Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT–NAD+–SIRT1 pathway

Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span

(2019) Qianyun Mei et al.   NUCLEIC ACIDS RESEARCH

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

(2019) Joshua J. Gruber et al.   MOLECULAR CELL

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling

(2018) Pengli Zheng et al.   CELL RESEARCH

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals

(2018) Xiaojing Liu et al.   CELL

Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer

(2018) Xilan Yu et al.   Frontiers in Genetics

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

(2018) Takayuki Nojima et al.   MOLECULAR CELL

Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models

(2017) I. Popova et al.   NEUROBIOLOGY OF DISEASE

Epigenetic Regulatory Mechanisms Induced by Resveratrol

(2017) Guilherme Fernandes et al.   Nutrients

Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites

(2017) Qi Yu et al.   PLoS One

Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential

(2016) J. George et al.   CANCER RESEARCH

Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae

(2016) Emily L. Petty et al.   GENETICS

SirT1 activator represses the transcription of TNF-α in THP-1 cells of a sepsis model via deacetylation of H4K16

(2016) Guo-Dong Chen et al.   Molecular Medicine Reports

Non-metabolic functions of glycolytic enzymes in tumorigenesis

(2016) X Yu et al.   ONCOGENE

Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species

(2016) Lorena Aguilar-Arnal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma

(2016) Amit D. Gujar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies

(2016) Kristofor A. Olson et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate

(2016) Chengqian Yin et al.   Oncotarget

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

(2016) Candice Sun Hong et al.   Cell Reports

Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae

(2016) Emily L. Petty et al.   GENETICS

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3

(2015) Pankaj K. Bagul et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism

(2015) Shanshan Li et al.   MOLECULAR CELL

HDAC Inhibitor Sodium Butyrate Augments the MEF2C Enhancement of Nampt Expression under Hypoxia

(2014) Shao-Fei Yan et al.   CURRENT PHARMACEUTICAL DESIGN

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pyruvate as a Pivot Point for Oncogene-Induced Senescence

(2013) Benjamin A. Olenchock et al.   CELL

Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

(2013) Min-Xian Qian et al.   CELL

Regulation of pyruvate metabolism in metabolic-related diseases

(2013) Nam Ho Jeoung et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma

(2011) S. Saarinen et al.   BLOOD

SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor   in Breast Cancer

(2011) S. Elangovan et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes

(2009) Chiao-Po Hsu et al.   Autophagy

Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX

(2009) Kazutsune Yamagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

(2009) Tong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA

(2009) R. Magnus N. Friis et al.   NUCLEIC ACIDS RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

(2008) L De Boer et al.   ONCOGENE

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

(2008) Rea Biacsi et al.   PLoS Genetics