Calcium in the Backstage of Malaria Parasite Biology

Comparative proteomic analysis of kinesin-8B deficient Plasmodium berghei during gametogenesis

(2021) Carlos Henrique Saraiva Garcia et al.   Journal of Proteomics

Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress

(2021) Stephanie D. Nofal et al.   mBio

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

(2021) Michele S Y Tan et al.   EMBO JOURNAL

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

(2021) Aurélia C. Balestra et al.   Science Advances

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

An Endoplasmic Reticulum CREC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites

(2020) Manuel A. Fierro et al.   mBio

Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome

(2020) Karin Blomqvist et al.   mSphere

The genetic Ca2+ sensor GCaMP3 reveals multiple Ca2+ stores differentially coupled to Ca2+ entry in the human malaria parasite Plasmodium falciparum

(2020) Lucas Borges Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion

(2019) Christian Flueck et al.   PLOS BIOLOGY

Insights into physiological roles of unique metabolites released from Plasmodium-infected RBCs and their potential as clinical biomarkers for malaria

(2019) Divya Beri et al.   Scientific Reports

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

(2019) Avnish Patel et al.   PLOS BIOLOGY

CXCR4 regulates Plasmodium development in mouse and human hepatocytes

(2019) Hironori Bando et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rhoptry neck protein 11 has crucial roles during malaria parasite sporozoite invasion of salivary glands and hepatocytes

(2019) Sirasate Bantuchai et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens

(2019) Hee-Soo Park et al.   Cell Host & Microbe

High-Content Screening of the Medicines for Malaria Venture Pathogen Box for Plasmodium falciparum Digestive Vacuole-Disrupting Molecules Reveals Valuable Starting Points for Drug Discovery

(2018) Jie Xin Tong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Blocking IP 3 signal transduction pathways inhibits melatonin-induced Ca 2+ signals and impairs P. falciparum development and proliferation in erythrocytes

(2018) Mateus Fila Pecenin et al.   CELL CALCIUM

Increased Ca++ uptake by erythrocytes infected with malaria parasites: Evidence for exported proteins and novel inhibitors

(2018) Ambuj K. Kushwaha et al.   CELLULAR MICROBIOLOGY

Calcium-dependent phosphorylation ofPlasmodium falciparumserine repeat antigen 5 triggers merozoite egress

(2018) Gayatri R. Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin activate FIS1, DYN1 and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure

(2018) Pedro Scarpelli et al.   JOURNAL OF PINEAL RESEARCH

Dynamic molecular events associated to Plasmodium berghei gametogenesis through proteomic approach

(2018) Carlos H.S. Garcia et al.   Journal of Proteomics

Malaria

(2018) Elizabeth A Ashley et al.   LANCET

PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection

(2018) Abhisheka Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

(2018) Sabrina Absalon et al.   mBio

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

(2018) James A. Thomas et al.   Nature Microbiology

Calcium signaling and the lytic cycle of the Apicomplexan parasite Toxoplasma gondii

(2018) Miryam Andrea Hortua Triana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

(2018) Andrew H. Lee et al.   Scientific Reports

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

(2018) Michael J. Boucher et al.   PLOS BIOLOGY

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

(2018) Alex L Mitchell et al.   NUCLEIC ACIDS RESEARCH

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

(2018) Hanwei Fang et al.   Nature Communications

Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation

(2018) Magali Roques et al.   Biology Open

Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipids with cytoskeletal element ‘actin’ and its associated motor ‘myosin’

(2018) Vikash Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The serine/threonine phosphatases of apicomplexan parasites

(2017) Chunlin Yang et al.   MOLECULAR MICROBIOLOGY

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

(2017) Armiyaw S. Nasamu et al.   SCIENCE

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress

(2017) Paco Pino et al.   SCIENCE

Plasmodium falciparum Calcium-Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation

(2017) Abhisheka Bansal et al.   mBio

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum

(2017) Sudhir Kumar et al.   Nature Communications

Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis

(2017) Hanwei Fang et al.   eLife

Plasmodium falciparum GPCR-like receptor SR25 mediates extracellular K+ sensing coupled to Ca2+ signaling and stress survival

(2017) Miriam S. Moraes et al.   Scientific Reports

Malaria: Biology and Disease

(2016) Alan F. Cowman et al.   CELL

Acidocalcisomes of eukaryotes

(2016) Roberto Docampo et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphatases are emerging as novel druggable targets in Plasmodium

(2016) Jamal Khalife et al.   Future Microbiology

Proteomic Analysis of thePlasmodium bergheiGametocyte Egressome and Vesicular bioID of Osmiophilic Body Proteins Identifies Merozoite TRAP-like Protein (MTRAP) as an Essential Factor for Parasite Transmission

(2016) Jessica Kehrer et al.   MOLECULAR & CELLULAR PROTEOMICS

Calcium signalling in malaria parasites

(2016) Mathieu Brochet et al.   MOLECULAR MICROBIOLOGY

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G

(2016) Abhisheka Bansal et al.   mBio

Ca2+ monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor

(2016) Kishor Pandey et al.   Scientific Reports

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

(2015) Judith L. Green et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites

(2015) Ehab Mossaad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Conditional Degradation of Plasmodium Calcineurin Reveals Functions in Parasite Colonization of both Host and Vector

(2015) Nisha Philip et al.   Cell Host & Microbe

Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans

(2015) Aditya S. Paul et al.   Cell Host & Microbe

Components of the Calcium-Calcineurin Signaling Pathway in Fungal Cells and Their Potential as Antifungal Targets

(2015) Shuyuan Liu et al.   EUKARYOTIC CELL

Calcium Signaling throughout theToxoplasma gondiiLytic Cycle

(2015) Lucas Borges-Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans

(2015) Raymond Hui et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Genome wide in silico analysis of Plasmodium falciparum phosphatome

(2014) Rajan Pandey et al.   BMC GENOMICS

Calcium dynamics ofPlasmodium bergheisporozoite motility

(2014) Allison F. Carey et al.   CELLULAR MICROBIOLOGY

Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes

(2014) Rama Subba Rao Vidadala et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regulation ofPlasmodium falciparumDevelopment by Calcium-dependent Protein Kinase 7 (PfCDPK7)

(2014) Praveen Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

(2014) Thomas D. Otto et al.   Nature Communications

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

Proteomic Analysis of the Acidocalcisome, an Organelle Conserved from Bacteria to Human Cells

(2014) Guozhong Huang et al.   PLoS Pathogens

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes

(2014) Amrita Dawn et al.   PLoS Pathogens

Inhibition ofPlasmodium falciparumCDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development

(2013) Mauro F. Azevedo et al.   BIOCHEMICAL JOURNAL

Membrane transport in the malaria parasite and its host erythrocyte

(2013) Kiaran Kirk et al.   BIOCHEMICAL JOURNAL

Role of calcineurin and actin dynamics in regulated secretion of microneme proteins inPlasmodium falciparummerozoites during erythrocyte invasion

(2013) Shailja Singh et al.   CELLULAR MICROBIOLOGY

Cytoplasmic free Ca2+ is essential for multiple steps in malaria parasite egress from infected erythrocytes

(2013) Svetlana Glushakova et al.   MALARIA JOURNAL

Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling

(2013) Ajay D. Pillai et al.   MOLECULAR MICROBIOLOGY

Plasmodium berghei Calcium Dependent Protein Kinase 1 Is Not Required for Host Cell Invasion

(2013) Sylvia Jebiwott et al.   PLoS One

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum

(2013) Xiaohong Gao et al.   Nature Communications

The Plasmodium berghei Ca2+/H+ Exchanger, PbCAX, Is Essential for Tolerance to Environmental Ca2+ during Sexual Development

(2013) David S. Guttery et al.   PLoS Pathogens

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Ca2+-mediated exocytosis of subtilisin-like protease 1: a key step in egress ofPlasmodium falciparummerozoites

(2012) Shalini Agarwal et al.   CELLULAR MICROBIOLOGY

Proteolytic Activation of the Essential Parasitophorous Vacuole Cysteine Protease SERA6 Accompanies Malaria Parasite Egress from Its Host Erythrocyte

(2012) Andrea Ruecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization ofPlasmodium falciparumCalcium-dependent Protein Kinase 1 (PfCDPK1) and Its Role in Microneme Secretion during Erythrocyte Invasion

(2012) Abhisheka Bansal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling mechanisms involved in apical organelle discharge during host cell invasion by apicomplexan parasites

(2012) Shailja Singh et al.   MICROBES AND INFECTION

Investigation of the Plasmodium falciparum Food Vacuole through Inducible Expression of the Chloroquine Resistance Transporter (PfCRT)

(2012) Florian Ehlgen et al.   PLoS One

Invasion factors are coupled to key signalling events leading to the establishment of infection in apicomplexan parasites

(2011) Joana M. Santos et al.   CELLULAR MICROBIOLOGY

Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development

(2011) Yuko Doi et al.   EXPERIMENTAL PARASITOLOGY

Calcium Uptake and Proton Transport by Acidocalcisomes of Toxoplasma gondii

(2011) Peter Rohloff et al.   PLoS One

Drug-induced permeabilization of parasite's digestive vacuole is a key trigger of programmed cell death in Plasmodium falciparum

(2011) J-H Ch'Ng et al.   Cell Death & Disease

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

(2010) Rita Tewari et al.   Cell Host & Microbe

Melatonin and IP3-induced Ca2+Release from Intracellular Stores in the Malaria ParasitePlasmodium falciparumwithin Infected Red Blood Cells

(2010) Eduardo Alves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PfCHA is a mitochondrial divalent cation/H+ antiporter in Plasmodium falciparum

(2010) Alexander Rotmann et al.   MOLECULAR MICROBIOLOGY

Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes

(2010) R. Docampo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

(2009) P. A. Moura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Role of Acidocalcisomes in Parasitic Protists

(2009) SILVIA N. J. MORENO et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

The protein-phosphatome of the human malaria parasite Plasmodium falciparum

(2008) Jonathan M Wilkes et al.   BMC GENOMICS

Centrins, Cell Cycle Regulation Proteins in Human Malaria ParasitePlasmodium falciparum

(2008) Babita Mahajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Motor Complex ofPlasmodium falciparum

(2008) Judith L. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Plasmodium falciparum protein kinase 2

(2008) Kentaro Kato et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Protein Ser/Thr phosphatases of parasitic protozoa

(2008) Mikhail A. Kutuzov et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Kiss and spit: the dual roles of Toxoplasma rhoptries

(2007) John C. Boothroyd et al.   NATURE REVIEWS MICROBIOLOGY