEWS GENETICS

Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

(2008) Gwen Liu et al.   PLoS One