MicroRNA miR-181—A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation

(2020) Tiago Amado et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A focus on natural killer T‐cell subset characterization and developmental stages

(2020) Jihene Klibi et al.   IMMUNOLOGY AND CELL BIOLOGY

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer

(2020) Alessia Indrieri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thymic regulatory T cells arise via two distinct developmental programs

(2019) David L. Owen et al.   NATURE IMMUNOLOGY

miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity

(2019) Marcin Łyszkiewicz et al.   PLOS BIOLOGY

SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection

(2019) Yan Lu et al.   NATURE IMMUNOLOGY

MicroRNA-managing the development of MAIT cells

(2019) Hui-Fern Koay et al.   IMMUNOLOGY AND CELL BIOLOGY

Chronically stimulated human MAIT cells are unexpectedly potent IL‐13 producers

(2019) Jason Kelly et al.   IMMUNOLOGY AND CELL BIOLOGY

Molecular mechanisms of lineage decisions in metabolite-specific T cells

(2019) François Legoux et al.   NATURE IMMUNOLOGY

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

(2019) François Legoux et al.   SCIENCE

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat

(2019) Verena Labi et al.   GENES & DEVELOPMENT

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

CD45 functions as a signaling gatekeeper in T cells

(2019) Adam H. Courtney et al.   Science Signaling

Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

(2019) Chulwoo Kim et al.   Cell Reports

Development of Unconventional T Cells Controlled by MicroRNA

(2019) Samantha J. Winter et al.   Frontiers in Immunology

The biochemical basis of microRNA targeting efficacy

(2019) Sean E. McGeary et al.   SCIENCE

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

(2018) Isabelle Serr et al.   Science Translational Medicine

TCR signal strength controls thymic differentiation of iNKT cell subsets

(2018) Kathryn D. Tuttle et al.   Nature Communications

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

(2018) Jing-Ping Hsin et al.   NATURE IMMUNOLOGY

MicroRNA miR-181a/b-1 controls MAIT cell development

(2018) Samantha J Winter et al.   IMMUNOLOGY AND CELL BIOLOGY

A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets

(2018) Marion Salou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Themis-associated phosphatase activity controls signaling in T cell development

(2018) Monika Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THEMIS: Two Models, Different Thresholds

(2017) Seeyoung Choi et al.   TRENDS IN IMMUNOLOGY

Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection

(2016) Ryan J. Martinez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Overexpression of Vα14Jα18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1

(2016) Jonas Blume et al.   IMMUNOLOGY AND CELL BIOLOGY

miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation

(2016) Chun-Wei Lee et al.   JOURNAL OF IMMUNOLOGY

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

(2015) Li-Fan Lu et al.   IMMUNITY

mir-181a-1/b-1Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function

(2015) Steven A. Schaffert et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development

(2015) Inga Sandrock et al.   PLoS One

The Functions of MicroRNAs: mRNA Decay and Translational Repression

(2015) Hiro-oki Iwakawa et al.   TRENDS IN CELL BIOLOGY

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Differential Requirement for IL-2 and IL-15 during Bifurcated Development of Thymic Regulatory T Cells

(2014) Daniel Marshall et al.   JOURNAL OF IMMUNOLOGY

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

(2014) Kristin A Hogquist et al.   NATURE IMMUNOLOGY

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

(2014) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Transgenic Expression of MicroRNA-181d Augments the Stress-Sensitivity of CD4+CD8+ Thymocytes

(2014) Serkan Belkaya et al.   PLoS One

Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease

(2013) Nunzio Bottini et al.   Annual Review of Immunology

Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals

(2013) Xuguang Tai et al.   IMMUNITY

The MicroRNA miR-181 Is a Critical Cellular Metabolic Rheostat Essential for NKT Cell Ontogenesis and Lymphocyte Development and Homeostasis

(2013) Jorge Henao-Mejia et al.   IMMUNITY

MicroRNA regulation of T-cell development

(2013) James Dooley et al.   IMMUNOLOGICAL REVIEWS

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Human Neonatal Naive CD4+ T Cells Have Enhanced Activation-Dependent Signaling Regulated by the MicroRNA miR-181a

(2013) A. C. Palin et al.   JOURNAL OF IMMUNOLOGY

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis

(2013) Takashi Sekiya et al.   NATURE IMMUNOLOGY

Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

(2013) N. Zietara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection

(2013) Ivan Lilyanov Dzhagalov et al.   PLOS BIOLOGY

Dynamic MicroRNA Gene Transcription and Processing during T Cell Development

(2012) F. F. Kirigin et al.   JOURNAL OF IMMUNOLOGY

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

(2012) Inmoo Rhee et al.   NATURE IMMUNOLOGY

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Rescued Tolerant CD8 T Cells Are Preprogrammed to Reestablish the Tolerant State

(2012) A. Schietinger et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

Modulating the Strength and Threshold of NOTCH Oncogenic Signals by mir-181a-1/b-1

(2012) Rita Fragoso et al.   PLoS Genetics

T cell receptor signal strength in Tregand iNKT cell development demonstrated by a novel fluorescent reporter mouse

(2011) Amy E. Moran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

(2010) Stefan Kuchen et al.   IMMUNITY

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

Genome-wide Dissection of MicroRNA Functions and Cotargeting Networks Using Gene Set Signatures

(2010) John S. Tsang et al.   MOLECULAR CELL

Human activated CD4+ T lymphocytes increase IL-2 expression by downregulating microRNA-181c

(2010) Qian Xue et al.   MOLECULAR IMMUNOLOGY

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output

(2010) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium signaling in the development and function of T-lineage cells

(2009) Masatsugu Oh-hora   IMMUNOLOGICAL REVIEWS

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

(2009) Peter J R Ebert et al.   NATURE IMMUNOLOGY

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

T-cell Development and Function Are Modulated by Dual Specificity Phosphatase DUSP5

(2008) Panu E. Kovanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY